Efficient derivation of stable sheep embryonic stem cells opens a new avenue for agricultural and biomedical application [0.03%]
高效的羊胚胎干细胞分化法为农业和生物医学应用开辟了新途径
Miaohan Jin,Shuhong Huang,Shiwei Zhou et al.
Miaohan Jin et al.
Introduction: Embryonic stem cells (ESCs), capable of generating all adult cell types, hold transformative potential for agriculture and biomedicine. However, stable sheep ESCs derivation remains challenging, limiting the...
Astaxanthin biofortification enhances tobacco tolerance to lead stress through boosting antioxidant defense, reducing Pb accumulation, and modulating detoxification pathways [0.03%]
虾青素富集可增强烟草对铅胁迫的耐受性：通过促进抗氧化防御、减少铅积累和调节解毒途径实现
Zhongyang Du,Mengjing Liang,Xiaodan Wang et al.
Zhongyang Du et al.
Introduction: Heavy metal pollution including lead (Pb) has become one of the serious global issues threatening food security, human health, and the ecosystem. Exogenous application of astaxanthin (ATX), a potent natural ...
SUMOylation modulates the dual functions of Krüppel homolog 1 in transcriptional regulation of Broad-Complex expression [0.03%]
SUMO化调节Krüppel同源物1在Broad-复杂表达转录调控中的双重功能
Qianyu He,Jinxia Chen,Shanshan Chen et al.
Qianyu He et al.
Introduction: Insects undergo intricate metamorphosis processes governed by hormonal regulatory mechanisms, exemplified by the antagonistic actions of 20-hydroxyecdysone (20E) and juvenile hormone (JH). Krüppel homolog 1...
A machine learning platform for genotype-specific cardiotoxicity risk prediction using patient-derived iPSC-CMs [0.03%]
一种使用患者诱导多能干细胞心肌细胞进行基因型特异性心脏毒性的风险预测的机器学习平台
Yun-Gwi Park,Na Kyeong Park,Youngsun Lee et al.
Yun-Gwi Park et al.
Introduction: Drug-induced Torsades de Pointes (TdP) has led to withdrawal of several drugs from the market. Individuals with inherited cardiac channelopathies are at increased risk due to their underlying electrophysiolo...
Hypothalamic BCL6 signaling modulates energy homeostasis and metabolism by inhibiting STAT3 transcription [0.03%]
下丘脑BCL6信号通过抑制STAT3转录调节能量平衡和代谢
Hongdong Han,Qinge Li,Cong Wang et al.
Hongdong Han et al.
Introduction: B-cell leukemia/lymphoma 6 (BCL6) has been implicated in regulating energy metabolism in peripheral tissues; however, its role in the hypothalamic regulation of energy homeostasis remains poorly defined. ...
Biological potential and mechanisms of brain-expressed X-linked family proteins in cancers: an updated review [0.03%]
脑表达X染色体_linked蛋白家族在癌症中的生物潜能及机制：综述更新
Pingping Wang,Ziyan Chen,Hongyan Zhang et al.
Pingping Wang et al.
Background: Brain-Expressed X-linked (BEX) family proteins is a relative younger protein family in human being, with limited understanding of its pathophysiological functions in health and disease. So far, The human BEX f...
MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids [0.03%]
MeCP2调控异常会抑制皮层类器官的线粒体自噬并影响神经发育
Jing Zhou,Yuchun Liu,Xintao Jing et al.
Jing Zhou et al.
Introduction: Methylated CpG-binding protein 2 (MeCP2) plays a critical role in the normal development and function of the nervous system. Mutations in MeCP2 have been linked to neurodevelopmental disorders, potentially b...
Gut microbiota-mediated regulation of skeletal development: A review of mechanistic analysis and interventional strategies [0.03%]
肠道菌群介导骨骼发育调控的研究进展：机制分析与干预策略综述
Chongyuan Liu,Ya-Nan Yang,Shuang Guo et al.
Chongyuan Liu et al.
Background: The preadolescent period is a rapid and critical stage of skeletal development. Poor skeletal development during this period can exert profound impacts on children's growth, motor function, psychosocial adapta...
Gut microbiota-derived xanthohumol protects against heatstroke by inhibiting macrophage pyroptosis in mice [0.03%]
肠道菌群衍生的蛇麻醇通过抑制小鼠巨噬细胞焦亡保护机体免受中暑损伤
Wei Huang,Weidang Xie,Haixia Liu et al.
Wei Huang et al.
Background: Heatstroke is a critical illness induced by heat stress, characterized by circulatory failure and multiple organ dysfunctions. Accumulating evidence suggests that the pathophysiology of various diseases is clo...
The pro-cancer and immunosuppressive activity of macrophage-transformed cancer-associated fibroblasts in oral squamous cell carcinoma [0.03%]
口腔鳞状细胞癌中促肿瘤巨噬细胞转化的癌症相关成纤维细胞的促癌和免疫抑制活性
Haoyang Tian,Simin Zhao,Fujiao Nie et al.
Haoyang Tian et al.
Introduction: Cancer-associated fibroblasts (CAFs), as a crucial component of the tumor microenvironment (TME), exhibit heterogeneity, and macrophage-myofibroblast transition (MMT) has been demonstrated to be one of the o...