Advanced machine learning schemes for prediction CO2 flux based experimental approach in underground coal fire areas [0.03%]
基于实验方法预测地下煤火区二氧化碳通量的先进机器学习方案
Yongjun Wang,Mingze Guo,Hung Vo Thanh et al.
Yongjun Wang et al.
Introduction: Underground coal fires pose significant environmental and health risks due to releasing CO2 emissions. Predicting surface CO2 flux accurately in underground coal fire areas is crucial for understanding the d...
Akt-FoxO signaling drives co-adaptation to insecticide and host plant stresses in an herbivorous insect [0.03%]
Akt-FoxO信号驱动食植害虫适应杀虫剂和寄主植物胁迫的协同进化
Huihui Zhang,Haoli Gao,Xumin Lin et al.
Huihui Zhang et al.
Introduction: Ongoing interactions between host and herbivorous insect trigger a co-evolutionary arms race. Genetic diversity within insects facilitates their adaptation to phytochemicals and their derivatives, including ...
Pan-genome analysis reveals genomic variations during enoki mushroom domestication, with emphasis on genetic signatures of cap color and stipe length [0.03%]
全基因组分析揭示了金针菇驯化过程中的基因组变异，并重点强调了菌盖颜色和菌柄长度的遗传标志
Fei Liu,Xin-Bin Ma,Bei Han et al.
Fei Liu et al.
Introduction: The domestication of edible mushrooms, including Flammulina filiformis, offers valuable insights into the genetic changes driven by artificial selection. Understanding these changes is crucial for uncovering...
Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer [0.03%]
四氢姜黄素靶向TRIP13介导三阴性乳腺癌细胞c-FLIP泛素化降解的作用及机制研究
Yu-Jie Sun,Qiang Zhang,Shi-Jie Cao et al.
Yu-Jie Sun et al.
Introduction: Triple-negative breast cancer (TNBC) has a high mortality rate and limited treatment options. Tetrahydrocurcumin (THC), a major metabolite of curcumin, has potential antitumor activities. However, the antitu...
Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway [0.03%]
山柰酚通过HDAC3介导的Nrf2信号通路减少氧化应激从而缓解心肌缺血损伤
Zejun Yue,Yirong Zhang,Wei Zhang et al.
Zejun Yue et al.
Introduction: Kaempferol (KAE) is a flavonoid found in various plants. Recent studies showed that high dietary intake of KAE was associated with a lower risk of myocardial infarction; however, the cardioprotective mechani...
A molecular perspective on the role of FERONIA in root growth, nutrient uptake, stress sensing and microbiome assembly [0.03%]
FERONIA在根系生长、养分吸收、胁迫感知及微生物群组装作用的分子机制研究进展
Sajad Ali,Anshika Tyagi,Suvin Park et al.
Sajad Ali et al.
Background: Roots perform multifaceted functions in plants such as movement of nutrients and water, sensing stressors, shaping microbiome, and providing structural support. How roots perceive and respond above traits at t...
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway [0.03%]
TRPM2介导的前馈回路通过钙-cGAS-STING-NF-κB通路促进骨关节炎软骨细胞损伤
Kai Sun,Xiong Zhang,Liangcai Hou et al.
Kai Sun et al.
Introductions: Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited. The transient receptor potential melastatin 2 (TRPM2) is involved ...
Xuan Tang,Fengjin Zhou,Sicheng Wang et al.
Xuan Tang et al.
The effective regeneration of bone/cartilage defects remains a significant clinical challenge, causing irreversible damage to millions annually.Conventional therapies such as autologous or artificial bone grafting often yield unsatisfactory...
Trichosanthin elicits antitumor activity via MICU3 mediated mitochondria calcium influx [0.03%]
穿心莲内酯诱导的抗肿瘤活性通过MICU3介导的线粒体钙离子流入实现
Yunbin Zhang,Xuping Ding,Qian Zhang et al.
Yunbin Zhang et al.
Introduction: Trichosanthin (TK) is a glycoprotein extracted from the Chinese medicinal herb Trichosanthes kirilowi, which has anti-virus and anti-tumor activity. However, the target and detailed mechanism of TK remains e...
Meiyu Huang,Keshan Wang,Anshu Li et al.
Meiyu Huang et al.
Introduction: The RNA-guided nuclease Cas9 can be used as a programmable transcription activator, but there is still room for improvement in its effectiveness in eukaryotes, and its potential in cancer genetic therapy has...