Molecular and cellular morphology of placenta unveils new mechanisms of reproductive immunology [0.03%]
胎盘的分子和细胞形态揭示了生殖免疫学的新机制
Penghao Li,Liting Zeng,Xiaomiao Yan et al.
Penghao Li et al.
Introduction: Despite of numerous studies of the placenta, some molecular and cellular characteristics, particularly the relationship among different cell types, have not been well understood. We aim to investigate the ba...
SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells [0.03%]
SCARB1通过连接胆固醇代谢介导的铁死亡抑制与肿瘤细胞的放射抵抗性将其串联在一起
Xiaojuan Mao,Jingwen Xiong,Mengjiao Cai et al.
Xiaojuan Mao et al.
Introduction: Ferroptosis is an iron-dependent form of cell death triggered by the excessive accumulation of lipid peroxides. Understanding the regulatory mechanisms of ferroptosis and developing strategies to target this...
A novel small molecule NJH-13 induces pyroptosis via the Ca2+ driven AKT-FOXO1-GSDME signaling pathway in NSCLC by targeting TRPV5 [0.03%]
一种新型小分子化合物NJH-13通过靶向TRPV5诱导非小细胞肺癌中Ca2+驱动的AKT-FOXO1-GSDME信号通路介导的细胞焦亡
Xianxiang Dong,Jiahui Nie,Aiying Huang et al.
Xianxiang Dong et al.
Introduction: Pyroptosis represents a mode of programmed necrotic cell death (PCD), mediated by members of gasdermin family (GSDMs), such as GSDME. It is emerging as a promising approach for combating cancer. Notably, GSD...
Development of novel broad-spectrum amphipathic antimicrobial peptides against multidrug-resistant bacteria through a rational combination strategy [0.03%]
通过合理的组合策略开发针对多重耐药细菌的新型广谱两亲性抗菌肽
Jing Zhang,Liang Luan,Youdong Xu et al.
Jing Zhang et al.
Introduction: In recent years, cationic amphipathic antimicrobial peptides (AMPs) have shown great promise in combating antibiotic resistance on account of their distinctive membrane-disruptive mechanism. However, the cli...
LMNA-related cardiomyopathy: From molecular pathology to cardiac gene therapy [0.03%]
LMNA相关的心肌病：从分子病理学到心脏基因治疗
Ze Wang,Jiahao Wu,Zhengyuan Lv et al.
Ze Wang et al.
Background: The genetic variants of LMNA cause an array of diseases that often affect the heart. LMNA-related cardiomyopathy exhibits high-penetrance and early-onset phenotypes that lead to late-stage heart failure or let...
Post-transcriptional and post-translational regulation of anthocyanin biosynthesis in sweetpotato by Ib-miR2111 and IbKFB: Implications for health promotion [0.03%]
Ib-miR2111和IbKFB对甘薯花青素生物合成的转录后和翻译后的调控：促进健康的意义
Ruimin Tang,Cailiang Zhao,Jingjian Dong et al.
Ruimin Tang et al.
Introduction: Sweetpotato (Ipomoea batatas (L.) Lam.) is a genetically intricate hexaploid crop. The purple-fleshed variety, enriched with anthocyanin pigments, is an outstanding source for creating high-value functional ...
Transcriptional regulation of Rankl by Txnip-Ecd in aging and diabetic related osteoporosis [0.03%]
Txnip-Ecd调节RANKL转录治疗与年龄及糖尿病相关的骨质疏松症
Xiankun Cao,Kexin Liu,Jinbo Yuan et al.
Xiankun Cao et al.
Introduction: Bone homeostasis between osteoclast bone resorption and osteoblastic bone formation is tightly regulated by a series of factors such as the receptor activator of nuclear factor-κB ligand (RANKL). Denosumab ...
Versatile platforms of mussel-inspired agarose scaffold for cell cultured meat [0.03%]
受牡蛎启发的琼脂糖支架在培养肉中的多功能应用研究
Kaihao You,Lianghua Xie,Jiaxin Li et al.
Kaihao You et al.
Introduction: Biomaterial scaffolds are critical for cell cultured meat production. polysaccharide scaffolds lack essential animal cell adhesion receptors, leading to significant challenges in cell proliferation and myoge...
Activation of sphingosine-1-phosphate receptor 2 (S1PR2) upregulates dihydropyrimidine dehydrogenase (DPD) expression in colon cancer cells [0.03%]
鞘氨醇-1-磷酸受体2(S1PR2)的激活通过上调结肠癌细胞中二氢嘧啶脱氢酶(DPD)的表达发挥作用
Zhi-Kun Guo,Xin-Feng Wu,Ming-Yong Tan et al.
Zhi-Kun Guo et al.
Introduction: Dihydropyrimidine dehydrogenase (DPD) is a major determinant of cancer 5-fluorouracyl (5-FU) resistance via its direct degradation. However, the mechanisms of tumoral DPD upregulation have not been fully und...
Mycotoxin toxicity and its alleviation strategy on female mammalian reproduction and fertility [0.03%]
霉菌毒素对雌性哺乳动物生殖和生育力毒害及缓解措施研究进展
Ping-Shuang Lu,Shao-Chen Sun
Ping-Shuang Lu
Background: Mycotoxin, a secondary metabolite of fungus, found worldwide and concerning in crops and food, causing multiple acute and chronic toxicities. Its toxic profile includes hepatotoxicity, carcinogenicity, teratog...