The effects of primary cilia-mediated mechanical stimulation on nestin+-BMSCs during bone-tendon healing [0.03%]
初级纤毛介导的力学刺激对骨腱结合区巢氏干细胞的影响研究
Huabin Chen,Han Xiao,Bing Wu et al.
Huabin Chen et al.
Introduction: Mechanical stimulation has been proven to promote bone-tendon interface (BTI) healing, but the mechanism remains unclear. Objective: ...
A novel prognostic scoring system for AML patients undergoing allogeneic hematopoietic stem cell transplantation with real world validation [0.03%]
基于真实世界验证的allo-HSCT后AML患者预后评估新系统
Qing Ya Wang,Yi Fan Han,Yu Han Li et al.
Qing Ya Wang et al.
Objectives: This study aims to develop a robust predictive model for survival in AML patients undergoing allo-HSCT. Methods: It was per...
Expression reduction and a variant of a P450 gene mediate chlorpyrifos resistance in Tetranychus urticae Koch [0.03%]
拟除虫菊酯抗性基因CYP333的表达及蛋白结构变化分析
Dandan Xu,Haojie Liao,Chao He et al.
Dandan Xu et al.
Introduction: Understanding how insects and mites develop resistance to chlorpyrifos is crucial for effective field management. Although extensive research has demonstrated that T. urticae exhibits high resistance to chlo...
Developing Patient-Derived 3D-Bioprinting models of pancreatic cancer [0.03%]
基于患者的胰腺癌三维生物打印模型的开发研究论文标题翻译
Hang Sun,Yan Wang,Minghao Sun et al.
Hang Sun et al.
Introduction: Pancreatic cancer (PC) remains a challenging malignancy, and adjuvant chemotherapy is critical in improving patient survival post-surgery. However, the intrinsic heterogeneity of PC necessitates personalized...
20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters [0.03%]
20(S)原人参皂苷Rh2通过抑制LAMC2调控的ABC转运蛋白介导的耐药克服吉西他滨耐药性研究胰腺癌中的研究
Yulin Wu,Juan Zhang,Yuanyang Tian et al.
Yulin Wu et al.
Introduction: Gemcitabine (GEM) is the first-line drug for pancreatic ductal adenocarcinoma (PDAC), but drug resistance severely restricts its chemotherapeutic efficacy. Laminin subunit γ2 (LAMC2) plays a crucial role in...
Whole-body mass spectrometry imaging reveals the systemic metabolic disorder and catecholamines biosynthesis alteration on heart-gut axis in heart failure rat [0.03%]
基于心脏-肠轴的心力衰竭大鼠全身质谱成像及代谢研究
Zhengyu Fang,Qingce Zang,Jiemei Chen et al.
Zhengyu Fang et al.
Introduction: Heart failure (HF) is a systemic metabolic disorder disease, across multiorgan investigations advancing knowledge of progression and treatment of HF. Whole-body MSI provides spatiotemporal information of met...
Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF [0.03%]
纤毛动力蛋白复合物基因ITPRIP和IFT172的单倍剂量不足可导致自闭症光谱障碍及相关行为异常小鼠模型
Nanxi Zheng,Shilin Luo,Xin Zhang et al.
Nanxi Zheng et al.
Introduction: Primary cilia are hair-like solitary organelles growing on most mammalian cells that play fundamental roles in embryonic patterning and organogenesis. Defective cilia often cause a suite of inherited disease...
Biomarkers differentiating regression from progression among untreated cervical intraepithelial neoplasia grade 2 lesions [0.03%]
未治疗的宫颈上皮内瘤变Ⅱ级病灶转归与进展的鉴别标志物研究
Xiang Li,Yan Chen,Jing Xiong et al.
Xiang Li et al.
Background: Cervical intraepithelial neoplasia grade 2 (CIN2) is one of the precursor stages before cervical lesions develop into cervical cancer. The spontaneous development of CIN2 is ambiguous. One part of CIN2 lesions...
tsRNA modifications: An emerging layer of biological regulation in disease [0.03%]
疾病中的tsRNA修饰：新兴的生物学调控层
Yaomin Liang,Ding Ji,Xiaoling Ying et al.
Yaomin Liang et al.
Background: Transfer RNA (tRNA)-derived small RNA (tsRNA) represents an important and increasingly valued type of small non-coding RNA (sncRNA). The investigation of tRNA and tsRNA modification crosswalks has not only pro...
Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies [0.03%]
基于理性的BCR-ABL激酶抑制剂设计用于改善白血病治疗的共价和前药/双药策略
Jie Sun,Liang Lou,Chengjun Zhu et al.
Jie Sun et al.
Background: Chronic Myeloid Leukemia (CML) is a blood cancer that remains challenging to cure due to drug resistance and side effects from current BCR-ABL inhibitors. There is an urgent need for novel and more effective B...