SAE1 emerges as a pan-cancer driver and key regulator of HCC metastasis [0.03%]
SAE1作为泛癌症驱动基因和肝细胞癌转移的关键调节因子浮现出来
Hao Zhuang,Yamei Dang,Li Sun et al.
Hao Zhuang et al.
Introduction: Dysregulation of SUMOylation is implicated in cancer progression. While the role of SUMO-activating enzyme (SAE) and its mechanisms in cancer remain unclear. ...
A novel peptide MIB1-223aa encoded by exosomal circMIB1 from cancer-associated fibroblasts drives triple-negative breast cancer metastasis and stemness via stabilizing MIB1 to activate Notch signaling [0.03%]
癌相关成纤维细胞来源的环状circMIB1衍生的小分子多肽MIB1-223aa通过稳定MIB1蛋白激活Notch信号驱动三阴性乳腺癌干细胞特性及转移的功能研究
Fangzhou Ye,Yiran Liang,Jianing Wang et al.
Fangzhou Ye et al.
Introduction: Emerging evidence has indicated that the complex interactions between tumor microenvironment (TME) and cancer cells play a pivotal role in driving tumor initiation and metastasis. Cancer associated fibroblas...
Advancements in bone organoids: perspectives on construction methodologies and application strategies [0.03%]
骨类器官的研究进展：构建方法及应用策略展望
Shuo Huang,Yufei Wu,Hui Zhao et al.
Shuo Huang et al.
Background: In clinical practice and research, bone defects due to tumor growth, trauma, and different pathological conditions are significant challenges. Although bone possesses an intrinsic capacity for regeneration, ex...
Burden of bacterial antimicrobial resistance in China: a systematic analysis from 1990 to 2021 and projections to 2050 [0.03%]
1990至2021年中国细菌耐药负担的系统分析及2050年预测
Jian Xu,Jingyu Liu,Xiaowei Li et al.
Jian Xu et al.
Introduction: Antimicrobial resistance (AMR) has emerged as a critical health challenge; however, there is a paucity of in-depth reports outlining its burden and trends in China. ...
Multi-algorithm consensus classification identifies three distinct acute liver failure subtypes with differential treatment responses: a multi-database cohort study [0.03%]
基于多算法共识分类的急性肝衰竭亚型及其不同的治疗反应：一项多数据库队列研究
Ying Yang,Wei Yang,Bo Tang et al.
Ying Yang et al.
Background: Acute liver failure (ALF) is a heterogeneous syndrome with high mortality. Current prognostic models fail to capture pathophysiological heterogeneity, necessitating refined patient stratification and personali...
Heterojunction configuration-specific photocatalytic degradation of methyl orange and methylene blue dyes using ZnO-based nanocomposites [0.03%]
基于ZnO的纳米复合材料在异质结构配置下对甲基橙和亚甲基蓝染料的光催化降解作用研究
Mengjiao Wu,Chengpu Lv,Yuling Xiong et al.
Mengjiao Wu et al.
Introduction: Heterostructured photocatalysts have shown an enormous potential in photocatalytic degradation of organic pollutants in wastewater. However, the efficacy of such heterojunction on the photocatalytic degradat...
Stattic engineering M2 macrophage-derived exosomes mediate autophagy and immune reprogramming for secondary hyperparathyroidism [0.03%]
工程化M2型巨噬细胞源性外泌体通过介导自噬和免疫重编程治疗继发性甲状旁腺功能亢进症
Peiting Li,Runzhi Liao,Jingyi Li et al.
Peiting Li et al.
Introduction: Secondary hyperparathyroidism (SHPT) remains a major complication of chronic kidney disease (CKD), characterized by parathyroid hyperplasia, inflammation, and parathyroid hormone (PTH) excessive secretion, a...
Preclinical evidence of adenosine for early intervention in Bungarus multicinctus envenomation [0.03%]
五步蛇毒液的临床前证据表明腺苷可作为早期干预手段
Jing Huang,Yue Qin,Haiyu Chen et al.
Jing Huang et al.
Introduction: Snakebites, one of the world's deadliest neglected tropical diseases, predominantly affect impoverished rural communities in tropical and subtropical regions. The clinical management of snakebite envenomatio...
Construction of mitochondrial-targeted ferritin carrier: subunit-terminal fused mitochondrial presequences facilitate efficient delivery [0.03%]
线粒体靶向铁蛋白载体的构建：亚基C末端融合线粒体导向序列促进有效递送
Jia Zeng,Yitong Li,Xinning Fang et al.
Jia Zeng et al.
Introduction: Protein sorting within mitochondria is intricately linked to the amino acid sequence facilitating the transmembrane transport of proteins into this organelle. Leveraging the Mitochondrial Targeting Signal (M...
Development and characterization of endolysosomal trafficking targeting chimera degraders of α1A-adrenergic receptor [0.03%]
靶向内溶酶体转运的嵌合降解剂的研发及α1A肾上腺素受体降解机制研究
Jiwei Chen,Shuo Wang,Tong Li et al.
Jiwei Chen et al.
Introduction: Despite the booming targeted protein degradation technologies, degrading cell membrane proteins remains an enormous challenge. In particular, only a limited approach is appropriate for the degradation of the...