Cellular and molecular mechanisms of nasolacrimal duct obstruction: New insights into CD4+ T cell-MIF-fibroblast pathways [0.03%]
鼻泪管阻塞的细胞和分子机制：CD4⁺T细胞-MIF-成纤维细胞途径的新见解
Xinyue Yu,Shanshan Liu,Youao Zhang et al.
Xinyue Yu et al.
Introduction: Nasolacrimal duct obstruction (NLDO) is a common ophthalmic condition characterized by epiphora and ocular discharge. Its etiology remains poorly understood, and treatment primarily relies on surgical interv...
Comparative genomics reveals two major lineages of Bifidobacterium adolescentis in the human gut, driven by divergent adaptation in China and the United States [0.03%]
比较基因组学揭示了人类肠道中青春双歧杆菌的两大谱系：在中国和美国适应性分化驱动下
Linbo Shi,Meng Zhang,Ruonan Zheng et al.
Linbo Shi et al.
Introduction: Bifidobacterium adolescentis is a key beneficial member of the human gut microbiota, but its genomic diversity and evolutionary drivers across human populations remain poorly characterized. ...
Molecular choreography of vesicle trafficking: Exocyst-SNARE interplay in plant defense [0.03%]
囊泡转运的分子演绎：植物防御中的exocyst-snare相互作用
Muhammad Adnan,Liu Xiaokun
Muhammad Adnan
Background: The plant secretory system operates as a precision logistics network that sustains cellular homeostasis and mobilizes rapid defense against pathogens. Central to this system are SNARE (soluble N-ethylmaleimide...
High-protein diet promotes aging by activating the CG6415/AMT gene and disrupting mitochondrial homeostasis [0.03%]
高蛋白饮食通过激活CG6415/AMT基因和破坏线粒体稳态而促进衰老
Xiaoqing Xu,Yang Wang,Qianmin Liu et al.
Xiaoqing Xu et al.
Introduction: Dietary protein has multiple physiological functions. However, high-protein diets have been proven to elevate the risk of all-cause mortality. Aging is a dynamic and complex process, but the impact of dietar...
Selectively targeting UDP-glucose 4-epimerase MoUGE1 for controlling rice blast disease [0.03%]
选择性靶向UDP葡萄糖4差向异构酶MoUGE1以控制水稻稻瘟病
Zhiguang Qu,Deng Chen,Hong Hu et al.
Zhiguang Qu et al.
Introduction: The fungal cell wall, a dynamic structure critical for pathogenesis, is composed of polysaccharides and proteins. UDP-glucose 4-epimerases (UGEs) play a pivotal role in cell wall synthesis by converting UDP-...
Mitocytosis, mitophagy, and apoptosis coordinately drive mitochondrial clearance to regulate myogenic differentiation [0.03%]
线粒体自噬、线粒体胞吐和凋亡在调节肌细胞分化过程中的协同作用
Dandan Wang,Mei Li,Jun Ma et al.
Dandan Wang et al.
Introduction: Skeletal muscle is a high-energy-consuming tissue whose development and function critically depend on mitochondrial homeostasis. Mitochondrial quality control involves multiple clearance mechanisms, includin...
OSBPL6 protects against demyelination and behavioral disorder via promoting cholesterol transport in oligodendrocyte [0.03%]
OSBPL6通过促进少突胶质细胞胆固醇运输来抵抗脱髓鞘和行为异常
Mengni Chang,Kaiqi Zhang,Ye Li et al.
Mengni Chang et al.
Introduction: Demyelination is associated with behavioral disorder and cognitive impairment in neuropsychiatric diseases, including major depressive disorder (MDD). However, the mechanism underlying myelin damage remains ...
A novel extracellular vesicle-engineered immunotherapy drug for Her2+ breast cancer [0.03%]
一种新型的工程化细胞外囊泡免疫治疗药物用于Her2阳性乳腺癌
Xinliang Lu,Weiyi Yuan,Xianchang Zeng et al.
Xinliang Lu et al.
Trastuzumab profoundly improves outcomes of Her2+ breast cancer (BC) patients, but eventual drug resistance is inevitable. Therefore, new treatment options are urgently needed. Here, we modify extracellular vesicles (EVs) with a Her2 single...
A plant virus-derived siRNA modulates wing dimorphism and fertility of vector insects to enhance virus spread [0.03%]
一种植物病毒衍生的siRNA能够调节载体昆虫的翅二形性和育性以促进病毒传播
Yiming Wang,Qiao Gao,Lian Shan et al.
Yiming Wang et al.
Introduction: The infection of plant viruses alters the wing dimorphism and reproductive development of vector insects, thereby enhancing viral dissemination. Notably, a fundamental trade-off inherently exists between win...
Targeted delivery of senolytic drugs using macrophage membrane-camouflaged magnetic nanoparticles inhibits endplate sclerosis [0.03%]
利用巨噬细胞膜伪装的磁性纳米颗粒靶向递送抗衰老药物可抑制终板软骨硬化现象
Weiping Su,Chenhao Shi,Yixiao Pan et al.
Weiping Su et al.
Introduction: Low back pain (LBP) is a prevalent cause of disability worldwide. A crucial mechanism underlying LBP is that senescent-like macrophages induce endplate sclerosis by coupling angiogenesis-osteogenesis through...