Protein palmitoylation in hepatic diseases: Functional insights and therapeutic strategies [0.03%]
蛋白质棕榈酰化在肝病中的功能作用及治疗策略
Ying Wang,Haoyuan Ma,Bowen Zhang et al.
Ying Wang et al.
Background: Liver pathologies represent a spectrum of conditions ranging from fatty liver to the aggressive hepatocellular carcinoma (HCC), as well as parasitic infections, which collectively pose substantial global healt...
Comprehensive analysis of heterogeneity and cell-cell interactions in Crohn's disease reveals novel location-specific insights [0.03%]
全面分析克罗恩病的异质性和细胞间相互作用揭示了新颖的位置特异性见解
Jing Feng,Li-Na He,Ruchen Yao et al.
Jing Feng et al.
Introduction: In Crohn's disease (CD), lesions are mainly distributed in a segmental manner, with the primary sites of involvement being the ileum and colon. Heterogeneity in colon and ileum results in location-specific c...
Lonicera caerulea genome reveals molecular mechanisms of freezing tolerance and anthocyanin biosynthesis [0.03%]
越橘基因组揭示了抗冻性和花青素生物合成的分子机制
Jing Wang,Xiaotong Wang,Yuwei Ma et al.
Jing Wang et al.
Introduction: Lonicera caerulea L. (blue honeysuckle) is a noteworthy fleshy-fruited tree and a prominent medicinal plant, which possesses notable characteristics such as exceptional resilience to winter conditions and ea...
Tianwang Guan,Yanting Jiang,Peinan Tu et al.
Tianwang Guan et al.
Introduction: Non-cancer events are important causes of competing mortality among cancer patients. However, the risk of non-cancer death and risk classification in middle-aged cancer patients is not clear. To comprehensiv...
Evaluating current status of network pharmacology for herbal medicine focusing on identifying mechanisms and therapeutic effects [0.03%]
聚焦作用机制和药效评价的中药网络药理学现状及挑战
Won-Yung Lee,Kwang-Il Park,Seon-Been Bak et al.
Won-Yung Lee et al.
Introduction: Network pharmacology has gained significant traction as a tool for identifying the mechanisms and therapeutic effects of herbal medicines. However, despite the usefulness of these approaches, their diversity...
Adiponectin deficiency prevents chronic colitis-associated colonic fibrosis via inhibiting CXCL13 production [0.03%]
脂联素缺乏通过抑制CXCL13产生来预防慢性结肠炎相关结肠纤维化
Haitao Xiao,Tianhang Xing,Miao Qiu et al.
Haitao Xiao et al.
Introduction: Colonic fibrosis is a long-term complication of inflammatory bowel disease (IBD), often leading to functional impairment, intestinal obstruction, and surgery. Adiponectin (APN) is an adipokine derived from a...
Targeting APJ drives BNIP3-PINK1-PARKIN induced mitophagy and improves systemic inflammatory bone loss [0.03%]
靶向APJ通过BNIP3-PINK1-PARKIN诱导线粒体自噬并改善全身性炎症骨丢失
Wentao Wang,Qing Wang,Wenming Li et al.
Wentao Wang et al.
Introduction: Inflammatory diseases, such as diabetes mellitus, rheumatoid arthritis, and inflammatory bowel disease, lead to systemic immune microenvironment disturbances, contributing to bone loss, yet the mechanisms by...
Non-destructive detection strategy of maize seed vigor based on seed phenotyping and the potential for accelerating breeding [0.03%]
基于种子表型的玉米种子活力无损检测策略及其在加速育种中的应用潜力
Keling Tu,Shaozhe Wen,Yanan Xu et al.
Keling Tu et al.
Introduction: Seeds are fundamental to agricultural production, and their vigor affects seedling quality, quantity, and crop yield. Accurate vigor assessment methods are crucial for agricultural productivity. ...
Loss of glomerular aldolase B in diabetic nephropathy promotes renal fibrosis via activating Akt/GSK/β-catenin axis [0.03%]
糖尿病肾病中糖酵解关键酶醛缩酶B的丢失促进肾纤维化发生发展
Minghui Liu,Wenwen Yang,Shuang Qu et al.
Minghui Liu et al.
Objective: Diabetic nephropathy (DN), characterized by a complex and multifaceted pathogenesis, stands as the foremost catalyst behind end-stage renal disease (ESRD). This study aims to analyze the level and non-metabolic...
Design of highly leaf-adhesive and anti-UV herbicide nanoformulation for enhanced herbicidal activity [0.03%]
一种设计用于增强除草剂活性的高效粘附叶片且抗紫外线的纳米制剂
Dongdong Li,Jianan Li,Hao Li et al.
Dongdong Li et al.
Introduction: Conventional pesticide formulations have been widely used to boost agricultural productivity, but their weak foliar adhesion and instability under UV light during spraying lead to low utilization rates and p...