Integrating biocatalysis with continuous flow: current status, challenges, and future perspectives [0.03%]
生物催化与连续流动工艺的结合：现状、挑战及未来展望
Jing Bai,Chen Huang,Yunting Liu et al.
Jing Bai et al.
Background: Continuous-flow biocatalysis is gaining attention for the synthesis of highly valuable pharmaceuticals and fine chemicals. The integrated approach combines the high activity and selectivity of biocatalysts wit...
Endothelial cells secrete small extracellular vesicles to promote neuron endoplasmic reticulum stress injury via miR-146a-5p/Eif4g2 axis in ischemic stroke [0.03%]
内皮细胞通过分泌小胞外囊泡促进缺血性卒中后神经元内质网应激损伤：miR-146a-5p/Eif4g2轴的作用机制研究
Meiqi Jin,Yueqiusha Wang,Shuxia Zhang et al.
Meiqi Jin et al.
Introduction: Ischemic stroke (IS) ranks among the top global causes of mortality and disability, with existing treatments proving inadequate because of its complex pathological process. Cell communication mediated by ext...
Tankyrase activity is essential for asymmetric division and chromosome segregation in oocyte meiosis [0.03%]
卵母细胞减数分裂中极体生成和染色体分离需要TANKYRASE活性
Ping-Shuang Lu,Zhen-Nan Pan,Wen-Lin Pan et al.
Ping-Shuang Lu et al.
Introduction: Tankyrase (TNKS) is a poly ADP-ribose polymerase which is known to regulate DNA repair, GLUT4-related vesicles transportation, and mitotic sister telomeres resolution. ...
Evanescent wave-based optical biosensors for innovations, medical application and future perspectives [0.03%]
基于倏逝波的光学生物传感器的新进展、医学应用及未来展望
Chen Chen,Rukmani Singh,Siyan Huo et al.
Chen Chen et al.
Background: Evanescent wave (EW)-based optical biosensors have rapidly evolved into indispensable tools for real-time, non-invasive, and ultra-sensitive detection of biomolecular interactions. By enabling label-free analy...
A general strategy for the efficient utilization of Microbiocide by using polyacrylic acid sodium as a flexible framework material [0.03%]
利用聚丙烯酸钠作为柔韧性骨架材料高效利用杀菌剂的策略
Weiyao Yan,Yuqi Huang,Gang Tang et al.
Weiyao Yan et al.
Introduction: Copper sulfide nanoparticles are ideal carrier materials for the preparation of controlled release nano-systems that can effectively improve the utilization efficiency and environmental safety of microbicide...
Cu-miRNA-mediated redox homeostasis explains the differences in cold tolerance between AAA and ABB banana varieties [0.03%]
Cu-miRNA介导的氧化还原稳态解释了AAA和ABB香蕉品种耐寒性差异
Kuan Peng,Xiangjin Kong,Yuci Li et al.
Kuan Peng et al.
Introduction: Banana fruit (Musa spp.) tend to suffer chilling injury but obvious differences exist in the cold tolerance among different banana genotypes. Cu-miRNAs refer to a group of miRNAs that target and regulate the...
Recent research progress and clinical status of immunotherapy for colorectal cancer [0.03%]
近年来免疫治疗在结直肠癌研究中的进展及临床应用状况
Zhikui Huo,Guoliang Liu,Jiannan Li
Zhikui Huo
Background: The incidence of colorectal cancer (CRC) is increasing worldwide, particularly among younger adults. Consequently, developing novel treatment strategies for CRC is necessary. As a recently developed therapeuti...
The GOLM1-ACLY pathway regulates macrophage-secreted EFEMP1 via H3K27ac modifications to drive tumor progression [0.03%]
GOLM1-ACLY途径通过H3K27ac修饰调节巨噬细胞分泌的EFEMP1以促进肿瘤进展
Lan Zhen,Min Min,Xinglin Mo et al.
Lan Zhen et al.
Background: Macrophages play crucial regulatory roles within the tumor immune microenvironment (TIME) and significantly influence tumor progression. GOLM1 has been identified as being closely associated with a variety of ...
Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial growth factor receptor 2 pathway in inflammatory bowel disease [0.03%]
转谷氨酰胺酶2通过血管内皮生长因子受体2信号通路调节炎症性肠病的炎性新生血管形成作用
Gaoshi Zhou,Mudan Zhang,Shuhui Zheng et al.
Gaoshi Zhou et al.
Objectives: Immune-driven inflammatory angiogenesis is a crucial component in the pathogenesis of inflammatory bowel disease (IBD). Nevertheless, the underlying mechanisms are still poorly understood. This study aims to i...
Redistribution of super-enhancers promotes malignancy in human hepatocellular carcinoma [0.03%]
超级增强子的重新分布促进人类肝细胞癌恶性发展
Jiacheng Huang,Liang Xu,Ye Chen et al.
Jiacheng Huang et al.
Introduction: Super-enhancers (SEs) are defined as the regulatory region where intensive transcriptional cofactors bind. Dysregulation of SEs is related to multiple diseases, however, its role in hepatocellular carcinoma ...