Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DDX5-ATF1-PPP2R5A signaling [0.03%]
类似于转导的分裂增强子3通过DDX5-ATF1-PPP2R5A信号传导保护脂多糖诱导的炎症反应
Di Fan,Yi Zhong,Yin Dong et al.
Di Fan et al.
Introduction: Sepsis consists of life-threatening multi-organ dysfunction caused by an excessive systemic inflammatory response to infection. Therefore, identifying negative regulators of innate inflammation is crucial fo...
From repellent to risk: DEET's adverse effects on hormones and bone health in kids [0.03%]
从驱避剂到风险：DEET对儿童荷尔蒙和骨骼健康的不良影响
Xinyu Zhu,Wanlu Liu,Baihao Lin et al.
Xinyu Zhu et al.
Introduction: Early life bone accumulation, which predicts future fragility fracture risk, is intimately associated with sex hormones. N, N-diethyl-3-methylbenzamide (DEET) is the primary and most effective active ingredi...
Pathogenicity of novel GLA gene missense mutations in Fabry disease and the therapeutic impact of migalastat [0.03%]
费布里病中GLA基因错义突变的新致病性以及 Migalastat的治疗效果
Wenkai Guo,Pengcheng Ji,Yaqing Li et al.
Wenkai Guo et al.
Introduction: Fabry disease, a rare X-linked hereditary lysosomal storage disorder caused by mutations in the GLA gene, affecting multiple organs. However, functional validation data on the pathogenicity of newly identifi...
A mouse model of sepsis-associated DIC induced by Kappa-carrageenan and Lipopolysaccharides: Establishment and characteristics [0.03%]
κ-卡拉胶和脂多糖诱导的脓毒症相关DIC小鼠模型的建立及特点
Ping Tang,Boning Huang,Qianqing Ou et al.
Ping Tang et al.
Background: No animal models fully replicate the pathogenesis and clinical features of sepsis-associated disseminated intravascular coagulation (DIC), which hinders mechanistic understanding and treatment development. Kap...
Inhalation exposure to tire rubber particle-sourced pollutant 6PPD-quinone involving basolateral amygdala impairment in male ICR mice [0.03%]
轮胎橡胶颗粒源污染物6PPD醌的吸入暴露导致ICR雄性小鼠基底外侧杏仁核损伤
Qu-Nan Wang,Chunzhi Wang,Yán Wāng
Qu-Nan Wang
Introduction: The extensive use of 6PPD in tire rubber has led to its increase in atmospheric tire wear particles. 6PPD reacts with ozone to form 6PPD-quinone (6PPD-Q), a respiratory toxicant enriched in tire and road wea...
Discovery of mannose as an alternative non-nutrient-deficient regulator of lipid accumulation in microalgae [0.03%]
发现甘露糖作为微藻中脂质积累的替代非营养缺乏型调节因子
Pengyang Liu,Yuanhang Ai,Muzi Li et al.
Pengyang Liu et al.
Introduction: Microalgae are considered promising bioenergy producers, but their commercial potential is limited by low lipid yields. Nutrient deprivation, particularly nitrogen starvation, is a primary strategy to enhanc...
Spatiotemporal translation of sperm acrosome associated proteins during early capacitation modulates sperm fertilizing ability [0.03%]
精子获能早期与精子顶体相关的蛋白的时空转化调节了精子的受精能力
Yoo-Jin Park,Won-Ki Pang,Do-Yeal Ryu et al.
Yoo-Jin Park et al.
Introduction: Despite the lack of essential cytoplasmic organelles in mature spermatozoa, which creates unfavorable conditions for transcription and translation, the presence of various mRNA and proteins during capacitati...
Evidence for the role of soil C/N ratio in shaping plant responses to root-knot nematode infection [0.03%]
土壤C/N比率在塑造植物对根结线虫感染的反应中的作用的证据
Jiafan Li,Shikai La,Mengyuan Song et al.
Jiafan Li et al.
Introduction: Root-knot nematodes (RKNs) pose a major threat to global crop production. Soil properties influence plant responses to RKN infestation, but the specific soil factors that are most influential in determining ...
Mitochondrial fatty acid oxidation as the target for blocking therapy-resistance and inhibiting tumor recurrence: The proof-of-principle model demonstrated for ovarian cancer cells [0.03%]
线粒体脂肪酸氧化作为阻断治疗抵抗和抑制肿瘤复发的靶点：以卵巢癌细胞为原理证明模型
Hui Lin,Lingfang Wang,Hanwen Chen et al.
Hui Lin et al.
Introduction: Cancer patients treated with current chemotherapeutic and targeted therapies frequently achieve partial remission, which ultimately relapse with more aggressive, drug-resistant tumor phenotypes. To a certain...
Minichromosome maintenance 4 plays a key role in protecting against acute kidney injury by regulating tubular epithelial cells survival and regeneration [0.03%]
微型染色体维持蛋白4通过调节管状上皮细胞的存活和再生在保护急性肾损伤中起关键作用
Jing Huang,Feng Liu,Zhi-Feng Xu et al.
Jing Huang et al.
Introduction: Minichromosome maintenance 4 (MCM4), a constituent of the MCM family, playing a pivotal role in DNA replication. Although MCM4 expression has been widely linked to various malignant tumors, its role in kidne...