Tissue-specific metabolite profiling reveals diverse metabolic response under N deficiency and high temperature stress in soybean [0.03%]
组织特异性代谢谱分析揭示了大豆氮素缺乏和高温胁迫下的多样代谢响应
Hamza Tariq,Muhammad Saqib Bilal,Lei Wang et al.
Hamza Tariq et al.
Introduction: Climate change has increased the incidence of compound stresses, including the co-occurrence of nitrogen deficiency (-N) and high temperature (HT), which severely reduce plant productivity. Studies have prim...
Lactiplantibacillus plantarum WY2401 promotes myogenesis via riboflavin-mediated modulation of METTL3-dependent mRNA m6A methylation [0.03%]
植物乳桿菌WY2401通过核糖醇介导的METTL3依赖性mRNA m6A甲基化调节促进肌细胞生成
Jiaqi Liu,Tongyudan Yang,Fangfang Lou et al.
Jiaqi Liu et al.
Introduction: Lactiplantibacillus plantarum (L. plantarum) is a well-characterized probiotic with a long history of safe application, exhibiting prominent potential in improving skeletal muscle function. As the most preva...
Targeting DDAH II with Puerarin ameliorates doxorubicin-induced endothelial damage and ferroptosis through ADMA/NOS dysregulation rescue [0.03%]
通过靶向DDAH II调控ADMA/NOS恢复正常水平从而改善紫杉醇诱导的内皮细胞损伤及铁死亡
Lewei Guan,Xuanzhi Cheng,Yichen Hu et al.
Lewei Guan et al.
Introduction: The ADMA/DDAHII/eNOS/NO pathway plays a pivotal role in maintaining the vascular endothelial structure and functional integrity, which might become a target attacked doxorubicin (Dox)-induced endotheliotoxic...
tRF-28-ZJ47D112Z4DZ suppresses gastric cancer progression via Ago2-mediated regulation of the CCND1-associated cell cycle pathway and serves as a complementary plasma biomarker [0.03%]
通过Ago2介导的CCND1相关细胞周期途径调控抑制胃癌进展并作为互补性血浆生物标志物的tRF-28-ZJ47D112Z4DZ
Xiuchong Yu,Jianing Tong,Yaoyao Xie et al.
Xiuchong Yu et al.
Introduction: Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, highlighting the need for improved non-invasive biomarkers for early detection and prognostic evaluation. tRNA-derived fragm...
miR149-5p: A hepatocyte EXOmotif sequence containing microRNA that attenuates liver fibrosis by specifically targeting PDGFRB in HSCs [0.03%]
miR149-5p：一种含有肝细胞EXOmotif序列的微小核糖核酸，可通过特异性靶向活化肝星状细胞中的血小板衍生生长因子受体β来减轻肝纤维化
Ji-Chao Zhou,An-Jian Xu,Jing Miao et al.
Ji-Chao Zhou et al.
Introduction: Liver fibrosis is a progressive pathological process driven by liver injury, including viral hepatitis and metabolic dysfunction-associated steatohepatitis (MASH), and can progress to cirrhosis, liver failur...
Irrigation and nitrogen management shape cropland efficiency-sustainability synergies in China [0.03%]
灌溉和氮素管理塑造了中国农地效率-可持续性的协同关系
Chuanbin Liang,Honghang Zhang,Wenxin Zhang et al.
Chuanbin Liang et al.
Introduction: Cropland systems face the challenge of providing adequate nutrition while managing environmental constraints, such as climate change and water scarcity. In China, where agricultural production supports a lar...
Activating Sigma1R by fluoxetine suppresses neuronal ferroptosis in epilepsy by inhibiting MDM2-mediated GPX4 ubiquitination [0.03%]
氟西汀通过抑制MDM2介导的GPX4泛素化激活Sigma1R抑制癫痫神经元铁死亡
Yuxiang Li,Cong Wang,Mengying Huang et al.
Yuxiang Li et al.
Introduction: Epilepsy affects more than 70 million individuals worldwide, contributing to early mortality, disability, and cognitive impairment. Antidepressants have been explored for epilepsy treatment, although their e...
Mouse models of aortic aneurysm and dissection: pathophysiological insights and translational perspectives [0.03%]
主动脉瘤和夹层的鼠类模型：病理生理学见解与转化视角
Chenyang He,Hiromi Yanagisawa,Tzung K Hsiai et al.
Chenyang He et al.
Background: Aortic aneurysm (AA) and aortic dissection (AD) are catastrophic aortic disorders characterized by progressive structural weakening or acute medial tearing, often resulting in rupture and high mortality. Their...
Spatiotemporal-specific DNA methylation and small RNAs are involved to regulate cell cycle progression and organ development of cucumber (Cucumis sativus L.) [0.03%]
时空特异性的DNA甲基化和小RNA通过调控黄瓜细胞周期进程参与器官建成调节
Xiaotao Ding,Yueying Mao,Yongxue Zhang et al.
Xiaotao Ding et al.
Introduction: Cucumber fruits, with a relatively high rate of fruit expansion, are harvested at an early developmental stage once moderately expanded. Although DNA methylation regulating fruit ripening has been well studi...
Immune cell dynamics in myocardial infarction: mechanisms, therapeutic targets, and translational Perspectives [0.03%]
心肌梗死中的免疫细胞动态变化：机制、治疗靶点和转化视角
Yue Ran,Yuexin Luo,Yumo Chen et al.
Yue Ran et al.
Background: Myocardial infarction (MI) triggers a complex and dynamic immune response involving both innate and adaptive immune cells. Among these, macrophages (Mφ), neutrophils, dendritic cells, and mast cells play esse...