Bioactivity and multi-omics profiling of purslane-derived nanovesicles with therapeutic implications in diabetic wounds [0.03%]
具有治疗糖尿病伤口潜力的_PORTULACA OLERACEA_来源纳米囊泡的生物活性及多组学分析
Yang Song,Fengya Wang,Junhao Xia et al.
Yang Song et al.
Introduction: As an emerging natural nanomedicine, traditional Chinese medicine-derived exosome-like nanovesicles have shown unique potential in the treatment of chronic non-healing wounds due to their advantages such as ...
Berberine suppresses colorectal cancer progression by inducing ferroptosis-mediated energy metabolism disorders [0.03%]
小檗碱通过诱导铁死亡介导的能量代谢障碍抑制结直肠癌进展
Qiang Sun,Kerong Tu,Qiqi Xu et al.
Qiang Sun et al.
Introduction: Berberine (BBR), the predominant isoquinoline alkaloid in Coptidis Rhizoma, exhibits remarkable anti- colorectal cancer (CRC) activity. However, whether BBR triggers CRC cell death through ferroptosis-associ...
Depletion of myeloid-derived Zbtb46+ cells improves glycemic control in obesity via the DPP4/GLP-1 pathway [0.03%]
通过DPP4 / GLP-1途径耗尽髓样Zbtb46+细胞可改善肥胖患者的血糖控制能力
Shindy Soedono,Hoang Nguyet Dan Vo,Jiyeon Chang et al.
Shindy Soedono et al.
Introduction: Adipose tissue (AT) immune cells regulate metabolic functions in obesity through both inflammatory and non-inflammatory pathways. However, the specific roles and mechanisms of individual AT immune cell types...
Heterogeneity of urinary system tumors: novel avenues for targeted therapy and precision medicine [0.03%]
泌尿系统肿瘤的异质性：靶向治疗和精准医学的新途径
Hao Chen,Yang Weng,Donghan Zheng et al.
Hao Chen et al.
Background: Urinary system tumors, including bladder, kidney, and prostate cancers, impose a substantial health burden worldwide and exhibit significant molecular and genetic heterogeneity. ...
Divergence between neural and retinal lineage specification during human brain development by signal Transduction [0.03%]
人脑发育期间神经系和视网膜谱系细胞分化过程中的信号转导差异性研究
Ki Hong Nam,Sang Ah Yi,Lin-Fan Xiao et al.
Ki Hong Nam et al.
Introduction: The physiological functions of p70 S6 kinase 1 (S6K1) have been extensively studied in S6K1-deficient mice. However, there is limited evidence demonstrating the influence of S6K1 deletion on human brain deve...
Active polymerization regions of G and S monolignols show different temporal and spatial change patterns in the multicellular space during lignification and its inhibition of the fruit flesh [0.03%]
果肉层木质化过程中G型和S型单木质素活性聚合区域时空变化模式及其抑制效应研究
Jiayue Jin,Yibo Liu,Weinan Huang et al.
Jiayue Jin et al.
Introduction: Some fruits are vulnerable to chilling lignification during cold storage. However, the active polymerization cell regions of guaiacyl (G) and sinapyl (S) lignin units in fruit flesh during lignification and ...
Modeling homosynaptic and heterosynaptic plasticity with a single neuromemristive synapse [0.03%]
用单个神经忆阻突触建模同突触和异突触可塑性
Zubaer Ibna Mannan,Sami Azam,Ram Kaji Budhathoki et al.
Zubaer Ibna Mannan et al.
Introduction: Efforts are being made to design a brain-like intelligence due to its robustness, synaptic modification (i.e., learning and memory), analog synaptic multiplication, multi-state storage, ultra-low power consu...
Programmable microbial therapeutics: advances in engineered bacteria for targeted in vivo delivery and precision medicine [0.03%]
可编程微生物疗法：用于体内靶向递送和精准医疗的工程细菌的新进展
Lu Zhao,Jiaoyu Xin,Mingyang Hu et al.
Lu Zhao et al.
Background: Bioengineered bacteria have emerged as versatile, programmable platforms for in vivo drug delivery. By integrating gene editing, synthetic gene circuits, targeted surface modifications, and environment‑respon...
Screening of manganese-resistant bacteria and their synergistic effect with Koelreuteria paniculata on remediation of manganese-contaminated soil [0.03%]
锰耐性菌的筛选及其与七叶树(Koelreuteria paniculata)联合修复受锰污染土壤的研究
Jinsong He,Jieyu Dong,Xiaohong Wu et al.
Jinsong He et al.
Introduction: Plant-microbe collaborative remediation is a highly promising heavy metal remediation strategy. However, its remediation efficiency for manganese (Mn) tailings and its underlying mechanism remain inadequatel...
KRAS/ACTN4/p65-NR2A axis mediates glutamine-glutamate metabolic coupling between schwann cells and pancreatic cancer promoting perineural invasion [0.03%]
KRAS/ACTN4/p65-NR2A轴介导雪旺细胞与胰腺癌之间的谷氨酰胺-谷氨酸代谢偶联从而促进癌性神经侵犯
Zhenfeng Tian,Mingxin Su,Miao Yu et al.
Zhenfeng Tian et al.
Introduction: Pancreatic ductal adenocarcinoma (PDAC) exhibits aggressive perineural invasion (PNI), a hallmark of poor prognosis observed in 70-100% of cases. Schwann cells (SCs), key components of the tumor microenviron...