Four distinct pathways involved in a "tug-of-war" lead to the non-linear nature of phenolic chemistry during lactic acid fermentation of fruits and vegetables [0.03%]
水果和蔬菜乳酸发酵过程中，“拔河”所涉及的四条独特途径导致酚类化学的非线性特性
Yuqing Duan,Fanqiang Meng,Sivakumar Manickam et al.
Yuqing Duan et al.
Introduction Lactic acid fermentation of fruits and vegetables (F&V) is endowed with new nutrients and flavors. "Phenolics" is a hot spot in this area, which evolve irregularly during fermentation. However, the mechanism about this non-line...
Long non-coding RNA LINC01532 sustains redox homeostasis and accelerates lenvatinib resistance in hepatocellular carcinoma [0.03%]
长链非编码RNA LINC01532维持氧化还原稳态并加速肝细胞癌中对乐伐替尼的耐药性形成
Yang Hu,Muhua Chen,Shiqi Sun et al.
Yang Hu et al.
Introduction: Lenvatinib is the first-line therapy of hepatocellular carcinoma (HCC) and the high frequency of lenvatinib resistance hinders the improvement of HCC treatment. Since NADPH plays vital roles in antioxidant d...
NRIR promotes immune escape in hepatocellular cancer by regulating IFNγ-induced PD-L1 expression [0.03%]
NRIR通过调节IFNγ诱导的PD-L1表达促进肝细胞癌免疫逃逸
Yan Zhou,Jing Wang,Yuanhang Chen et al.
Yan Zhou et al.
Introduction: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with insensitive treatment and poor prognosis; in recent years, breakthroughs in IFN signaling pathway and PDL1/PD1 signal...
Tubular epithelial cell-derived Flt3L is required for type 1 conventional dendritic cell (cDC1) activation and expansion in promoting the recovery in acute kidney injury [0.03%]
管状上皮细胞衍生的Flt3L对于急性肾损伤中促进恢复的类型1常规树突细胞(cDC1)激活和扩增是必需的
Na Li,Stefanie Steiger,Yao Guo et al.
Na Li et al.
Introduction: Dendritic cells (DCs) play a crucial role in the recovery following acute kidney injury (AKI). Fms-related tyrosine kinase 3 ligand (Flt3L) is essential for the generation and maintenance of DCs. However, th...
Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells [0.03%]
等离子活化溶液通过调节间皮细胞中的eNOS表达来防止腹膜粘连的形成
Yuyi Ma,Tuanhe Sun,Kaijie Ren et al.
Yuyi Ma et al.
Introduction: Peritoneal adhesions cause significant morbidity due to limited therapeutic options. Current strategies are limited by inconsistent efficacy and potential side effects. Plasma-activated solutions (PAS) exhib...
An auxin response factor regulates tiller angle and shoot gravitropism by directly activating related gene expression in rice [0.03%]
一个生长素反应因子通过直接激活水稻中相关基因的表达来调控分蘖角度和茎秆向地性
Yanjuan Hu,Dan Xue,Shiyu Wang et al.
Yanjuan Hu et al.
Introduction: The angle of tillers is crucial for shaping plant architecture, which in turn affects grain yield of rice. The formation of tiller angle is associated with the asymmetrical distribution and polar transport o...
MTHFR variant links homocysteine metabolism and endothelial cell dysfunction by targeting mitophagy in human thoracic aortic dissection patient induced pluripotent stem cell (iPSC) models [0.03%]
MTHFR变异通过靶向人体胸主动脉瘤诱导多能干细胞(iPSC)模型的线粒体自噬来影响同型半胱氨酸代谢和内皮细胞功能失调
You Yu,Lianbo Shao,Meng Zhang et al.
You Yu et al.
Aims: Genetics and environmental cues boost the development of human diseases. Methylenetetrahydrofolate reductase (MTHFR) is involved in the metabolism of homocysteine, and a common variant rs1801133 of MTHFR has been re...
Digital twin-driven operational CycleGAN-based multiple virtual-physical mappings for remaining useful life prediction under limited life cycle data [0.03%]
基于数字孪生驱动的CycleGAN剩余使用寿命预测方法研究
Quanning Xu,Zihao Lei,Shulong Gu et al.
Quanning Xu et al.
Accurately predicting the remaining useful life (RUL) of complex equipment plays a vital role in maintaining modern manufacturing systems' operational safety and reliability. This challenge has attracted considerable interest within the dom...
Deep-DPC: Deep learning-assisted label-free temporal imaging discovery of anti-fibrotic compounds by controlling cell morphology [0.03%]
Deep-DPC：通过控制细胞形态实现抗纤维化化合物的无标记时序成像发现的深度学习辅助方法
Xu-Dong Xing,Xiang-Yu Yan,Yan-Wei Tan et al.
Xu-Dong Xing et al.
Introduction: Fibrosis can damage the normal function of many organs, such as cardiac function, for which no effective clinical therapies exist. However, traditional approaches to anti-fibrosis drug discovery have primari...
Cuticle thickening mediates insecticide penetration resistance in Spodoptera litura [0.03%]
表皮增厚介导烟芽夜蛾杀虫剂渗透抵抗
Bingjie Wang,Minghui Yi,Mengyu Wang et al.
Bingjie Wang et al.
Introduction: Long-term and extensive use of chemical pesticides has led to the development of resistance in many important agricultural pests. The mechanisms of resistance formation in pests are complex and variable, and...