Palmitoylated COX-2Cys555 reprogramed mitochondrial metabolism in pyroptotic inflammatory injury in patients with post-acute COVID-19 syndrome [0.03%]
棕榈酰化的COX-2Cys555在急性后COVID-19综合征患者pyroptosis炎症损伤中的线粒体代谢重编程作用
Jia-Shen Wu,Chi-Yu Xu,Su-Min Mo et al.
Jia-Shen Wu et al.
Introduction: The complex interplay between protein palmitoylation, mitochondrial dynamics, and inflammatory responses plays a pivotal role in respiratory diseases. One significant features of post-acute coronavirus disea...
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis [0.03%]
PI3K/AKT/mTOR信号轴调控线粒体自噬和焦亡：椎间盘退变治疗靶点PTPN22的研究
Haibo Liang,Shu Yang,Yeheng Huang et al.
Haibo Liang et al.
Introduction: Intervertebral disc degeneration (IDD) is a predominant risk factor for low back pain (LBP). However, the mechanisms underlying IDD progression remain unclear. ...
Epigallocatechin gallate prevents and alleviates type 2 diabetes mellitus (T2DM) through gut microbiota and multi-organ interactions in Wistar healthy rats and GK T2DM rats [0.03%]
表没食子儿茶素没食子酸酯通过肠道菌群及多器官互作预防和缓解Wistar健康大鼠和GK2型糖尿病模型大鼠糖尿病 mellitus(T2DM)
Hongzhe Zeng,Changwei Liu,Liwei Wan et al.
Hongzhe Zeng et al.
Introduction: As the main active ingredient of the first FDA-approved phytochemical drug, epigallocatechin gallate (EGCG) can effectively alleviate glucolipid metabolic disorders. However, existing studies mainly focuses ...
Dynamic profiling of BMSC-dECM reveals accumulation of core matrisome proteins suppresses osteogenic differentiation and bone regeneration [0.03%]
动态分析BMSC-dECM揭示核心基质蛋白的积累抑制成骨分化和骨再生
Mei Li,Weilai Zhu,Mingyu Hu et al.
Mei Li et al.
Introduction: The extracellular matrix (ECM) of bone mesenchymal stem cells (BMSCs) plays a critical role in tissue development and regeneration. Rather than being inert, the ECM exhibits a dynamic structure that determin...
New insight into the role of SOCS family in immune regulation and autoimmune pathogenesis [0.03%]
细胞抑制素家族在免疫调节和自身免疫疾病中的作用机制的新见解
Shiyi Liu,Mingwei Wang,Liangjie Xu et al.
Shiyi Liu et al.
Background: Suppressor of cytokine signaling (SOCS) proteins regulate signal transduction by interacting with cytokine receptors and signaling proteins and targeting associated proteins for degradation. Recent studies hav...
Dynamic regulation and targeted interventions of macrophages in ischemia-reperfusion injury [0.03%]
缺血再灌注损伤中巨噬细胞的动态调控与靶向干预措施研究进展
Ping Lu,Ruotong Shen,Jingjing Yang et al.
Ping Lu et al.
Background: Ischemia-Reperfusion Injury (IRI) is a complex pathophysiological process characterized by oxidative stress and inflammatory responses during tissue reperfusion, leading to severe organ dysfunction. Macrophage...
TaPP2C-a5 fine-tunes wheat seed dormancy and germination with a Triticeae-specific, alternatively spliced transcript [0.03%]
TaPP2C-a5通过一个Triticeae特异的可选择性拼接转录本调节小麦种子休眠和萌发
Qian Zhang,Xiaofen Yu,Ya&#x;nan Wu et al.
Qian Zhang et al.
Introduction: The sessile plants often experience environmental conditions not ideal for growth, and therefore have evolved strategies to survive and adapt to stress conditions. Abscisic acid (ABA) regulates plant develop...
Basic mechanism of mobilizing cell movement during invasion of glioblastoma and target selection of targeted therapy [0.03%]
胶质母细胞瘤侵袭过程中动员细胞运动的基本机制及靶向治疗的靶点选择
Jie Xu,Pengfei Shi,Liqun Yang et al.
Jie Xu et al.
Background: Glioblastoma (GBM), also known as glioblastoma multiforme, is a rapidly growing and highly invasive malignant tumor. Due to the inability to clearly distinguish between glioblastoma and normal tissue, surgery ...
SA supplementation during lactation promotes learning and memory by reducing H3K27me3 levels [0.03%]
泌乳期沙棘叶提取物补充通过降低H3K27me3水平促进学习和记忆能力
Chengqing Huang,Shu Ai,Mengmeng Wang et al.
Chengqing Huang et al.
Introduction: Sialic acid (SA) is an essential nutrient for brain development and cognition. Infants lack the capacity to synthesize sufficient SA independently, requiring reliance on maternal or exogenous sources. For ea...
Heterologous expression of the barley-specific HvbZIP87 transcription factor in wheat enhances broad-spectrum disease resistance with balanced yield [0.03%]
barley特异的HvbZIP87转录因子在小麦中的异源表达可提高广谱抗病性并保持稳产水平
Shuqing Zhao,Ning Wang,Mengyu Li et al.
Shuqing Zhao et al.
Introduction: NPR1, a protein that interacts with bZIP transcription factors known as TGAs, plays a pivotal role in coordinating systemic acquired resistance (SAR) in plants. Nevertheless, the molecular intricacies govern...