LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria [0.03%]
一种针对临床多重耐药细菌的广谱抗菌多肽LTX-315
Yang Tang,Chen Yang,Jiamin Zhao et al.
Yang Tang et al.
Introduction: Infections stemming from multidrug-resistant bacteria present a substantial threat to public health today. Discovering or synthesizing novel compounds is crucial to alleviate this pressing situation. ...
Fangchinoline eliminates intracellular Salmonella by enhancing lysosomal function via the AMPK-mTORC1-TFEB axis [0.03%]
方樟碱通过AMPK-mTORC1-TFEB轴增强溶酶体功能消除胞内沙门氏菌
Mengping He,Huihui Wu,Tianqi Xu et al.
Mengping He et al.
Introduction: Salmonella, a foodborne zoonotic pathogen, is a significant cause of morbidity and mortality in animals and humans globally. With the prevalence of multidrug-resistant strains, Salmonellosis has become a for...
Dimeric guaianolide sesquiterpenoids from the flowers of Chrysanthemum indicum ameliorate hepatic steatosis through mitigating SIRT1-mediated lipid accumulation and ferroptosis [0.03%]
千里光菊花朵中的二聚guaianolide倍半萜类化合物通过减轻SIRT1介导的脂质积累和铁死亡来改善肝脂肪变性
Yu Liu,Fei Zhou,Haoyu Zhao et al.
Yu Liu et al.
Introduction: Non-alcoholic fatty liver disease (NAFLD) acts as the primary contributor to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and potentially hepatocellular carcinoma. The flowers of Chrysanthemum indicum...
Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection [0.03%]
抗氧化剂牛磺酸通过上调OGT/Gpx4信号通路抑制前交叉韧带切断诱导的骨关节炎软骨细胞铁死亡
Xuchang Zhou,Yajing Yang,Xu Qiu et al.
Xuchang Zhou et al.
Objective: The aim of this study was to investigate the potential molecular mechanisms by which taurine protects against cartilage degeneration. Methods: ...
Yue Liu,Huabing Tan,Jingyuan Dai et al.
Yue Liu et al.
Background: Cancer immunotherapy has emerged as a groundbreaking approach in cancer treatment, primarily realized through the manipulation of immune cells, notably T cell adoption and immune checkpoint blockade. Neverthel...
Odontogenic exosomes simulating the developmental microenvironment promote complete regeneration of pulp-dentin complex in vivo [0.03%]
模拟发育微环境的牙源性外泌体促进活体牙髓-牙本质复合体的完全再生
Yifan Wang,Jing Mao,Yujie Wang et al.
Yifan Wang et al.
Introduction: Establishing an optimized regenerative microenvironment for pulp-dentin complex engineering has become increasingly critical. Recently, exosomes have emerged as favorable biomimetic nanotherapeutic tools to ...
Reconciliation of wheat 660K and 90K SNP arrays and their utilization in dough rheological properties of bread wheat [0.03%]
六倍体小麦660K和90K两个SNP芯片的兼容性及其在面包小麦粉质特性上的应用研究
Congwei Sun,Zhenhai Jing,Xiaoqian Chen et al.
Congwei Sun et al.
Introduction: High-density Wheat 660K and 90K SNP arrays are powerful tools for understanding the genetic basis of wheat traits. However, their inconsistantly physical positions that were caused by different versions of C...
RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system [0.03%]
神经退行性疾病中的RNA甲基化修饰及其酶系统研究
Lu Liu,Yu-Jia Zhao,Feng Zhang
Lu Liu
Background: Neurodegenerative diseases (NDs) constitute a significant public health challenge, as they are increasingly contributing to global mortality and morbidity, particularly among the elderly population. Pathogenes...
Regulation of important natural products biosynthesis by WRKY transcription factors in plants [0.03%]
植物WRKY转录因子对重要次生代谢产物生物合成的调控研究进展
Mingyu Li,Yiming Shao,Baiwei Pan et al.
Mingyu Li et al.
Background: Plants produce abundant natural products, among which are species-specific and diversified secondary metabolites that are essential for growth and development, as well as adaptation to adversity and ecology. M...
GABAFG isolated fom ginseng ameliorates type 2 diabetes mellitus by modulating gut microbiota and autophagy-lysosome pathway [0.03%]
从人参中分离的GABAFG通过调节肠道微生物群和自噬溶酶体途径改善2型糖尿病
Meng-Han Qi,Hai-Yan Zhang,Yun-Yi Hou et al.
Meng-Han Qi et al.
Introduction: Hyperglycemia and hyperlipidemia are the hallmarks of type 2 diabetes mellitus (T2DM). T2DM is a systemic metabolic disease caused by insulin resistance and malfunctioning pancreatic β-cells. Although ginse...