Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS/CALR/Caspase-3/GSDME pathway [0.03%]
光活化诱导虎皮蓝激活ROS/CALR/ caspase-3/GSDME途径介导的三阴性乳腺癌细胞焦亡
Chen Liang,Xiao Liu,Jie Yu et al.
Chen Liang et al.
Introduction: Hypericin (HP), a natural photosensitizer, has demonstrated great efficacy in photodynamic therapy (PDT) for cancer treatment. In addition to the induction of apoptosis and necrosis through reactive oxygen s...
Integrative multi-omics analysis of autism spectrum disorder reveals unique microbial macromolecules interactions [0.03%]
自闭症谱系障碍的集成多组学分析揭示了独特的微生物大分子互作
Aya Osama,Ali Mostafa Anwar,Shahd Ezzeldin et al.
Aya Osama et al.
Introduction: Gut microbiota alterations have been implicated in Autism Spectrum Disorder (ASD), yet the mechanisms linking these changes to ASD pathophysiology remain unclear. ...
CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway [0.03%]
CHMP4C通过RIPK1/RIPK3/MLKL途径抑制坏死性凋亡从而促进胰腺癌进展
Longchen Yu,Qining Guo,Yaping Li et al.
Longchen Yu et al.
Introduction: Pancreatic cancer (PC) cannot currently be completely cured and has a poor prognosis. Necroptosis is a distinct form of regulated cell death that differs from both necrosis and apoptosis. Understanding the r...
Cardiac ATP production and contractility are favorably regulated by short-term S100A9 blockade after myocardial infarction [0.03%]
短期阻断心肌梗死后S100A9对心脏ATP生成和收缩功能的调节作用的影响
Raluca M Boteanu,Viorel I Suica,Elena Uyy et al.
Raluca M Boteanu et al.
Introduction: The infarcted heart is energetically compromised exhibiting a deficient production of adenosine triphosphate (ATP) and the ensuing impaired contractile function. Short-term blockade of the protein S100A9 imp...
FOXS1, frequently inactivated by promoter methylation, inhibited colorectal cancer cell growth by promoting TGFBI degradation through autophagy-lysosome pathway [0.03%]
FOXS1通过自噬-溶酶体途径促进TGFBI降解来抑制结直肠癌细胞的增殖，且其启动子区经常发生高甲基化失活
Yeye Kuang,Yijian Yu,Chan Wang et al.
Yeye Kuang et al.
Introduction: Tumor suppressor gene (TSG) inactivation by epigenetic modifications contributes to the carcinogenesis and progression of colorectal cancer (CRC). Expression profiling and CpG methylomics revealed that a for...
Ailanthone induces triple-negative breast cancer cells death involving the inhibition of OTUB1-mediated ERRα deubiquitylation [0.03%]
黄檀茋通过抑制OTUB1介导的ERRα去泛素化诱导三阴性乳腺癌细胞死亡
Ziyue Zhang,Wei Huang,Li Wang et al.
Ziyue Zhang et al.
Introduction: Triple-negative breast cancer (TNBC) remains the most aggressive subtype of breast cancer, and effective therapeutic strategies are needed. Estrogen-related receptor alpha (ERRα) is considered a promising t...
PIK3R3 regulates differentiation and senescence of periodontal ligament stem cells and mitigates age-related alveolar bone loss by modulating FOXO1 expression [0.03%]
PIK3R3通过调节FOXO1的表达来调控牙周韧带干细胞的分化和衰老并缓解年龄相关的牙槽骨丢失
Xuenan Liu,Donghao Wei,Feilong Wang et al.
Xuenan Liu et al.
Introduction: Periodontal diseases are prevalent among middle-aged and elderly individuals. There's still no satisfactory solution for tooth loss caused by periodontal diseases. Human periodontal ligament stem cells (hPDL...
Astragaloside IV ameliorates autism-like behaviors in BTBR mice by modulating Camk2n2-dependent OXPHOS and neurotransmission in the mPFC [0.03%]
绞股蓝皂苷IV通过调节Camk2n2依赖性OXPHOS和mPFC中的神经传递来改善BTBR小鼠自闭症样行为
Mei Chen,Jiahui Shi,Tianyao Liu et al.
Mei Chen et al.
Introduction: Autism spectrum disorder (ASD) represents a multifaceted set of neurodevelopmental conditions marked by social deficits and repetitive behaviors. Astragaloside IV (ASIV), a natural compound derived from the ...
Integrated multi-omics reveals the Bacillus amyloliquefaciens BA40 against Clostridium perfringens infection in weaned piglets [0.03%]
芽孢杆菌BA40通过整合多组学技术缓解仔猪感染产气荚膜梭菌所致的肠道损伤及屏障功能障碍
Zipeng Jiang,Weifa Su,Mingzhi Yang et al.
Zipeng Jiang et al.
Introduction: Clostridium perfringens (C. perfringens) can cause necrotic enteritis and higher mortality rates in piglets, by impairing the intestinal barrier function. Bacillus amyloliquefaciens 40 (BA40) has showed pote...
Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases [0.03%]
磷脂酶Cɛ1作为心血管疾病治疗靶点的研究
Jie Wang,Ting Gao,Dongmei Zhang et al.
Jie Wang et al.
Background: Phospholipase C epsilon 1 (PLCε1) can hydrolyze phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-4-phosphate at the plasma membrane and perinuclear membrane in the cardiovascular system, produci...