Bio-friendly multi-stimuli responsive α-CD polymer-gated mesoporous carbon nanoherbicides for enhanced paraquat delivery [0.03%]
生物友好型多刺激响应α-环糊精聚合物 gate 涂层介孔碳纳米除草剂用于增强百草枯输送
Jiangtao Dong,Guoquan Wang,Xiaona Li et al.
Jiangtao Dong et al.
Introduction: Weeds seriously affect crop yield in global agricultural production. Paraquat (PQ), as one of low cost and highly effective herbicide, is forbidden or severely restricted in production and sales owing to its...
Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity [0.03%]
解析人参的抗肥胖成分：人参多糖和人参皂苷如何靶向肠道微生物以抑制高脂饮食引起的肥胖症状
Han-Yan Luo,Jing Fang,Wei-Hao Zhang et al.
Han-Yan Luo et al.
Introduction: Ginseng demonstrates therapeutic potential in treating obesity, with both experimental and clinical studies suggesting its anti-obesity effects are mediated by gut microbiota. Nonetheless, the specific chemi...
ORP5 promotes cardiac hypertrophy by regulating the activation of mTORC1 on lysosome [0.03%]
ORP5通过调节溶酶体上mTORC1的活化促进心室肥厚
Di Zhao,Ran Xu,Yufei Zhou et al.
Di Zhao et al.
Introduction: Oxysterol binding protein (OSBP)-related protein 5 (ORP5) mainly functions as a lipid transfer protein at membrane contact sites (MCS). ORP5 facilitates cell proliferation through the activation of mTORC1 si...
Key β1-4 galactosylated glycan receptors of SARS-CoV-2 and its inhibitor from the galactosylated glycoproteins of bovine milk [0.03%]
牛乳中半乳糖化糖蛋白的SARS-CoV-2关键β1-4半乳糖基甘露糖受体及其抑制剂
Hanjie Yu,Wentian Chen,Jian Shu et al.
Hanjie Yu et al.
Introduction: The binding of the spike (S) protein of SARS-CoV-2 to angiotensin-converting enzyme 2 (ACE2) is a critical stage in the process of infection. While previous studies indicated that the S protein and ACE2 are ...
Not only the top: Type I topoisomerases function in multiple tissues and organs development in plants [0.03%]
不止于顶端：植物I型拓扑异构酶在多种组织和器官发育中的功能
Hao Zhang,Lirong Tian,Yuru Ma et al.
Hao Zhang et al.
Background: DNA topoisomerases (TOPs) are essential components in a diverse range of biological processes including DNA replication, transcription and genome integrity. Although the functions and mechanisms of TOPs, parti...
Dual regulation of phaseol on osteoclast formation and osteoblast differentiation by targeting TAK1 kinase for osteoporosis treatment [0.03%]
Phaseolon通过靶向TAK1激酶调控破骨细胞形成及成骨细胞分化治疗骨质疏松
Lihua Tan,Zhimin Miao,Yuxin Zhao et al.
Lihua Tan et al.
Introduction: Osteoporosis is an osteolytic disorder resulting from an inequilibrium between osteoblast-mediated osteogenesis and osteoclast-driven bone absorption. Safe and effective approaches for osteoporosis managemen...
Linqi Zeng,Xiaokai Zhang,Zihang Huang et al.
Linqi Zeng et al.
Background: Cardiac fibrosis, including reactive fibrosis and replacement fibrosis, is a common pathological process in most cardiovascular diseases. The ubiquitin proteasome system (UPS) plays an important role in the de...
Unlocking biological insights from differentially expressed genes: Concepts, methods, and future perspectives [0.03%]
差异表达基因的生物解读：概念、方法和未来趋势
Huachun Yin,Hongrui Duo,Song Li et al.
Huachun Yin et al.
Background: Identifying differentially expressed genes (DEGs) is a core task of transcriptome analysis, as DEGs can reveal the molecular mechanisms underlying biological processes. However, interpreting the biological sig...
Cancer-associated fibroblasts regulate mitochondrial metabolism and inhibit chemosensitivity via ANGPTL4-IQGAP1 axis in prostate cancer [0.03%]
癌症相关成纤维细胞通过ANGPTL4-IQGAP1轴调节前列腺癌的线粒体代谢并抑制其化疗敏感性
Zhi Xiong,Rui-Lin Zhuang,Shun-Li Yu et al.
Zhi Xiong et al.
Introduction: Cancer-associated fibroblasts (CAFs) are a critical component of the tumor microenvironment, being implicated in enhancing tumor growth and fostering drug resistance. Nonetheless, the mechanisms underlying t...
Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis [0.03%]
asperosaponinVI通过抑制DNMT缓解GPX4低表达介导的成骨细胞铁死亡及糖尿病性骨质疏松症
Fanhao Wei,Binjia Ruan,Jian Dong et al.
Fanhao Wei et al.
Introduction: Diabetic osteoporosis (DOP) is an insidious complication of diabetes with limited therapeutic options. DOP is pathologically associated with various types of regulated cell death, but the precise role of fer...