Effect of mitochondrial translocator protein TSPO on LPS-induced cardiac dysfunction [0.03%]
外周TSPO调节脂多糖诱导的心肌损伤中的线粒体自噬与心功能障碍
Xingyue Li,Xiao Chen,Feng-Yuan Yang et al.
Xingyue Li et al.
Introduction: Sepsis-induced cardiac dysfunction is one of the most serious complications of sepsis. The mitochondrial translocator protein (TSPO), a mitochondrial outer membrane protein, is widely used as a diagnostic ma...
Activity-based protein profiling guided new target identification of quinazoline derivatives for expediting bactericide discovery: Activity-based protein profiling derived new target discovery of antibacterial quinazolines [0.03%]
基于活性的蛋白质谱学引导喹唑啉衍生物新靶点鉴定以促进杀菌剂发现：基于活性的蛋白质谱学衍生的新靶点发现抗生素喹唑啉
Jiao Meng,Ling Zhang,Xinxin Tuo et al.
Jiao Meng et al.
Introduction: The looming antibiotic-resistance problem has imposed an enormous crisis on global public health and agricultural development. Even worse, the evolution and widespread distribution of antibiotic-resistance e...
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia [0.03%]
由落悠悠素诱导的整合应激反应激活可缓解急性髓系白血病中ABT-199耐药性
Dijiong Wu,Man Li,Yaonan Hong et al.
Dijiong Wu et al.
Introduction: ABT-199 (venetoclax) is a BCL-2 suppressor with pronounced effects on acute myeloid leukemia (AML). However, its usefulness as a monotherapy or in combination with hypomethylating medicines like azacitidine ...
Elevated muramyl dipeptide by sialic acid-facilitated postantibiotic pathobiont expansion contributes to gut dysbiosis-induced mastitis in mice [0.03%]
唾液酸促进的抗生素治疗后肠道条件致病菌的增殖导致鸟苷二肽诱导的小鼠乳腺炎
Min Qiu,Cong Ye,Lijuan Bao et al.
Min Qiu et al.
Introduction: In responses to antibiotics exposure, gut dysbiosis is a risk factor not only for pathogen infection but also for facilitating pathobiont expansion, resulting in increased inflammatory responses in the gut a...
Hippocampal dipeptidyl peptidase 9 bidirectionally regulates memory associated with synaptic plasticity [0.03%]
海马二肽基肽酶9通过双向调节与突触可塑性相关的记忆功能
Ya-Bo Zhao,Shi-Zhe Wang,Wen-Ting Guo et al.
Ya-Bo Zhao et al.
Introduction: Subtypes of the dipeptidyl peptidase (DPP) family, such as DPP4, are reportedly associated with memory impairment. DPP9 is widely distributed in cells throughout the body, including the brain. However, wheth...
Columbianadin ameliorates rheumatoid arthritis by attenuating synoviocyte hyperplasia through targeted vimentin to inhibit the VAV2/Rac-1 signaling pathway [0.03%]
宗气通络颗粒通过靶向中间丝蛋白缓解滑膜成纤维细胞增生抑制VAS升高信号通路治疗类风湿性关节炎
Yuli Han,Changqing Liu,Shujing Chen et al.
Yuli Han et al.
Introduction: Rheumatoid arthritis (RA) is an autoimmune disease pathologically characterized by synovial inflammation. The abnormal activation of synoviocytes seems to accompany the progression of RA. The role and exact ...
Serum metabolite biomarkers for the early diagnosis and monitoring of age-related macular degeneration [0.03%]
用于年龄相关性黄斑变性的早期诊断和监测的血清代谢标志物
Shengjie Li,Yichao Qiu,Yingzhu Li et al.
Shengjie Li et al.
Introduction: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness worldwide, with significant challenges for early diagnosis and treatment. ...
Zhouhui Yao,Yandan Lu,Pingping Wang et al.
Zhouhui Yao et al.
Background: Fibrosis is a tissue damage repair response caused by multiple pathogenic factors which could occur in almost every apparatus and leading to the tissue structure damage, physiological abnormality, and even org...
Unravelling the role of WRKY transcription factors in leaf senescence: Genetic and molecular insights [0.03%]
WRKY转录因子在叶片衰老中的作用机制：遗传和分子见解
Zishan Ahmad,Muthusamy Ramakrishnan,Chunyue Wang et al.
Zishan Ahmad et al.
Background: Leaf senescence (LS), the final phase in leaf development, is an important and precisely regulated process crucial for plant well-being and the redistribution of nutrients. It is intricately controlled by vari...
Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia-reperfusion injury [0.03%]
淫羊藿素C通过上调巨噬细胞源琥珀酸促进心肌缺血再灌注损伤修复
Sixuan Chen,Haojie Yao,Yanmei Lou et al.
Sixuan Chen et al.
Introduction: Myocardial ischemia-reperfusion injury (MIRI) remains a prevalent clinical challenge globally, lacking an ideal therapeutic strategy. Macrophages play a pivotal role in MIRI pathophysiology, exhibiting dynam...