Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis [0.03%]
通过抑制TNF/CELSR2/p65/Kla-HDAC1/EPAS1轴靶向间充质单核细胞衍生的巨噬细胞以增强胶质母细胞瘤对替莫唑胺的敏感性
Wei Gao,Xinmiao Long,Xiang Lin et al.
Wei Gao et al.
Introduction: Temozolomide (TMZ) resistance poses a significant challenge to the treatment of aggressive and highly lethal glioblastomas (GBM). Monocyte-derived Macrophages (MDM) within the tumor microenvironment are key ...
Anthocyanin accumulation differences in European pears caused by Phytochrome-interacting factor 3 (PcPIF3) promoter mutations under UV-B [0.03%]
紫外辐射B介导的PcPIF3启动子突变引起欧洲梨花青素积累差异性增强响应机制研究
Haowei Cao,Yingying Qu,Lei Guo et al.
Haowei Cao et al.
The phenomenon of red fading in late-stage red-skinned pear fruit development significantly impacts its value. This phenomenon also occurs in 'Starkrimson', albeit to a lesser extent compared to 'Red Bartlett' and other varieties. The reaso...
NSP6 regulates calcium overload-induced autophagic cell death and is regulated by KLHL22-mediated ubiquitination [0.03%]
NSP6通过KLHL22介导的泛素化调控钙超载诱导的细胞自噬死亡
Xingyu Tao,Yanan Wang,Jiangbo Jin et al.
Xingyu Tao et al.
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a substantial global threat. SARS-CoV-2 nonstructural proteins (NSPs) are essential for impeding the host replication mechanism while also a...
An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of Notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1/Akt signaling [0.03%]
一种可注射的纳米羟基磷灰石掺杂水凝胶，通过Notch1/Akt信号通路促进血管生成，持续释放人参皂苷R1以增强骨再生
Bizhi Tan,Xiao Liu,Shuai Chen et al.
Bizhi Tan et al.
Introduction: Notoginsenoside R1 (NGR1), a bioactive compound, exhibits significant pro-angiogenic potential, making it a promising candidate for treating various diseases. Since angiogenesis and osteogenesis are synergis...
Osteoimmunity-Regulating biospun 3D silk scaffold for bone regeneration in critical-size defects [0.03%]
调控骨免疫的三维再生丝素蛋白支架促进临界尺寸骨缺损修复
Qian Zhang,Zulan Liu,YuanYuan He et al.
Qian Zhang et al.
Introduction: Silk-based biomaterials have received a great deal of attention in tissue engineering research for bone repair. Current silk-based materials are typically derived from silk protein solutions, but the limited...
Induction of cellular senescence by androgen receptor agonist or antagonist is mediated via two novel common DYRK1A-DREAM and cyclin G2 signaling pathways in castration-resistant prostate cancer [0.03%]
雄激素受体激动剂或拮抗剂通过两种新的共同DYRK1A-DREAM和cyclin G2信号通路在去势抵抗性前列腺癌中诱导细胞衰老
Golnaz Atri Roozbahani,Mehdi Heidari Horestani,Katrin Schindler et al.
Golnaz Atri Roozbahani et al.
Background: Castration-resistant prostate cancer (CRPC) is a deadly disease that in addition to being resistant to androgen deprivation often exhibits also resistant to androgen receptor (AR)-antagonists. Supraphysiologic...
Revealing the multiple faces of LRG1: gene expression, structure, function, and therapeutic potential [0.03%]
揭示LRG1的多面性：基因表达、结构、功能和治疗潜力
Ding Wang,Di Di,Bo Jiang et al.
Ding Wang et al.
Background: As the structural characterization of the Leucine-rich alpha-2-glycoprotein 1 (LRG1) protein progresses, its functional diversity has been increasingly unveiled, highlighting its clinical relevance in elucidat...
Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes [0.03%]
抗霉素A通过破坏嘧啶体的形成来抑制α疱疹病毒的复制
Yong-Qi Guo,Meng-Hang Wang,Ning Tang et al.
Yong-Qi Guo et al.
Introduction: Alpha-herpesvirus poses significant health risks to humans and challenges to animal husbandry. Currently, the clinically approved antiviral drug Acyclovir exhibits limitations, including drug resistance and ...
The functions of gut microbiota-mediated bile acid metabolism in intestinal immunity [0.03%]
肠道微生物群介导的胆汁酸代谢在肠免疫中的作用
Yanmin He,Weike Shaoyong,Yanli Chen et al.
Yanmin He et al.
Background: Bile acids, derived from cholesterol in the liver, consist a steroidal core. Primary bile acids and secondary bile acids metabolized by the gut microbiota make up the bile acid pool, which modulate nuclear hor...
SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations [0.03%]
SARS-CoV-2损伤心肌细胞线粒体与后遗症期心血管表现之间的关联
Wenliang Che,Shuai Guo,Yanqun Wang et al.
Wenliang Che et al.
Introduction: With the COVID-19 pandemic becoming endemic, vigilance for Long COVID-related cardiovascular issues remains essential, though their specific pathophysiology is largely unexplored. ...