Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis [0.03%]
芽孢杆菌及其代谢产物通过调节巨噬细胞极化对抗痛风性关节炎
Siyue Song,Kaiyue Shi,Moqi Fan et al.
Siyue Song et al.
Introduction: Gut microbiota modulation has recently been identified as a prospective avenue for the exploration of novel therapeutic strategies for the management of gout. Nevertheless, the application of a single specif...
Multi-omics analysis of glycolytic reprogramming and ROS dynamics in host-specific responses to Salmonella Typhi infection in mice [0.03%]
小鼠宿主特异性响应伤寒沙门氏菌感染的糖酵解重构及活性氧动态的多组学分析
Yanrui Bai,Wenxiu Liu,Zhiyuan Liu et al.
Yanrui Bai et al.
Introduction: Salmonella Typhi (S. Typhi), a Gram-negative, serves as the etiological agent of typhoid fever. In contrast to other Salmonella serovars, S. Typhi exclusively infects humans. However, the molecular interacti...
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer [0.03%]
血红素氧合酶1（HO-1）是逆转非小细胞肺癌顺铂耐药的药物靶点
Jie Mei,Hui-Xiang Tian,Xiao-Ye Zhang et al.
Jie Mei et al.
Introduction: Platinum-based drugs, the most widely used chemotherapeutic drugs in clinical oncology, have long faced the problem of drug resistance, which is urgently in need of resolution. Identifying biomarkers of drug...
Beyond the Brain: Exploring the multi-organ axes in Parkinson's disease pathogenesis [0.03%]
超越大脑：探索帕金森病发病机制中的多器官轴
Tingting Liu,Haojie Wu,Jianshe Wei
Tingting Liu
Background: Parkinson's Disease (PD), a complex neurodegenerative disorder, is increasingly recognized as a systemic condition involving multi-organ interactions. Emerging evidence highlights roles of organ-brain axes (lu...
Novel function of macrophage migration inhibitory factor in regulating post-infarct inflammation and the therapeutic significance [0.03%]
巨噬细胞迁移抑制因子调控心梗后炎症的新型功能及其治疗学意义
Ling Zhao,Guo-Li Du,Amanguli Ruze et al.
Ling Zhao et al.
Introduction: Recent studies indicate that macrophage migration inhibitory factor (MIF) has a dual role in myocardial infarction (MI), with different cellular sources of MIF influencing inflammation and healing differenti...
Trends, patterns, and risk factors of esophageal cancer mortality in China, 2008-2021: A national mortality Surveillance System data analysis [0.03%]
中国食管癌死亡率的流行趋势、模式和危险因素（2008—2021年）：全国死因监测系统数据的分析研究
Yunfei Jiao,Tinglu Wang,Lin Fu et al.
Yunfei Jiao et al.
Introduction: According to the International Agency for Research on Cancer, China had the highest mortality burden of esophageal cancer (EC) globally in 2022. ...
Association between dietary amino acid intake and the risk of metabolic dysfunction-associated steatotic liver disease [0.03%]
膳食氨基酸摄入与代谢功能紊乱相关脂肪肝病风险的关系研究
Ruoqi Zhou,Xinrong Zhang,Xinxin Liu et al.
Ruoqi Zhou et al.
Introduction: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is becoming the major chronic liver disease, and diet plays crucial role in MASLD prevention. ...
Fe-S cluster deficiency drives small colony variant formation in persistent infections [0.03%]
缺铁诱导的硫铁簇缺陷驱动了持续性感染中的小菌落变异体的形成
Tianchi Chen,Zhiyi Ye,Weiyi Huang et al.
Tianchi Chen et al.
Introduction: Small colony variants (SCVs) of Staphylococcus aureus (S. aureus) are associated with persistent infections and poor clinical outcomes. The mechanisms driving stable SCV formation remain poorly understood, p...
Overexpression of soybean flavonoid 3'-hydroxylase enhances plant salt tolerance by promoting ascorbic acid biosynthesis [0.03%]
大豆黄酮3′-羟基酶的过表达通过促进抗坏血酸生物合成来增强植物耐盐性
Jianfei Wu,Xiaokun Wang,Jiawei Xu et al.
Jianfei Wu et al.
Introduction: Salt stress is a major cause of crop loss. Soybean (Glycine max), a globally vital legume crop, faces mounting yield constraints due to soil salinization. It is known that the flavonoid biosynthesis pathway ...
Mechanical mechanics-reclaiming a new battlefield for chronic liver disease [0.03%]
力学力学——为慢性肝病重新争取新的战场
Yiheng Zhang,Tianle Ma,XingXing Lu et al.
Yiheng Zhang et al.
Background: In the 21st century, significant breakthroughs have been made in the research of chronic liver disease. New biochemical markers of pathogenicity and corresponding drugs continue to emerge. However, current tre...