Hypo-osmolarity promotes naive pluripotency by reshaping cytoskeleton and increasing chromatin accessibility [0.03%]
低渗透压通过重塑细胞骨架和增加染色质可及性促进naive多能性
Renhong Lu,Bowen Lin,Zheyi Lin et al.
Renhong Lu et al.
Introduction: Cell fate determination and transition are of paramount importance in biology and medicine. Naive pluripotency could be achieved by reprogramming differentiated cells. However, the mechanism is less clear. O...
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy [0.03%]
通过Hyperforin靶向Dlat-Trpv3通路以非经典途径促进脂肪产热作为一种有效的抗肥胖策略
Sijia Lu,Quanxin Jiang,Peihui Zhou et al.
Sijia Lu et al.
Introduction: Promoting adipose thermogenesis is considered as a promising therapeutic intervention in obesity. However, endeavors to develop anti-obesity medications by targeting the canonical thermogenesis regulatory pa...
The potential of circular RNAs as biomarkers and therapeutic targets for gastric cancer: A comprehensive review [0.03%]
循环RNA作为胃癌生物标志物和治疗靶点的潜力：全面综述
Junlin Pu,Xiuli Yan,Hui Zhang
Junlin Pu
Background: Gastric cancer (GC) is a global health concern, contributing significantly to cancer-related mortality rates. Early detection is vital for improving patient outcomes. Recently, circular RNAs (circRNAs) have em...
Full dimensional dynamic 3D convolution and point cloud in pulmonary nodule detection [0.03%]
全维度动态卷积及点云在肺结节检测中的应用研究
Yun Tie,Ying Wang,Dalong Zhang et al.
Yun Tie et al.
Lung cancer is a leading cause of death worldwide, making early and accurate diagnosis essential for improving patient outcomes. Recently, deep learning (DL) has proven to be a powerful tool, significantly enhancing the accuracy of computer...
Exercise-regulated lipolysis: Its role and mechanism in health and diseases [0.03%]
运动调节的脂肪分解作用：其在健康和疾病中的作用和机制
Jie-Ying Zhu,Liang Guo
Jie-Ying Zhu
Exercise has received considerable attention because of its importance not just in regulating physiological function, but also in ameliorating multiple pathological processes. Among these processes, lipolysis may play an important role in e...
Manipulation of artificial light environment improves plant biomass and fruit nutritional quality in tomato [0.03%]
调控人工光环境可以提高番茄的生物量和果实营养品质
Ying Zhang,Kangyou Zhu,Xiujie Wang et al.
Ying Zhang et al.
Introduction: The yield and quality of tomato (Solanum lycopersicum. L) are often decreased when plants suffer from low light intensity and short-photoperiod in winter. Manipulation of the artificial light environment is ...
Dekun Kong,Li Cui,Xiaozheng Wang et al.
Dekun Kong et al.
Introduction: Plant-fungal interactions stimulate endophytic fungi to produce a plethora of metabolites that enhance plant growth and improve stress resistance. Opines, naturally occurring compounds formed through the con...
Trends, clinicopathological features, surgical treatment patterns and prognoses of early-onset versus late-onset gastric cancer: A retrospective cohort study [0.03%]
早期与晚期胃癌的流行趋势、临床病理特征、手术治疗模式及预后：一项回顾性队列研究
Yingxue Liu,Xiaoyan Zhang,Lu Gan et al.
Yingxue Liu et al.
Introduction: This study investigates the differences between early-onset gastric carcinoma (EOGC) and late-onset gastric carcinoma (LOGC) by examining trends, demographics, clinical and molecular features, treatments, an...
Interleukin-10 deficiency suppresses colorectal cancer metastasis by enriching gut Parabacteroides distasonis [0.03%]
肠道菌Parabacteroides distasonis通过抑制IL-10缺乏小鼠结直肠癌转移发挥肿瘤抑制作用
Jing Yu,Lili Feng,Zhanhao Luo et al.
Jing Yu et al.
Introduction: The intricate interplay of interleukin-10 (IL-10) and gut microbiota influences tumor development and progression, yet the impacts on colorectal cancer (CRC) metastasis remain incompletely understood. ...
miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades [0.03%]
微RNA miR-3606-3p通过整合抑制整联蛋白/FAK、p-AKT/p-ERK和TGF-β信号级联回归皮肤纤维化
Yahui Chen,Yiyi Gong,Mengkun Shi et al.
Yahui Chen et al.
Introduction: Fibroblast abnormalities are crucial causes of skin fibrosis, including systemic sclerosis (SSc) and keloids. However, their mechanisms, including underlying microRNA regulatory mechanisms, remain elusive. ...