Basophilic exosomes promote SLE development via exacerbating B cell activation through the lncRNA ENST00000537616/miR-330-5p/KRAS axis [0.03%]
basophil-derived exosomal lncRNA ENST00000537616通过miR-330-5p/KRAS轴促进B细胞活化从而加剧系统性红斑狼疮的发展
Jiaxuan Chen,Shuxian Chen,Kangyuan Shen et al.
Jiaxuan Chen et al.
Introduction: Uncontrolled B-cell activation in systemic lupus erythematosus (SLE) induces autoantibody production and inflammation and causes tissue damage. Basophils have been shown to promote B cell activation in SLE; ...
S100B induces angiogenesis via the clathrin/FOXO1/β-catenin signaling pathway and contributes to Bevacizumab resistance in epithelial ovarian cancer [0.03%]
S100B通过网格蛋白/FOXO1/β-连环蛋白信号通路诱导血管生成并导致贝伐单抗耐药在卵巢上皮癌中的作用
Haoya Xu,Wenzhi Li,Huiran Yue et al.
Haoya Xu et al.
Introduction: Bevacizumab (BEV), the most common antiangiogenic agent for treating ovarian cancer, prolongs progression-free survival (PFS) but does not significantly improve overall survival (OS). Improving the limited c...
Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice [0.03%]
母体免疫激活后代小鼠肠道衍生色氨酸代谢产物丁酸异丙酯的产前补充剂可减轻结肠炎易感性
Ying He,Chen Ding,Bo Zhang et al.
Ying He et al.
Introduction: Maternal immune activation (MIA) impairs gut immune function in offspring, with maternal microbiota and their metabolites influencing intestinal development. Indole-3-propionic acid (IPA), a microbial metabo...
Parasympathetic pathway in melatonin regulation exogenous melatonin alleviates abnormal glucose metabolism in the breast muscle under long-term light exposure through the parasympathetic pathway [0.03%]
褪黑素调节副交感神经通路外源性褪黑素通过副交感神经通路缓解长期光照下胸部肌肉异常糖代谢
Miao Yu,Mengjie Xu,Guangju Wang et al.
Miao Yu et al.
Introduction: Human beings and animals have been exposed to long-term artificial lighting environments to induce glucose metabolism disorder. Melatonin (MT) is involved in the regulation of glucolipid metabolism, and can ...
Ciliary IFT88 inhibits intervertebral disc degeneration under excessive mechanical stress by regulating endplate cartilage calcification [0.03%]
纤毛IFT88通过调节终板软骨钙化抑制机械应力过载诱发的椎间盘退变
Zhi-Rui Dong,Jing Wang,Yu-Kai Huang et al.
Zhi-Rui Dong et al.
Introduction: Endplate cartilage is crucial for nutrient transport to intervertebral disc (IVD), and its calcification due to abnormal mechanical stress significantly contributes to intervertebral disc degeneration (IDD)....
Genomic landscape of paired primary and peritoneal metastatic lesions in gastric cancer highlights evolutionary dynamics and mutational drivers [0.03%]
配对胃癌原发灶和腹膜转移灶的基因组景观揭示了进化动力学和突变驱动因素
Song Li,Weiwei Zhang,Qian Yang et al.
Song Li et al.
Introduction: Peritoneal metastasis is a prevalent form of gastric cancer spread, often resulting in poor outcomes. Due to the lack of clinical recommendation for surgery, current omics studies are limited to analyzing su...
Characterization of immune features and discovery of potential biomarkers for ankylosing spondylitis using deep plasma proteomics [0.03%]
利用深血浆蛋白质组学表征免疫特征并发现银屑病关节炎的潜在生物标志物
Xiaohan Xu,Wanlin Liu,Bo Pang et al.
Xiaohan Xu et al.
Introduction: Ankylosing spondylitis (AS) is a systemic inflammatory disorder that predominantly involves the axial skeleton, often leading to irreversible structural damage and disability. Although several therapeutic me...
In newly diagnosed diabetes, hyperglycemia is associated with increased brain iron deposition, measured by MRI-based Quantitative Susceptibility Mapping (QSM) [0.03%]
在新诊断的糖尿病患者中，高血糖与基于MRI的定量磁敏感度mapping(QSM)测量的脑铁沉积增加有关
Maria Agnese Pirozzi,Fabrizio Esposito,Francesca Trojsi et al.
Maria Agnese Pirozzi et al.
Background: Long-term Type 2 diabetes mellitus (T2DM) affects multiple organs and systems throughout the body, including the cardiovascular, renal, and nervous systems. In the brain, T2DM impacts brain function, leading t...
Research progress on immunoprotective mechanisms of enteric fever and vaccine development [0.03%]
伤寒免疫保护机制研究进展及疫苗开发方向
Ying Chen,Lingwei Chen,Yanzhen Lin et al.
Ying Chen et al.
Background: Enteric fever remains a serious global health challenge. Effective control of enteric fever depends on clean water and proper sanitation, which remains unattainable in resource-limited settings. Vaccination is...
Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson's disease [0.03%]
纤连蛋白通过α5β3整合素促进帕金森病中α-突触核蛋白聚集和线粒体功能障碍
Zifeng Huang,Jialing Zheng,Feilan Yuan et al.
Zifeng Huang et al.
Introduction: Blood-brain barrier(BBB) disruption promotes the influx of the fibrinogen(FG); however, it remains unknown whether FG deposit contributes to neurodegeneration in Parkinson's disease(PD). ...