Discovery of FBP1 as novel therapeutic target and asiatic acid-hydrogen sulfide donors accelerate diabetic wound healing [0.03%]
FBP1被发现是新的治疗靶点及总冠字第ⅹ号巴西酸-氢 sulfide供体可加速糖尿病伤口愈合
Shenglin Wang,Tongtong Ye,Lihao Shi et al.
Shenglin Wang et al.
Introduction: Wound healing impairment is highly prevalent in diabetes and frequently progresses to serious complications, including refractory ulcers and necessitated amputations. RNA sequencing in methylglyoxal (MGO)-in...
c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis c-Myc-PANK3-EMT axis regulates UC intestinal barrier integrity [0.03%]
c-Myc-PANK3-EMT轴调控溃疡性结肠炎肠道屏障结构和功能
Shize Zhang,Yuang Chen,Nan Aa et al.
Shize Zhang et al.
Introduction: The repair of structural damage of the intestinal barrier is critical to rescue ulcerative colitis (UC), but there lacks effective targets currently. ...
Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation [0.03%]
丁苯酞通过调节波形蛋白重构脑血管单元促进缺血性卒中后神经功能恢复
Haiyan Xiao,Haochen Xie,Meng Qin et al.
Haiyan Xiao et al.
Introduction: Ischemic stroke severely threatens human health. Rapid restoration of cerebral blood flow (CBF) in ischemic microvessels is significant as it enhances neurovascular function, prevents neuronal death, and min...
Aromatic short peptide-metal nanoassemblies in smart hydrogel sensors for real-time food freshness monitoring [0.03%]
用于实时监控食品新鲜度的智能水凝胶传感器中的芳香短肽-金属纳米组件
Xuecheng Zhu,Jing Su,Yuzhen Wang et al.
Xuecheng Zhu et al.
Introduction: The accumulation of volatile biogenic amines (BAs) during food spoilage constitutes a global economic and public health burden. Conventional BA detection methods based on chromatography and electrochemistry ...
Modulation of the tumor microenvironment through BMAL1-LHX8 axis augments the sensitivity of ameloblastoma to vemurafenib [0.03%]
通过BMAL1-LHX8轴调节肿瘤微环境可增强成釉细胞瘤对维莫非尼的敏感性
Shujin Li,Eun-Jung Kim,Hyun-Yi Kim et al.
Shujin Li et al.
Introduction: Ameloblastoma (AM) frequently develops resistance to the BRAF inhibitor vemurafenib, primarily mediated by ameloblastoma-associated fibroblasts (AMFs). However, the potential contribution of the circadian cl...
Unique molecular architecture of N-glycosylated TM4SF5 dimer highlights evolutionary and structural divergence among small four-transmembrane protein families [0.03%]
N-糖基化TM4SF5二聚体的独特分子结构凸显了小四次跨膜蛋白家族的进化和结构差异
Yoonji Lee,Ji Eon Kim,Wonsik Kim et al.
Yoonji Lee et al.
Introduction: Membrane proteins, including small four-transmembrane proteins, play roles in membrane organization and signal transduction. Generally, they share capacities for protein-protein association and subcellular t...
From waste to resource: development of selenium-enhanced iron-carbon galvanic materials from landfill leachate for efficient mercury and thallium detoxification in contaminated waters [0.03%]
从垃圾渗滤液中开发硒增强型铁碳电化学材料用于污染水体的高效除汞和铊毒害化研究
Dongping Song,Tao Huang,Jialin Cui et al.
Dongping Song et al.
Landfill leachate, characterized by high concentrations of organic pollutants, ammonia nitrogen (NH3-N), and heavy metals (HMs), impacts ecosystems and human health threats. Conventional treatment technologies exhibit significant efficiency...
Pericyte-myofibroblast transition: a novel mechanism in peritoneal fibrosis and the effect of Asiaticoside [0.03%]
球周细胞肌成纤维细胞转化：腹膜纤维化中的一种新机制及 asiaticoside 的影响
Jun Shi,Lei Tang,Manshu Yu et al.
Jun Shi et al.
Introduction: Peritoneal fibrosis (PF), a major complication of long-term peritoneal dialysis (PD), is characterized by excessive extracellular matrix (ECM) deposition mediated by activated myofibroblasts (MyoFs). While m...
Intratumoral microbiota in colorectal cancer: roles, therapeutic potential, and challenges [0.03%]
结直肠癌瘤内微生物群：作用、治疗潜力和挑战
Xiyu Zhang,Junwen Qi,Chenhua Dong et al.
Xiyu Zhang et al.
Background: Colorectal cancer (CRC) is a multifactorial disease characterized by disruptions in cellular and immune functions, influenced by genetic mutations, environmental factors, and infections. Recent studies have hi...
Paracrine iron activates Hopx+ rectal cancer stem cells to display radioresistance [0.03%]
旁分泌铁激活Hopx+直肠癌干细胞并产生放射耐药性
Xiangjun Liu,Xudan Lei,Jianhua Feng et al.
Xiangjun Liu et al.
Background & aims: The quiescence-activation transition of cancer stem cells regulated by environmental stimuli has been shown to potentially contribute to cancer maintenance and regrowth after therapy. However, little is...