Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy [0.03%]
Astragaloside IV通过DUSP1-Prohibitin 2介导的线粒体质量控制和内质网-自噬缓解脓毒症心肌损伤
Junyan Wang,Xiangyi Pu,Haowen Zhuang et al.
Junyan Wang et al.
Introduction: Septic cardiomyopathy (SCM) is a complication of myocardial injury in patients with severe sepsis. Objectives: This study...
Oncogenic cholesterol rewires lipid metabolism in hepatocellular carcinoma via the CSNK2A1-IGF2R Ser2484 axis [0.03%]
致癌胆固醇通过CSNK2A1-IGF2R Ser2484轴重新编程肝细胞癌脂质代谢路径
Ren-Yi Su,Chen-Hao Xu,Hai-Jun Guo et al.
Ren-Yi Su et al.
Introduction: Alcohol consumption and hepatitis B virus (HBV) infection are common risk factors for hepatocellular carcinoma (HCC). However, few studies have focused on elucidating the mechanisms of HCC with combined alco...
Deficiency of myeloid NPC1 exacerbates liver injury and fibrosis by impairing macrophage efferocytosis [0.03%]
髓系NPC1缺乏通过损害巨噬细胞的胞葬作用加剧肝损伤和纤维化
Dongwei Guan,Pengju Huang,Xinlei Liu et al.
Dongwei Guan et al.
Introduction: Niemann-Pick C1 (NPC1), a lysosomal cholesterol transport protein, is required for efficient efferocytosis. Patients with Npc1 mutation are frequently accompanied with hepatic symptoms, including hepatomegal...
Transformative applications of oculomics-based AI approaches in the management of systemic diseases: A systematic review [0.03%]
基于眼基因组学的AI在全身性疾病管理中的变革性应用：系统综述
Zhongwen Li,Shiqi Yin,Shihong Wang et al.
Zhongwen Li et al.
Background: Systemic diseases, such as cardiovascular and cerebrovascular conditions, pose significant global health challenges due to their high mortality rates. Early identification and intervention in systemic diseases...
Host genetic regulation of specific functional groups in the rumen microbiome of dairy cows: Implications for lactation trait [0.03%]
宿主基因调控对乳牛瘤胃微生物组中特定功能群的影响及其对泌乳性状的意义
Hao Bai,Zheng Lai,Jiawei Zhang et al.
Hao Bai et al.
Introduction: Ruminants play a pivotal role in our society by transforming non-consumable substances from industrial by-products and plant fibers into valuable resources such as meat and milk. This remarkable conversion a...
Biological functions and pharmacological behaviors of bile acids in metabolic diseases [0.03%]
胆汁酸在代谢性疾病中的生物学功能和药理学行为
Tongxi Zhuang,Xunjiang Wang,Zixuan Wang et al.
Tongxi Zhuang et al.
Background: Bile acids, synthesized endogenously from cholesterol, play a central role in metabolic regulation within the enterohepatic circulatory system. Traditionally known as emulsifying agents that facilitate the int...
Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges [0.03%]
人体健康和疾病中的乳酸介导的乳酸化修饰：进展与挑战
Xue-Ting Hu,Xiao-Feng Wu,Jin-Yi Xu et al.
Xue-Ting Hu et al.
Background: Lactate was once considered as metabolic waste for a long time. In 2019, Professor Zhao Yingming's team from the University of Chicago found that lactate could also be used as a substrate to induce histone lac...
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms [0.03%]
脑靶向自身免疫与长新冠及其慢性疲劳综合症和情感症状密切相关
Abbas F Almulla,Michael Maes,Bo Zhou et al.
Abbas F Almulla et al.
Introduction: Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ...
Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3/ARF4 signaling in thrombin-mediated intracerebral hemorrhage [0.03%]
血栓素介导的脑出血中内皮NMMHC IIA从PAR1解离激活CREB3 / ARF4信号通路
Yujie Dai,Liangying Bao,Juan Huang et al.
Yujie Dai et al.
Introduction: There is an urgent need for cerebroprotective interventions to improve the suboptimal outcomes with intracerebral hemorrhage (ICH). Despite the important role of nonmuscle myosin heavy chain IIA (NMMHC IIA) ...
Increased Rab1a accelerates osteoarthritis by inhibiting autophagy via activation of the mTORC1-S6K pathway [0.03%]
Rab1a通过激活mTORC1-S6K通路抑制自噬从而加速骨关节炎的发展
Ze Chen,Mingze Tang,Zewei Wu et al.
Ze Chen et al.
Introduction: Cartilage degradation is a critical alteration in the progression of osteoarthritis (OA) due to the disorder of chondrocyte metabolic homeostasis. Autophagy plays an important role in maintaining intracellul...