Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury [0.03%]
综合单细胞分析阐明了TPPU在缓解脓毒症相关急性肝损伤中的免疫调节机制
Juan Li,Mengjuan Xuan,Li Yang et al.
Juan Li et al.
Introduction: Sepsis-related acute liver injury involves complex immune dysfunctions. Epoxyeicosatrienoic acids (EETs), bioactive molecules derived from arachidonic acid (AA) via cytochrome P450 (CYP450) and rapidly hydro...
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function [0.03%]
新型的蚝源肽-锌复合物的双重吸收路径提高了锌的生物利用度并恢复了线粒体功能
Ximing Yang,Siyi Wang,Hanxiong Liu et al.
Ximing Yang et al.
Zinc deficiency is a global health issue that impairs immune function, growth, and energy metabolism. Although conventional zinc supplements have been developed, their effectiveness is limited by poor bioavailability and susceptibility to d...
Mebendazole induces ZBP-1 mediated PANoptosis of acute myeloid leukemia cells by targeting TUBA1A and exerts antileukemia effect [0.03%]
甲苯达唑通过靶向TUBA1A诱导急性髓性白血病细胞发生ZBP-1介导的PANoptosis并发挥抗白血病作用
Wei Yang,Ying Xu,Shuai Liu et al.
Wei Yang et al.
Background: Despite notable advancements in AML therapy in recent years, a substantial proportion of patients remain refractory or at high risk of recurrence with limited efficacy. Therefore, it's urgent to develop novel ...
Blocking S1P4 signaling attenuates brain injury in mice with ischemic stroke [0.03%]
阻断S1P4信号可减轻缺血性卒中小鼠的脑损伤
Nikita Basnet,Hyunkyung Cho,Arjun Sapkota et al.
Nikita Basnet et al.
Introduction: The functions of S1P receptors have been revealed using genetic and pharmacological tools, including the potent non-selective modulator FTY720. However, studies on subtype-specific agonists and antagonists a...
Ai-enabled language models (LMs) to large language models (LLMs) and multimodal large language models (MLLMs) in drug discovery and development [0.03%]
人工智能赋能的语言模型（LMs）在药物发现与开发中的应用：从大型语言模型（LLMs）到多模态大型语言模型（MLLMs）
Chiranjib Chakraborty,Manojit Bhattacharya,Soumen Pal et al.
Chiranjib Chakraborty et al.
Background: Due to the recent revolution of artificial intelligence (AI), AI-enabled large language models (LLMs) have flourished and started to be applied in various sectors of science and medicine. Drug discovery and de...
Sequential allogeneic HSCT after CAR-T therapy for relapsed/refractory acute lymphoblastic leukemia patients: A long-term follow-up result [0.03%]
CAR-T治疗后复发/难治急性淋巴细胞白血病患者的序贯异基因HSCT：一项长期随访结果
Tingting Yang,Yetian Dong,Jimin Shi et al.
Tingting Yang et al.
Introduction: CAR-T cell therapy has revolutionized the therapeutic landscape for relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL), and bridging with allogeneic hematopoietic stem cell transplantation...
Acetate prevents pistil dysfunction in rice under heat stress by inducing methyl jasmonate and quercetin synthesis [0.03%]
乙酸通过诱导甲基茉莉酸和芹菜素的合成来防止高温胁迫下水稻雌蕊功能失调
Hubo Li,Yongqiang Xu,Jie Lin et al.
Hubo Li et al.
Introduction: Acetic acid (HAC) is a crucial signal molecule in plant stress responses; however, its role in conferring heat tolerance to rice remains unclear. ...
Development of dual disease resistant Basmati rice varieties offer significant economic advantage and impetus to sustainable crop production [0.03%]
双病抗性巴斯马蒂稻米品种的开发为可持续作物生产提供了显著的经济优势和动力
Ranjith Kumar Ellur,Apurva Khanna,Ashutosh Kumar Yadav et al.
Ranjith Kumar Ellur et al.
Introduction: Bacterial blight and blast are the major diseases causing production losses to an extent of 31.52% to 67.79%, respectively. Use of chemical pesticides leads to increased cost of cultivation, degradation of e...
Synthetic tunable promoters for flexible control of multi-gene expression in mammalian cells [0.03%]
合成可调式启动子在哺乳动物细胞多重基因表达中的灵活调控作用
Zong-Heng Fu,Si Cheng,Jia-Wei Li et al.
Zong-Heng Fu et al.
Introduction: Synthetic biology revolutionizes our ability to decode and recode genetic systems. The capability to reconstruct and flexibly manipulate multi-gene systems is critical for understanding cellular behaviors an...
Qian Sun,Hua Chang,Huan Wang et al.
Qian Sun et al.
Background: Extracellular vesicles (EVs) are heterogeneous membranous structures released by various cell types, including large vesicles, microvesicles (MVs), and exosomes. These vesicles play crucial roles in intercellu...