Transcriptomic and metabolomic profiles reveal the functions of IGF1 c.258 A > G synonymous mutation in milk fat content [0.03%]
转录组和代谢组轮廓揭示IGF1同义突变c.258A>G影响牛奶脂肪含量的机制
Jiayuan Fang,Shuo Zheng,Xunming Zhang et al.
Jiayuan Fang et al.
Introduction: Previous studies have reported that IGF-1 single nucleotide polymorphism is associated with milk fat traits, but they are limited to trait association analysis. We previously identified a synonymous mutation...
Soil moisture and ecosystem vegetation health effects on drought severity [0.03%]
土壤水分和生态系统植被健康对干旱强度的影响
Muhammad Abrar Faiz,Liangliang Zhang,Dong Liu et al.
Muhammad Abrar Faiz et al.
Introduction: Droughts are expected to become more severe due to climate disturbances, posing a serious risk to ecosystems. Therefore, quantifying the drought severity and the resilience of soil moisture and vegetation gr...
Warming-induced unstable microbial community metabolically lowers straw-carbon sequestration in paddy soils [0.03%]
增温诱导的微生物群落不稳定降低了水稻土对秸秆碳封存的能力
Jinyuan Zhang,Zhenhua Yu,Yi Gao et al.
Jinyuan Zhang et al.
Introduction: Growing academic attention has been given to the crucial role of soil microorganisms in the net loss of soil organic carbon (SOC) under climate warming and the effectiveness of straw-C sequestration to reple...
The IL-1β/NETs/AIM2 axis participates in the formation of trauma-induced heterotopic ossification by orchestrating crosstalk between neutrophils and macrophages [0.03%]
IL-1β/NETs/AIM2轴通过协调中性粒细胞和巨噬细胞之间的相互作用参与创伤后异位骨的形成
Zhengqiang Yuan,Siyuan Yao,Xiangyun Yao et al.
Zhengqiang Yuan et al.
Introduction: The limitations of clinical treatment for trauma-induced heterotopic ossification (tHO) make it of great significance to fully study its pathogenesis for the treatment of this disease. The infiltration of in...
CCR1hi/CCL5hi macrophage-mediated CCL5hi T cell chemotaxis in salivary gland aggravates Sjögren's syndrome [0.03%]
唾液腺中CCR1hi/CCL5hi单核吞噬细胞介导的CCL5hi T细胞趋化作用会加重舍格伦综合征
Jiannan Zhou,Yingyi Huang,Di Xiao et al.
Jiannan Zhou et al.
Introduction: CCR1 upregulation in macrophages promotes sequential T/B-cell infiltration via CCL5-mediated crosstalk, aggravating salivary gland damage in Sjögren's syndrome (SS), implicating CCR1/CCL5 as potential thera...
Intestinal microplastic debris, flora dysbiosis, and insidious combined hazards across diverse aquatic and terrestrial organisms [0.03%]
肠道微塑料碎片、菌群失调及跨多种水生和陆地生物的潜在复合危害
Tiantian Gao,Yang Jiang,Yapeng Han et al.
Tiantian Gao et al.
Background: Microplastics and nanoplastics, ubiquitous in ecosystems, pose significant ecological and health risks. At the biological level, plastics impact multiple trophic levels. While numerous studies have confirmed t...
Machine learning ensemble meets clinical practice: developing a real-world risk prediction model for metabolic syndrome using super learner and scorecard approaches [0.03%]
机器学习集成与临床实践相结合：使用超级学习器和评分卡方法开发代谢综合征的现实风险预测模型
Shuwen Li,Yu Zhang,Kang Fu et al.
Shuwen Li et al.
Introduction: Metabolic syndrome (MetS) refers to a cluster of metabolic abnormalities that significantly increase the risk of developing cardiovascular diseases (CVDs). Traditional binary definitions of MetS fall short i...
Aryl hydrocarbon receptor, a promising therapeutic target for ulcerative colitis, impairs HK2-controlled flux of hexosamine-biosynthesis pathway to eliminate NETosis in an N-glycosylation dependent manner [0.03%]
芳烃受体通过N-糖基化依赖的方式损害HK2控制的半乳糖胺生物合成途径通量以消除NETosis，有望成为治疗溃疡性结肠炎的新靶点
Shijia Li,Jingchao Zhu,Jie Song et al.
Shijia Li et al.
Introduction: The aryl hydrocarbon receptor (AhR) is a promising therapeutic target for ulcerative colitis (UC) and plays a role in regulating neutrophil function. ...
Enhancing NOx emission control and energy efficiency of H2/NH3 powered micro generator in a planar porous combustor [0.03%]
一种平面多孔燃烧器中H2/NH3驱动的微电站NOx减排及能效提升方法研究
Hao Wang,Qingguo Peng,Zhixin Huang et al.
Hao Wang et al.
Introduction: Micro-thermoelectric system fueled by hydrocarbon with the simple construction, no moving parts and high energy density, have garnered extensive attention. However, micro combustors are facing challenges of ...
Designing an apoptosis reporter by mutagenesis-based insertion of caspase-3 cleavage motif into green fluorescence protein [0.03%]
基于突变的插入半胱天冬酶-3切割基序到绿色荧光蛋白中的凋亡报告的设计
Dong Gil Lee,Hae-Jun Yang,Unbin Chae et al.
Dong Gil Lee et al.
Introduction: Apoptosis is an essential process for organisms and animal development, and its dysregulation is related to the progression of several diseases. Therefore, methods to detect apoptosis are necessary for mecha...