Reconceptualizing Endothelial-to-mesenchymal transition in atherosclerosis: Signaling pathways and prospective targeting strategies [0.03%]
从信号通路到靶向策略：动脉粥样硬化中内皮间质转化的概念更新与发展前景
Nanlin You,Guohao Liu,Mengchen Yu et al.
Nanlin You et al.
Background: The modification of endothelial cells (ECs) biological function under pathogenic conditions leads to the expression of mesenchymal stromal cells (MSCs) markers, defined as endothelial-to-mesenchymal transition...
Xiao-Han Zhou,Ya-Xi Luo,Xiu-Qing Yao
Xiao-Han Zhou
Background: Exercise enhances health by supporting homeostasis, bolstering defenses, and aiding disease recovery. It activates autophagy, a conserved cellular process essential for maintaining balance, while dysregulated ...
Exploring CAR-macrophages in non-tumor diseases: Therapeutic potential beyond cancer [0.03%]
基于CAR-macrophage的免疫疗法在肿瘤外疾病中的应用及转化前景探讨
Yizhao Chen,Qianling Xin,Mengjuan Zhu et al.
Yizhao Chen et al.
Background: After significant advancements in tumor treatment, personalized cell therapy based on chimeric antigen receptors (CAR) holds promise for transforming the management of various diseases. CAR-T therapy, the firs...
Unveiling novel antimicrobial peptides from the ruminant gastrointestinal microbiomes: A deep learning-driven approach yields an anti-MRSA candidate [0.03%]
来自反刍动物胃肠微生物组的新型抗菌肽的发现：深度学习驱动的方法筛选出潜在抗耐甲氧西林金黄色葡萄球菌候选抗菌肽
Hong Shen,Yanru Li,Qingjie Pi et al.
Hong Shen et al.
Introduction: Antimicrobial peptides (AMPs) present a promising avenue to combat the growing threat of antibiotic resistance. The ruminant gastrointestinal microbiome serves as a unique ecosystem that offers untapped pote...
Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signalling [0.03%]
Parkin通过调节PD-1 / PD-L1信号传导来调节肝细胞癌微环境
Guiqin Ye,Xin Sun,Jiuzhou Li et al.
Guiqin Ye et al.
Introduction: Parkin-mediated mitophagy is essential for the clearance of damaged mitochondria, and it inhibits tumour development. The role of mitophagy in modulating tumour immunity is becoming clearer, but the underlyi...
Eicosapentaenoic acid enhances intestinal stem cell-mediated colonic epithelial regeneration by activating the LSD1-WNT signaling pathway [0.03%]
二十碳五烯酸通过激活LSD1-WNT信号通路增强肠干细胞介导的结肠上皮再生
Dan Wang,Nianbang Wu,Pei Li et al.
Dan Wang et al.
Introduction: Inflammatory bowel disease (IBD) is often associated with impaired proliferation and differentiation of intestinal stem cells (ISCs). Eicosapentaenoic acid (EPA), which is predominantly found in fish oil, ha...
Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells [0.03%]
多组学方法揭示转化生长因子-β信号驱动的牙周组织干细胞衰老机制
Bo Li,Wei Li,Yueqi Liao et al.
Bo Li et al.
Introduction: The periodontal ligament (PDL), a dynamic connective tissue that anchors teeth to the alveolar bone, enables tooth retention and facilitates continuous turnover. The integrity of the periodontium is maintain...
5-Aminolevulinic acid improves strawberry salt tolerance through a NO-H2O2 signaling circuit regulated by FaWRKY70 and FaWRKY40 [0.03%]
叶绿素酸改善草莓耐盐性通过FaWRKY70和FaWRKY40调控的NO-H2O2信号通路
Hao Yang,Jianting Zhang,Yan Zhong et al.
Hao Yang et al.
Introduction: 5-Aminolevulinic acid (ALA) is an essential biosynthetic precursor of tetrapyrrole compounds, naturally occurring in all living organisms. It has also been suggested as a new plant growth regulator. Treatmen...
Elevated EBF2 in mouse but not pig drives the progressive brown fat lineage specification via chromatin activation [0.03%]
EBF2在小鼠而非猪中上调通过染色质激活驱动渐进的棕色脂肪细胞谱系决定
Yinlong Liao,Zhelun Peng,Shanshan Fu et al.
Yinlong Liao et al.
Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis, but it is absent in some mammals, including pigs. During development, BAT progenitors are derived from paired box 7 (Pax7)-expressing somitic mesodermal stem cells, ...
D-Mannose-Mediated metabolic pathways sustain the molecular signatures of sperm function and fertilization [0.03%]
D-半乳糖介导的代谢通路维持了精子功能和受精的分子标志物
Wenlong Zhao,Nihao Gu,Xueyuan Liu et al.
Wenlong Zhao et al.
Introduction: Mammalian sperm within a single ejaculate exhibit significant heterogeneity, with only a subset possessing the molecular characteristics required for successful fertilization. Identifying the defining traits...