The novel synbiotic (Lactiplantibacillus plantarum and galacto-oligosaccharides) ameliorates obesity-related metabolic dysfunction: Arginine as a key mediator signaling molecule [0.03%]
新型益生元协同组合（植物乳杆菌和半乳糖低聚糖）改善肥胖相关代谢紊乱：精氨酸作为关键信号分子介导上述作用
Renjie Shi,Jiangpeng Wei,Jin Ye et al.
Renjie Shi et al.
Objective: This study aimed to develop a novel synbiotic composed of Lactiplantibacillus plantarum LLY-606 and galacto-oligosaccharides (GOS) to improve lipid metabolism in obesity. Design Through genome-wide analysis usi...
Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relation between physical frailty and neuropsychiatric disorders [0.03%]
遗传机制、脑结构和周围生物标志物介导了身体脆弱性和神经精神障碍之间的关系
Pei-Yang Gao,Yan Fu,Xiao-Yu He et al.
Pei-Yang Gao et al.
Introduction: Physical frailty, which is characterized by multisystem functional decline, has emerged as a significant risk factor for adverse health outcomes. However, the relationship among physical frailty, brain funct...
Optimized stereoelectroencephalography-guided thermocoagulation versus anterior temporal lobectomy in mesial temporal epilepsy: A pilot randomized controlled study [0.03%]
优化的立体脑电图引导下热凝术与颞叶前侧切除术治疗内侧颞叶癫痫的疗效对比：一项随机对照研究
Yongzhi Shan,Jianwei Shi,Tianren Wang et al.
Yongzhi Shan et al.
Introduction: Anterior temporal lobectomy (ATL) is the standard surgical treatment for drug-resistant mesial temporal lobe epilepsy (MTLE); however, it is associated with cognitive decline and visual field deficits. In th...
Nan Li,Jianpeng Zhuang,Jiayi Wu et al.
Nan Li et al.
Introduction: To cope with the host's stressful environment and immune clearance, some drug-resistant bacteria have reduced their virulence. Protein post-translational modifications (PTMs) are known to regulate numerous c...
The impacts of long-term carbon disulfide exposure on glucose homeostasis and type 2 diabetes: a multifaceted gene-environment-lifestyle interaction study of Chinese adults [0.03%]
长期二硫化碳暴露对中国成年人糖代谢的影响及糖尿病的发病机制研究：一项多因素基因-环境-生活方式交互作用研究
Yueru Yang,Jiahao Song,Yongfang Zhang et al.
Yueru Yang et al.
Introduction: The long-term impacts of exposure to carbon disulfide (CS2), a highly concerning air toxicant listed by the Clean Air Act, and its interactions with genetic susceptibility and lifestyle on glucose homeostasi...
Guanglin Cui,Jiali Nie,Huihui Li et al.
Guanglin Cui et al.
Background: Fulminant myocarditis (FM) is the most severe form of myocarditis, characterized by rapid clinical progression and circulatory instability. However, its pathological features and their relationship to clinical...
Shikonin nasal spray film preparation promoted the repair of nasal mucosal injury by the interaction of shikonin with interleukin-6 [0.03%]
漆酚鼻喷雾膜促进通过与白细胞介素-6相互作用修复鼻粘膜损伤
Tao Gao,Qingye Jiang,Bin Zhang et al.
Tao Gao et al.
Introduction: Nasal spray films, an innovative formulation in recent years, have garnered significant acclaim from patients with nasal mucosal injury because it integrate the benefits of spray and film formulation, offeri...
Dietary n-3 polyunsaturated fatty acids intervention ameliorates cognitive dysfunction in db/db mice by mitigating cortical insulin resistance, mitochondrial dysfunction, and energy metabolism impairment [0.03%]
饮食中的n-3多不饱和脂肪酸干预通过减轻皮质胰岛素抵抗、线粒体功能障碍和能量代谢障碍来改善db/db小鼠的认知功能障碍
Yu Liu,Xiaojun Ma,Jingjing Xu et al.
Yu Liu et al.
Introduction: Cognitive dysfunction is a prevalent complication associated with Type 2 Diabetes Mellitus (T2DM). Cognitive dysfunction in patients with T2DM not only severely impacts their quality of life but also imposes...
Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization [0.03%]
乳酸菌约翰逊菌源性细胞外囊泡携带GAPDH通过调节巨噬细胞极化来抵抗溃疡性结肠炎
Shiyu Tao,Mengzhen Song,Jinping Fan et al.
Shiyu Tao et al.
Introduction: Ulcerative colitis (UC) is a major inflammatory condition worldwide. Objectives: The purpose of this study was to investi...
S-sulfhydration: Novel insights into the antioxidant and antiinflammation in age-related diseases [0.03%]
S-硫化作用：年龄相关疾病抗氧化和抗炎的新见解
Fei Liu,Lan Li,Longhui Yuan et al.
Fei Liu et al.
Background: Hydrogen sulfide (H2S) and hydrogen polysulfide-induced S-sulfhydration are critical posttranslational modifications that specifically target cysteine residues within proteins. Degenerative diseases are often ...