Toward animal-free cardiac safety testing: Early detection of cardiotoxic reactions via multimodal in vitro readouts [0.03%]
无动物心脏安全检测研究进展：通过体外多模式读数早期发现心脏毒性反应
Na Kyeong Park,Jaewoo Park,Yun-Gwi Park et al.
Na Kyeong Park et al.
Introduction: As regulatory agencies such as the FDA move toward phasing out animal testing in preclinical studies, there is a growing demand for human-relevant, cell-based models for cardiac safety assessment. Human indu...
Conditional deletion of MDM2 in neurons impairs neuronal homeostasis and cognitive ability [0.03%]
神经元中的条件性删除MDM2会损害神经元稳态和认知能力
Ying Jin,Hengzhen Cui,Junya Kang et al.
Ying Jin et al.
Introduction: Murine double minute 2 (MDM2) has been implicated in diverse neurological disorders, yet its precise function in the central nervous system remains poorly defined. ...
Engineered natural extracellular matrix platform for modelling skin diseases and therapeutic targets discovery [0.03%]
用于皮肤疾病建模和治疗靶点发现的工程化天然细胞外基质平台
M D Malta,M G Fernandes,L Martins et al.
M D Malta et al.
Introduction: Dysregulation of the dermal extracellular matrix (ECM) drives skin pathologies by influencing tissue mechanics, dermal-epidermal adhesion, and disease progression. However, current in vitro models often fail...
BMI1 activated by ZBTB17 stabilizes SMAD2 to promote chondrocyte anabolism and alleviate osteoarthritis [0.03%]
由ZBTB17激活的BMI1通过稳定SMAD2促进软骨细胞合成代谢和缓解骨关节炎
Xiao-Fei Zhang,Bo-Wen Zhang,Fan Wu et al.
Xiao-Fei Zhang et al.
Introduction: Osteoarthritis (OA) is the most prevalent degenerative joint disorder worldwide, characterized by impaired anabolic activity and excessive catabolic responses in chondrocytes. However, the precise mechanisms...
Artificial intelligence-driven early screening and diagnosis of pancreatic cancer: technical innovations, clinical applications, and precision medicine strategies [0.03%]
人工智能驱动的胰腺癌早期筛查与诊断：技术革新、临床应用及精准医疗策略
Yan-Rong Li,Dan Li,Yi-Wei Zhou et al.
Yan-Rong Li et al.
Background: Pancreatic cancer is characterized by prolonged subclinical progression, molecular heterogeneity, and late clinical presentation, resulting in diagnosis predominantly at advanced stages. Current screening appr...
Lipoprotein lipase facilitates Aβ transport across the blood-brain barrier via LRP1: Validation of the obesity paradox in Alzheimer's disease [0.03%]
脂蛋白脂肪酶通过LRP1促进Aβ透过血脑屏障：验证阿尔茨海默病中的肥胖悖论
Na Meng,Cui Li,Fusheng Bai et al.
Na Meng et al.
Introductions: Being obese in mid-life is an increased risk of dementia and cognitive decline in late-life, while being obese in late-life is shown to be associated with a lower risk of these outcomes in some studies, whi...
Maxillary palp odorant-binding proteins as key mediators of bitter taste and molecular targets for cockroach control [0.03%]
大颚嗅觉结合蛋白作为蟑螂苦味感觉的关键介质和防治靶标
Hong-Yan Feng,Ya-Qin Zhao,Tao-Yang et al.
Hong-Yan Feng et al.
Introduction: The German cockroach (Blattella germanica) is a notorious urban pest with significant health impacts, owing in part to its highly sophisticated gustatory system that enables precise food discrimination and t...
UDP-glycosyltransferase-mediated adaptation to mulberry flavonoids enhances silkworm detoxification and antioxidant capacity [0.03%]
参与桑树天然茋类化合物代谢的家蚕UDPGT基因的分子进化及功能分析
Hulin Lu,Jiubo Liang,Peirong Qin et al.
Hulin Lu et al.
Introduction: Uridine diphosphate (UDP) glycosyltransferases (UGTs) are a major class of detoxifying enzymes that metabolize xenobiotics through glycosylation. Although UGTs are widely implicated in insect resistance to p...
Rutin Combats Salmonella infection through virulence suppression and gut barrier maintenance [0.03%]
rutin通过抑制毒力和维持肠道屏障来抵抗沙门氏菌感染
Tao Wang,Xinyou Zhang,Haihua Feng et al.
Tao Wang et al.
Introduction: Salmonella Typhimurium (S. Typhimurium) is a major zoonotic pathogen causing severe gastroenteritis and septicemia. Traditional antibiotics targeting bacterial growth face increasing resistance challenges, w...
Chac1 deficiency confers sepsis resistance by enriching gut microbiota-derived indole-3-carboxylic acid to drive macrophage metabolic shifts [0.03%]
CHAT1缺乏通过丰富肠道菌群来源的吲哚-3-羧酸来驱动巨噬细胞代谢转变从而增强对败血症的抵抗力
Jing-Juan Hu,Si-Yuan Feng,Ling Wu et al.
Jing-Juan Hu et al.
Introduction: Sepsis is a life-threatening dysregulated host response to infection, lacks effective therapies. ChaC glutathione-specific γ-glutamylcyclotransferase 1 (CHAC1) is elevated in sepsis and correlates with seve...