Resibufogenin protects against atherosclerosis in ApoE-/- mice through blocking NLRP3 inflammasome assembly [0.03%]
树脂苷素通过阻断NLRP3炎性小体组装保护动脉粥样硬化Apoe基因敲除小鼠模型
Chen Xiaoyang,Chen Yijun,Zhai Chenguang et al.
Chen Xiaoyang et al.
Introduction: Atherosclerosis (AS), a major cause of cardiovascular diseases, is characterized by lipid accumulation and chronic inflammation within arterial walls. Traditional treatments, such as statins, are often ineff...
Urate-lowering effect of delphinidin-3-glucoside in red kidney beans via binding to the FAD site of the XO enzyme [0.03%]
飞燕草素-3-葡萄糖苷通过与黄嘌呤氧化酶的FAD结合位点结合抑制尿酸生成作用机制研究
Yanling Chen,Yingtong Jiang,Lei Huang et al.
Yanling Chen et al.
Background: The incidence of hyperuricemia (HUA) is increasing globally, posing serious health risks. The discovery of natural urate-lowering agents is urgently needed. ...
Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer's disease [0.03%]
杜仲叶多糖通过重塑肠道菌群改善阿尔茨海默病学习记忆障碍的作用及机制研究
Yongkang Zhao,Wenxing Zhao,Xuejun Chai et al.
Yongkang Zhao et al.
Background: Alzheimer's disease (AD), which is a chronic neurodegenerative disorder, is marked by the progressive deteriorations in learning and memory capabilities. The microbiota-gut-brain axis has come to be regarded a...
Design, synthesis and activity evaluation of dual-target inhibitors against papain-like and main proteases of porcine epidemic diarrhea virus [0.03%]
猪流行性腹泻病毒半胱氨酸蛋白酶和主要蛋白酶双靶点抑制剂的设计、合成及活性评价
Jiashu Chen,Yuxi Lin,Chenxia Gao et al.
Jiashu Chen et al.
Introduction: Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), threatens the global pig industry due to lack of drugs. PEDV replication relies on PLpro and Mpro, which are crucial targets...
Medical gas plasma modifies Nrf2 signaling in diabetic wound healing [0.03%]
医学等离子体对糖尿病伤口愈合中Nrf2信号传导的调节作用
Anke Schmidt,Lea Miebach,Can Bagli et al.
Anke Schmidt et al.
Introduction: Diabetes mellitus is a chronic disease that can disrupt physiologic wound healing. Medical gas plasma technology produces therapeutic reactive species that support wound healing. ...
Pulsed electromagnetic fields treatment ameliorates cardiac function after myocardial infarction in mice and pigs [0.03%]
脉冲电磁场治疗可改善小鼠和猪心肌梗死后的心脏功能
Shiqi Wang,Gaiqin Pei,Jiayu Shen et al.
Shiqi Wang et al.
Introduction: Ischemic heart disease (IHD) is a prominent contributor to mortality worldwide, with myocardial infarction (MI) representing its most severe manifestation. Pulsed electromagnetic fields (PEMF) treatment show...
Gastrodin enhances stress resilience through promoting Wnt/β-Catenin-Dependent neurogenesis [0.03%]
gastrodin通过促进Wnt/β-catenin依赖性神经发生来增强压力耐受性
Haili Zhang,Zhihuang Zhao,Pei Liu et al.
Haili Zhang et al.
Background: Enhancing stress resilience constitutes a pivotal strategy in mitigating the risk of depression, making it a critical component of both prevention and treatment. In the current work, we identified a compound, ...
Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial networks via tryptophan metabolism and AHR-Nrf2 signaling [0.03%]
通过色氨酸代谢和AHR-Nrf2信号调节肠道微生物网络，芽孢杆菌thetaiotaomicron成为腹泻的共生盟友
Yuheng Luo,Cong Lan,Wen Ren et al.
Yuheng Luo et al.
Introduction: Bacteroides is a crucial mucosal symbiotic bacterium in mammals, with Bacteroides thetaiotaomicron (B. thetaiotaomicron) being particularly noteworthy as a glyco-specialist due to its significant nutritional...
Comparative single-cell transcriptomic map reveals divergence in leaves between two cotton species at cell type resolution [0.03%]
单细胞转录组图谱揭示了两种棉种叶片细胞类型的差异性
Hailiang Cheng,Shang Liu,Youping Zhang et al.
Hailiang Cheng et al.
Introduction: Leaves are important functional organs in plants that determine yield and quality of crop. Upland cotton and sea-island cotton contribute more than 90% of the cotton fiber production annually. Deciphering an...
MRI-based radiomics to determine the role of thigh muscle quality in the development of knee osteoarthritis: A discovery and validation study [0.03%]
基于MRI的影像组学确定股四头肌质量在膝骨关节炎发病中的作用：一项发现与验证研究
Qin Dang,Zixuan Hong,Dong Zeng et al.
Qin Dang et al.
Introduction: Although the reduced muscle quality is common in elderly people, its role in the development of knee osteoarthritis (OA) remains unclear. Magnetic Resonance Imaging (MRI) is considered the gold standard imag...