Integrative proteomic characterization of human lung adenocarcinoma with KRAS G12 mutations reveals molecular pathogenesis [0.03%]
人肺腺癌中KRAS G12突变的整合性蛋白质组特征分析揭示分子病理机制
Xinyu Shi,Liling Hu,Yongshi Huang et al.
Xinyu Shi et al.
Introduction: Integrated proteogenomic studies of lung adenocarcinoma (LUAD) have provided unique insights with potential clinical effects. Comprehensive proteomic analyses are needed to better understand the molecular la...
The eternal struggle between titans: Fecal microbiota transplant (FMT) versus metformin in type 2 diabetes (T2D) gut dysmotility [0.03%]
Titans之间的永恒之争：2型糖尿病（T2D）肠道动力障碍粪菌移植(FMT)vs二甲双胍治疗
Lucia La Sala,Valentina Carlini,Maria Belen Macas-Granizo et al.
Lucia La Sala et al.
Background: The prevalence of dysbiosis in type 2 diabetes (T2D) is increasing globally as a consequence of an imbalance in the distribution of gut microbial populations. Dysmotility of the gastrointestinal tract has emer...
The global burden of non-communicable diseases attributable to behavioral risk factors and its trends from 1990 to 2021 [0.03%]
1990年到2021年全球非传染性疾病归因于行为危险因素的疾病负担及其趋势
Xiaohan Geng,Fengzhi Liang,Peigang Wang
Xiaohan Geng
Background: Non-communicable diseases (NCDs) are one of the major challenges to global public health. High alcohol use, dietary risks, and low physical activity are three risk factors that can increase the burden of NCDs....
Mitochondrial dysfunction drives ZBP1-mediated PANoptosis to increase the susceptibility of heart failure with preserved ejection fraction-associated atrial fibrillation [0.03%]
线粒体功能障碍通过ZBP1介导的PANoptosis促进射血分数保留心力衰竭相关房颤易感性增加
Jinfeng Duan,Zijun Cao,Zijun Zhou et al.
Jinfeng Duan et al.
Introduction: Heart failure with preserved ejection fraction (HFpEF) is frequently complicated by atrial fibrillation (AF), but underlying molecular mechanisms remain poorly defined. Mitochondrial dysfunction drives ZBP1-...
Dissemination of antimicrobial resistance in Klebsiella spp. from urban aquatic environments: a multi-country genomic perspective [0.03%]
城市水环境中抗微生物药物耐药性的传播：来自多个国家的基因组视角克雷伯菌属抗菌药 resistant klebsiella spp. 的扩散：多国基因组学观点
Zelin Yan,Yan Li,Xiaoyang Ju et al.
Zelin Yan et al.
Introduction: Antibiotic resistance, particularly carbapenem-resistant Klebsiella pneumoniae (CRKP), poses significant clinical and environmental threats, especially in urban aquatic ecosystems and hospital wastewaters. ...
Nutrition cycling microbiomes drive the succession of antibiotic resistome in long-term manured soils [0.03%]
长期施用粪肥土壤中营养循环微生物群驱动抗生素抗性基因组的演替
Conglai Zheng,Jiajin Song,Mei Shan et al.
Conglai Zheng et al.
Introduction: The spread of antibiotic resistance genes (ARGs) in the environment has received widespread attention. Nutrition cycling microbiomes specifically refer to microorganisms capable of mineralizing nitrogen and ...
Tirzepatide retention in iWAT with mesoporous polydopamine encapsulation enhances weight loss through leptin receptor signaling [0.03%]
负载胰脂素受体的介观多巴胺囊封包改善司美格鲁肽在iWAT中的滞留以增强减重作用
Lin Mi,Tan Li,Xiaoxin Xiang et al.
Lin Mi et al.
Introduction: Tirzepatide (TZP), a dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, has been showing superior benefits in weight loss and glucose lowering in patients with obesit...
Decoding the functional network of circular RNAs encoding proteins in hepatocellular carcinoma: from carcinogenesis to clinical transformation [0.03%]
肝细胞癌中编码蛋白质的环状RNA功能网络的解码：从致癌机制到临床转化
Jundan Zheng,Tianle He,Jiaxin Chen et al.
Jundan Zheng et al.
Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy with limited therapeutic options. Circular RNAs (circRNAs) have emerged as key regulators in HCC. They influence oncogenic pathways by acting...
Advances in high-throughput drug screening based on pharmacotranscriptomics [0.03%]
基于药理转录组学的高通量药物筛选研究进展
Liansheng Qiao,Xiaoqian Huo,Wenting Huang et al.
Liansheng Qiao et al.
Background: Drug screening constitutes the predominant paradigm for novel drug discovery. With the development of omics, drug screening has gradually developed into pharmacotranscriptomics-based drug screening (PTDS), whi...
Mechanism insights into the regulation of the LuxS/AI-2 quorum sensing system on the formation of viable but nonculturable state in biofilm cells of beer-spoilage Lactiplantibacillus plantarum [0.03%]
关于啤酒腐败植物乳杆菌生物被膜细胞存活但非培养状态形成的LuxS/AI-2群体感应系统的调控机制研究
Xuchen Li,Guoqing Wei,Wenhui Wang et al.
Xuchen Li et al.
Introduction: Beer spoilage Lactiplantibacillus plantarum poses a significant challenge in brewing due to biofilm formation and entry into the viable but nonculturable (VBNC) state, evading detection and resisting sterili...