Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer [0.03%]
血红素氧合酶1（HO-1）是逆转非小细胞肺癌顺铂耐药的药物靶点
Jie Mei,Hui-Xiang Tian,Xiao-Ye Zhang et al.
Jie Mei et al.
Introduction: Platinum-based drugs, the most widely used chemotherapeutic drugs in clinical oncology, have long faced the problem of drug resistance, which is urgently in need of resolution. Identifying biomarkers of drug...
Beyond the Brain: Exploring the multi-organ axes in Parkinson's disease pathogenesis [0.03%]
超越大脑：探索帕金森病发病机制中的多器官轴
Tingting Liu,Haojie Wu,Jianshe Wei
Tingting Liu
Background: Parkinson's Disease (PD), a complex neurodegenerative disorder, is increasingly recognized as a systemic condition involving multi-organ interactions. Emerging evidence highlights roles of organ-brain axes (lu...
Novel function of macrophage migration inhibitory factor in regulating post-infarct inflammation and the therapeutic significance [0.03%]
巨噬细胞迁移抑制因子调控心梗后炎症的新型功能及其治疗学意义
Ling Zhao,Guo-Li Du,Amanguli Ruze et al.
Ling Zhao et al.
Introduction: Recent studies indicate that macrophage migration inhibitory factor (MIF) has a dual role in myocardial infarction (MI), with different cellular sources of MIF influencing inflammation and healing differenti...
Trends, patterns, and risk factors of esophageal cancer mortality in China, 2008-2021: A national mortality Surveillance System data analysis [0.03%]
中国食管癌死亡率的流行趋势、模式和危险因素（2008—2021年）：全国死因监测系统数据的分析研究
Yunfei Jiao,Tinglu Wang,Lin Fu et al.
Yunfei Jiao et al.
Introduction: According to the International Agency for Research on Cancer, China had the highest mortality burden of esophageal cancer (EC) globally in 2022. ...
Association between dietary amino acid intake and the risk of metabolic dysfunction-associated steatotic liver disease [0.03%]
膳食氨基酸摄入与代谢功能紊乱相关脂肪肝病风险的关系研究
Ruoqi Zhou,Xinrong Zhang,Xinxin Liu et al.
Ruoqi Zhou et al.
Introduction: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is becoming the major chronic liver disease, and diet plays crucial role in MASLD prevention. ...
Fe-S cluster deficiency drives small colony variant formation in persistent infections [0.03%]
缺铁诱导的硫铁簇缺陷驱动了持续性感染中的小菌落变异体的形成
Tianchi Chen,Zhiyi Ye,Weiyi Huang et al.
Tianchi Chen et al.
Introduction: Small colony variants (SCVs) of Staphylococcus aureus (S. aureus) are associated with persistent infections and poor clinical outcomes. The mechanisms driving stable SCV formation remain poorly understood, p...
Overexpression of soybean flavonoid 3'-hydroxylase enhances plant salt tolerance by promoting ascorbic acid biosynthesis [0.03%]
大豆黄酮3′-羟基酶的过表达通过促进抗坏血酸生物合成来增强植物耐盐性
Jianfei Wu,Xiaokun Wang,Jiawei Xu et al.
Jianfei Wu et al.
Introduction: Salt stress is a major cause of crop loss. Soybean (Glycine max), a globally vital legume crop, faces mounting yield constraints due to soil salinization. It is known that the flavonoid biosynthesis pathway ...
Mechanical mechanics-reclaiming a new battlefield for chronic liver disease [0.03%]
力学力学——为慢性肝病重新争取新的战场
Yiheng Zhang,Tianle Ma,XingXing Lu et al.
Yiheng Zhang et al.
Background: In the 21st century, significant breakthroughs have been made in the research of chronic liver disease. New biochemical markers of pathogenicity and corresponding drugs continue to emerge. However, current tre...
Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis [0.03%]
通过抑制TNF/CELSR2/p65/Kla-HDAC1/EPAS1轴靶向间充质单核细胞衍生的巨噬细胞以增强胶质母细胞瘤对替莫唑胺的敏感性
Wei Gao,Xinmiao Long,Xiang Lin et al.
Wei Gao et al.
Introduction: Temozolomide (TMZ) resistance poses a significant challenge to the treatment of aggressive and highly lethal glioblastomas (GBM). Monocyte-derived Macrophages (MDM) within the tumor microenvironment are key ...
Anthocyanin accumulation differences in European pears caused by Phytochrome-interacting factor 3 (PcPIF3) promoter mutations under UV-B [0.03%]
紫外辐射B介导的PcPIF3启动子突变引起欧洲梨花青素积累差异性增强响应机制研究
Haowei Cao,Yingying Qu,Lei Guo et al.
Haowei Cao et al.
The phenomenon of red fading in late-stage red-skinned pear fruit development significantly impacts its value. This phenomenon also occurs in 'Starkrimson', albeit to a lesser extent compared to 'Red Bartlett' and other varieties. The reaso...