Lactational high weight loss impairs follicular development by causing mitochondrial dysfunction of ovarian cells in sows and mitigated by butyrate supplement [0.03%]
泌乳期母猪体重过快下降通过引起卵巢细胞线粒体功能障碍抑制卵泡发育，丁酸钠可缓解此效应
Kexiong Liu,Luyao Zhang,Xiaoling Xu et al.
Kexiong Liu et al.
Introduction: In modern sows, lactational high weight loss (HWL), caused by the large litter size and inadequate feed intake, has a negative effect on follicular development after weaning, resulting in poor reproductive p...
Targeted regulation of sterol biosynthesis genes according to perturbations in ergosterol biosynthesis in fungi [0.03%]
根据真菌麦角固醇生物合成中的扰动靶向调节甾醇生物合成基因
Pengju Yu,Mi Zhou,Deshui Yu et al.
Pengju Yu et al.
Introduction: The synthesis and regulation of ergosterol are vital for fungal growth and stress adaptation. While ergosterol-mediated feedback regulation is a recognized mechanism controlling sterol biosynthesis in fungi,...
Detection of Staphylococcus aureus via IgY-Based immunomagnetic separation and a phage lysin LysGH15-Based colloidal gold immunochromatographic assay [0.03%]
基于IgY的免疫磁分离和LysGH15胶体金免疫层析试纸条联用检测金黄色葡萄球菌
Xiao Liu,Zhimin Guo,Yinghan Qiao et al.
Xiao Liu et al.
Introduction: Staphylococcus aureus (S. aureus) is an important human pathogen that frequently causes disease in hospital and community settings. Due to the pervasive emergence of virulent and multidrug-resistant methicil...
Elucidation of the biosynthetic pathways of timosaponins reveals the antifungal mechanisms in Anemarrhena asphodeloides [0.03%]
天门冬甾体皂苷的生物合成途径解析及其抗真菌机制研究
Baolian Fan,Zhongju Ji,Min Zhu et al.
Baolian Fan et al.
Introduction: Timosaponins, as steroidal saponins, are the primary active constituents and quality biomarkers in Anemarrhena asphodeloides Bunge. Despite their significance, the biosynthetic pathways of timosaponins have ...
Xueliang Peng,Xuanning Chen,Yifan Zhang et al.
Xueliang Peng et al.
Background: Osteoarthritis (OA), a widespread degenerative joint disease, predominantly affects individuals from middle age onwards, exhibiting non-inflammatory characteristics. OA leads to the gradual deterioration of ar...
Sp3 ameliorated experimental autoimmune encephalomyelitis by triggering Socs3 in Th17 cells [0.03%]
Sp3通过激活Th17细胞中的Socs3改善自身免疫性脑脊髓炎
Yan Li,Mengyi Zhu,Penghui Yang et al.
Yan Li et al.
Introduction: Although it is believed that chronic inflammatory and degenerative diseases of the central nervous system are mediated by autoimmune Th17 cells, the underlying mechanisms remain largely unexplored. Recent st...
Zn-doped CaP coating equips Ti implants with corrosion resistance, biomineralization, antibacterial and immunotolerant activities [0.03%]
掺锌CaP涂层使钛植入物具备耐蚀、生物矿化、抗菌和免疫调控性能
Anca C Parau,Senem Büyüksungur,Guanhao Li et al.
Anca C Parau et al.
Introduction: Chronic inflammation leading to implant failure present major challenges in orthopedics, dentistry, and reconstructive surgery. Titanium alloys, while widely used, often provoke inflammatory complications. Z...
Autophagy activation within inflammatory microenvironment improved the therapeutic effect of MSC-Derived extracellular Vesicle in SLE [0.03%]
炎症微环境中自噬激活可增强间充质干细胞来源的外泌体治疗SLE效果
Shuzhen Liao,Fengbiao Guo,Zengzhi Xiao et al.
Shuzhen Liao et al.
Introduction: Developing strategies to improve the therapeutic efficacy of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in autoimmune diseases have garnered increased attention. ...
Actl6a regulates autophagy via Sox2-dependent Atg5 and Atg7 expression to inhibit apoptosis in spinal cord injury [0.03%]
ACTL6A通过Sox2依赖性Atg5和Atg7表达调节自噬抑制脊髓损伤中的细胞凋亡
Jian Hao,Yubiao Yang,Li Xie et al.
Jian Hao et al.
Introduction: Spinal cord injury (SCI) is a severe central nervous system disorder with limited treatment options. While autophagy plays a protective role in neural repair, its regulatory mechanisms in SCI remain unclear....
The urinary eccDNA landscape in prostate cancer reveals associations with genome instability and vital roles in cancer progression [0.03%]
前列腺癌尿液eccDNA景观揭示其与基因组不稳定的相关性及其在癌症进展中的重要作用
Shengcai Chen,Zhimin Zhou,Yangchen Ye et al.
Shengcai Chen et al.
Introduction: Extrachromosomal circular DNA (eccDNA) plays significant roles in cancer progression and prognosis. However, it remains unclear whether cell-free eccDNA, considered more stable than linear DNA, possesses can...