Machine learning ensemble meets clinical practice: developing a real-world risk prediction model for metabolic syndrome using super learner and scorecard approaches [0.03%]
机器学习集成与临床实践相结合：使用超级学习器和评分卡方法开发代谢综合征的现实风险预测模型
Shuwen Li,Yu Zhang,Kang Fu et al.
Shuwen Li et al.
Introduction: Metabolic syndrome (MetS) refers to a cluster of metabolic abnormalities that significantly increase the risk of developing cardiovascular diseases (CVDs). Traditional binary definitions of MetS fall short i...
Aryl hydrocarbon receptor, a promising therapeutic target for ulcerative colitis, impairs HK2-controlled flux of hexosamine-biosynthesis pathway to eliminate NETosis in an N-glycosylation dependent manner [0.03%]
芳烃受体通过N-糖基化依赖的方式损害HK2控制的半乳糖胺生物合成途径通量以消除NETosis，有望成为治疗溃疡性结肠炎的新靶点
Shijia Li,Jingchao Zhu,Jie Song et al.
Shijia Li et al.
Introduction: The aryl hydrocarbon receptor (AhR) is a promising therapeutic target for ulcerative colitis (UC) and plays a role in regulating neutrophil function. ...
Enhancing NOx emission control and energy efficiency of H2/NH3 powered micro generator in a planar porous combustor [0.03%]
一种平面多孔燃烧器中H2/NH3驱动的微电站NOx减排及能效提升方法研究
Hao Wang,Qingguo Peng,Zhixin Huang et al.
Hao Wang et al.
Introduction: Micro-thermoelectric system fueled by hydrocarbon with the simple construction, no moving parts and high energy density, have garnered extensive attention. However, micro combustors are facing challenges of ...
Designing an apoptosis reporter by mutagenesis-based insertion of caspase-3 cleavage motif into green fluorescence protein [0.03%]
基于突变的插入半胱天冬酶-3切割基序到绿色荧光蛋白中的凋亡报告的设计
Dong Gil Lee,Hae-Jun Yang,Unbin Chae et al.
Dong Gil Lee et al.
Introduction: Apoptosis is an essential process for organisms and animal development, and its dysregulation is related to the progression of several diseases. Therefore, methods to detect apoptosis are necessary for mecha...
Pharmacokinetic Modelling During Long-Term Anesthesia: Minimizing the Gap [0.03%]
长期麻醉中的药代动力学模型：缩小差距
Amani R Ynineb,Erhan Yumuk,Dana Copot et al.
Amani R Ynineb et al.
Introduction: Surgical procedures exceeding six hours and intensive care for traumatic injuries often require prolonged general anesthesia, commonly maintained via induced coma. Similar protocols are used for COVID-19 pat...
Targeting intracellular mRNA m6A-modifiers in advancing immunotherapeutics [0.03%]
靶向胞内mRNA m6A修饰酶以推进免疫治疗研究进展
Sunil Kumar,Mithun Sinha
Sunil Kumar
An impressive clinical success has been achieved in the treatment of various cancers employing immunotherapy and checkpoint blockade antibodies. However, limited therapeutic response has been observed in most of the patients receiving anti-...
Melanin nanoparticles-loaded lactobacillus fermentum exosomes for targeted and visualized treatment of ulcerative colitis [0.03%]
负载黑色素纳米粒的乳酸菌发酵滤泡 exosome 用于可视化治疗溃疡性结肠炎
Caifang Gao,Wenjing Zhao,Ru Feng et al.
Caifang Gao et al.
Introduction: Ulcerative colitis (UC) is chronic specific intestinal inflammation characterized by excessive reactive oxygen species, augmented inflammation, imbalanced microbiota and aberrant immune environment. However,...
Engineering polyphenol-based osteogenic system for bone and cartilage repair: Transplantation, tissue engineering, and organoid [0.03%]
基于棓酸酯的骨诱导系统的移植、组织工程及类器官研究
Qiuting Wang,Min Mu,Wei Yu et al.
Qiuting Wang et al.
Background: The human body can spontaneously repair damaged bone tissue and cells; however, external interventions are required to support bone regeneration when the defect exceeds a critical threshold. Bone repair primar...
Therapeutic role of caveolin family in stem cell fate and development for management of chronic degenerative diseases: A scientometric study to an in-depth review [0.03%]
cavesolulin家族在干细胞命运和发育中的治疗作用以及其在慢性退行性疾病管理中的应用：科学计量研究与深入综述
Ruishuang Ma,Shuang Wang,Yuan-Lu Cui et al.
Ruishuang Ma et al.
Background: Caveolins (CAV), a family of integral membrane proteins, are involved in regulating stem cell fate, which are critical for tissue repair and regeneration. Drawing from scientometric studies and comprehensive r...
Perfluorooctane sulfonic acid impairs spermatogenesis via the liver-gut microbiota-testis axis: a central role of chenodeoxycholic acid metabolism [0.03%]
全氟辛烷磺酸通过肝-肠菌群-睾丸轴损伤生精作用：胆石酸代谢途径起关键作用
Wang Yang,Peng Zou,Shijun He et al.
Wang Yang et al.
Introduction: Perfluorooctane sulfonic acid (PFOS) as a global contaminant is ubiquitously presented in the environmental media and human body. The association between PFOS exposure and reduced male fertility has been rec...