Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research [0.03%]
一种用于加速转化研究的全人胶质母细胞瘤脑类器官模型的发展
Sandra Horschitz,Ammar Jabali,Sophie Heuer et al.
Sandra Horschitz et al.
Introduction: Glioblastoma (GBM) progression and therapeutic resistance are significantly influenced by complex interactions between tumor cells and the brain microenvironment, particularly neurons. However, studying thes...
Screening, identification and detection of the regulated and emerging mycotoxins in edible and medicinal products by integrating diversiform liquid chromatography/mass spectrometry systems and high-throughput sequencing of contaminated fungi [0.03%]
整合多种形式液相色谱/质谱系统和高通量测序真菌技术对食药产品中受控和新出现的霉毒素进行筛选、识别及检测
Xiao-Yan Xu,Yu Wang,Lian-Xing Wang et al.
Xiao-Yan Xu et al.
Introduction: Safety issues pertaining to mycotoxin contamination of the edible and medicinal products (EMPs) have attracted significant attention. EMPs not only have high nutritional values, but also exert valuable medic...
Senkyunolide A interrupts TRAF6-HDAC3 interaction to epigenetically suppress c-MYC and attenuate cholestatic liver injury [0.03%]
senkyunolide A干扰TRAF6-HDAC3相互作用以表观遗传抑制c-MYC和减轻胆汁淤积性肝损伤
Yajing Li,Runping Liu,Jianan Li et al.
Yajing Li et al.
Introduction Cholestatic liver diseases are highly prevalent and lack effective treatment, ultimately progressing to end-stage liver diseases. Our recent study indicates that the interplay between c-MYC and lncRNA H19 exacerbates the ductul...
Natural, safety immunomodulatory derivatives of lactobacillus biofilms promote diabetic wound healing by metabolically regulating macrophage phenotype and alleviating local inflammation [0.03%]
天然乳酸菌生物膜免疫调节衍生代谢物通过调节巨噬细胞表型和缓解局部炎症促进糖尿病伤口愈合
Qingwei Zhou,Junjie Chi,Jintao Yang et al.
Qingwei Zhou et al.
Introduction: Long-term inflammatory microenvironment further impairs the healing process of diabetic wounds. Many studies have shown that Lactobacillus can regulate immune function and promote injured tissue repair. Howe...
Development and validation of a deep learning model based on cascade mask regional convolutional neural network to noninvasively and accurately identify human round spermatids [0.03%]
基于级联掩码区域卷积神经网络的深度学习模型的发展和验证，以非侵入性且准确地识别人类圆形精子细胞
Yujiao Sun,Shihao Shao,Jiangwei Huang et al.
Yujiao Sun et al.
Introduction: The difficulty of identifying human round spermatids (hRSs) has impeded applications of the human round spermatid injection (ROSI) technique. RSs can be accurately screened through flow cytometric analysis u...
Lipidomic signatures as predictive biomarkers for early-onset lung cancer: Identification and development of a risk prediction model [0.03%]
脂质组标志物作为早期肺癌预测生物标志物的识别及风险预测模型的建立
Fei Wang,Zeming Guo,Wei Tang et al.
Fei Wang et al.
Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. While traditionally associated with older adults, early-onset lung cancer (EOLC) is rising, particularly in Asia, which accounts for 75...
Comprehensive insights into emerging advances in the Neurobiology of anorexia [0.03%]
厌食症神经生物学新进展的全面见解
Liwei Mao,Lian Wang,Zhihai Huang et al.
Liwei Mao et al.
Anorexia is a complex eating disorder influenced by genetic, environmental, psychological, and socio-cultural factors. Research into its molecular mechanisms and neural circuits has deepened our understanding of its pathogenesis. Recent adv...
Multifunctional nanoplatform for tumor chemodynamic and self-amplified photodynamic cascade therapy [0.03%]
用于肿瘤化疗动力学和自放大光动力级联治疗的多功能纳米平台
Xingyu Luo,Haifeng Qi,Manqi Yan et al.
Xingyu Luo et al.
Introduction: 5-Aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) has demonstrated considerable potential in breast cancer treatment. However, its efficacy is limited by low tissue selectivity and the rapid con...
Thousands-years-old deep-sea DNA viruses reveal the evolution of human pathogenic viruses [0.03%]
千年前的深海DNA病毒揭示了人类病原病毒的进化路径
Tianliang He,Xinyi Zhang,Xiaobo Zhang
Tianliang He
Introduction: In the last two decades, outbreaks of pathogenic viruses have led to significant human mortality and economic repercussions. Despite extensive investigations into tracing these viruses in terrestrial environ...
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production [0.03%]
二甲双胍通过减少乙酰辅酶A的生成来阻断STAT3乙酰化从而缓解结肠炎
Xiangyun Li,Zixuan Xiang,Xiaoli Wang et al.
Xiangyun Li et al.
Background and aims: While metformin has been shown to alleviate dextran sulfate sodium (DSS)-induced colitis in murine models, the mechanisms underlying its anti-inflammatory and barrier-restorative effects remain poorly...