Pharmacokinetic Modelling During Long-Term Anesthesia: Minimizing the Gap [0.03%]
长期麻醉中的药代动力学模型：缩小差距
Amani R Ynineb,Erhan Yumuk,Dana Copot et al.
Amani R Ynineb et al.
Introduction: Surgical procedures exceeding six hours and intensive care for traumatic injuries often require prolonged general anesthesia, commonly maintained via induced coma. Similar protocols are used for COVID-19 pat...
Targeting intracellular mRNA m6A-modifiers in advancing immunotherapeutics [0.03%]
靶向胞内mRNA m6A修饰酶以推进免疫治疗研究进展
Sunil Kumar,Mithun Sinha
Sunil Kumar
An impressive clinical success has been achieved in the treatment of various cancers employing immunotherapy and checkpoint blockade antibodies. However, limited therapeutic response has been observed in most of the patients receiving anti-...
Melanin nanoparticles-loaded lactobacillus fermentum exosomes for targeted and visualized treatment of ulcerative colitis [0.03%]
负载黑色素纳米粒的乳酸菌发酵滤泡 exosome 用于可视化治疗溃疡性结肠炎
Caifang Gao,Wenjing Zhao,Ru Feng et al.
Caifang Gao et al.
Introduction: Ulcerative colitis (UC) is chronic specific intestinal inflammation characterized by excessive reactive oxygen species, augmented inflammation, imbalanced microbiota and aberrant immune environment. However,...
Engineering polyphenol-based osteogenic system for bone and cartilage repair: Transplantation, tissue engineering, and organoid [0.03%]
基于棓酸酯的骨诱导系统的移植、组织工程及类器官研究
Qiuting Wang,Min Mu,Wei Yu et al.
Qiuting Wang et al.
Background: The human body can spontaneously repair damaged bone tissue and cells; however, external interventions are required to support bone regeneration when the defect exceeds a critical threshold. Bone repair primar...
Therapeutic role of caveolin family in stem cell fate and development for management of chronic degenerative diseases: A scientometric study to an in-depth review [0.03%]
cavesolulin家族在干细胞命运和发育中的治疗作用以及其在慢性退行性疾病管理中的应用：科学计量研究与深入综述
Ruishuang Ma,Shuang Wang,Yuan-Lu Cui et al.
Ruishuang Ma et al.
Background: Caveolins (CAV), a family of integral membrane proteins, are involved in regulating stem cell fate, which are critical for tissue repair and regeneration. Drawing from scientometric studies and comprehensive r...
Perfluorooctane sulfonic acid impairs spermatogenesis via the liver-gut microbiota-testis axis: a central role of chenodeoxycholic acid metabolism [0.03%]
全氟辛烷磺酸通过肝-肠菌群-睾丸轴损伤生精作用：胆石酸代谢途径起关键作用
Wang Yang,Peng Zou,Shijun He et al.
Wang Yang et al.
Introduction: Perfluorooctane sulfonic acid (PFOS) as a global contaminant is ubiquitously presented in the environmental media and human body. The association between PFOS exposure and reduced male fertility has been rec...
The novel synbiotic (Lactiplantibacillus plantarum and galacto-oligosaccharides) ameliorates obesity-related metabolic dysfunction: Arginine as a key mediator signaling molecule [0.03%]
新型益生元协同组合（植物乳杆菌和半乳糖低聚糖）改善肥胖相关代谢紊乱：精氨酸作为关键信号分子介导上述作用
Renjie Shi,Jiangpeng Wei,Jin Ye et al.
Renjie Shi et al.
Objective: This study aimed to develop a novel synbiotic composed of Lactiplantibacillus plantarum LLY-606 and galacto-oligosaccharides (GOS) to improve lipid metabolism in obesity. Design Through genome-wide analysis usi...
Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relation between physical frailty and neuropsychiatric disorders [0.03%]
遗传机制、脑结构和周围生物标志物介导了身体脆弱性和神经精神障碍之间的关系
Pei-Yang Gao,Yan Fu,Xiao-Yu He et al.
Pei-Yang Gao et al.
Introduction: Physical frailty, which is characterized by multisystem functional decline, has emerged as a significant risk factor for adverse health outcomes. However, the relationship among physical frailty, brain funct...
Optimized stereoelectroencephalography-guided thermocoagulation versus anterior temporal lobectomy in mesial temporal epilepsy: A pilot randomized controlled study [0.03%]
优化的立体脑电图引导下热凝术与颞叶前侧切除术治疗内侧颞叶癫痫的疗效对比：一项随机对照研究
Yongzhi Shan,Jianwei Shi,Tianren Wang et al.
Yongzhi Shan et al.
Introduction: Anterior temporal lobectomy (ATL) is the standard surgical treatment for drug-resistant mesial temporal lobe epilepsy (MTLE); however, it is associated with cognitive decline and visual field deficits. In th...
Nan Li,Jianpeng Zhuang,Jiayi Wu et al.
Nan Li et al.
Introduction: To cope with the host's stressful environment and immune clearance, some drug-resistant bacteria have reduced their virulence. Protein post-translational modifications (PTMs) are known to regulate numerous c...