Drug-resistant Escherichia coli metabolomics via pseudo-targeted SWATH/IDA-MRM: Bridging high coverage and precision [0.03%]
基于伪靶标的SWATH/IDA-MRM方法解析耐药大肠杆菌代谢组高覆盖与精准之间的桥梁研究
Xi Jia,Liang Zhao,Saiwa Liu et al.
Xi Jia et al.
Introduction: Metabolic reprogramming plays a significant role in the emergence, progression, and response to antibiotic pressure in bacterial resistance. Current metabolomics approaches face significant limitations: unta...
Enhanced tuberculosis control via leveraging dendritic cell-mediated Th1 responses in preventive and immunotherapeutic vaccine strategies [0.03%]
利用树突状细胞介导的Th1反应增强预防性和免疫治疗性疫苗策略中的结核病控制能力
Hongmin Kim,Jong-Seok Kim,Kee Woong Kwon et al.
Hongmin Kim et al.
Introduction: Insufficient vaccine efficacy of the Bacillus Calmette-Guérin (BCG) and long, expensive tuberculosis (TB) treatments highlight the need for better TB control measures. ...
Comprehension of the age-dependent gut and brain interaction of honey bee workers by integration of multi omics approaches [0.03%]
通过整合多组学方法理解工蜂肠道和大脑的年龄依赖性相互作用
Cassandra Uthoff,Yelyzaveta Yakovlyeva,Beatrice Engelmann et al.
Cassandra Uthoff et al.
Introduction: In honey bees, division of labour is a key feature, with age-related behavioural transitions being closely associated with molecular changes in the brain, gut, and microbiota. Despite evidence of both microb...
Multi-target regulation by artemether in MAFLD through EGFR/HSP90 pathways [0.03%]
青蒿琥酯通过EGFR/HSP90信号通路多靶点调控MAFLD
Jia Xu,Bingxin Huangfu,Teng Wang et al.
Jia Xu et al.
Introduction: The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is rising, while current pharmacological treatments are often limited by adverse effects. Artemether (Art), a derivative of arte...
Immunometabolism of macrophages in the bone microenvironment: a new perspective for bone healing therapy [0.03%]
骨微环境中的巨噬细胞免疫代谢：骨愈合治疗的新视角
Chenyu Wang,Qihang Wu,Luyao Zhuang et al.
Chenyu Wang et al.
Background: Immunometabolism, the regulation of immune cell function through metabolic pathways, has emerged as a key focus in regenerative medicine. Traditional bone healing therapies primarily target the osteoblast-oste...
Human serum albumin-derived biosensor for visualizing copper(II) and hydrogen sulfide interactions in cancer cells [0.03%]
人血清白蛋白衍生的可视化铜离子和硫化氢在癌细胞中相互作用的生物传感器
Yong An,Yucen Zhou,Linghua Zhang et al.
Yong An et al.
Introduction: Accurate monitoring of Cu2+ and H2S levels is one of the most reliable methods for diagnosing tumors and assessing treatment efficacy. However, the development of fluorescent probes capable of detecting Cu2+...
Shuguang Liu,Shichun Wang,Yibo Dong et al.
Shuguang Liu et al.
Background: Blood is best known for its critical roles such as oxygen distribution, nutrient transport, hemostasis, and immune surveillance. However, its impact on biological aging remains unknown. Accumulating evidence i...
NCOA4-Mediated ferritinophagy induces ferroptosis and enriches ferritin-containing EVs via ferritin phase separation to promote mechanical ventilation-induced pulmonary fibrosis [0.03%]
NCOA4介导的铁蛋白自噬通过铁蛋白相分离诱导铁死亡并富集含铁蛋白的外泌体以促进机械通气诱发肺纤维化
Xi Huang,Jinhua Feng,Qiaoyi Xu et al.
Xi Huang et al.
Introduction: Mechanical ventilation (MV) is essential for treating respiratory failure but can paradoxically lead to pulmonary fibrosis. The mechanisms of MV-induced pulmonary fibrosis (MVPF) remain poorly understood. Fe...
Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism [0.03%]
硼酸衍生物通过破坏能量代谢抑制白念珠菌生长
Suhua Wu,Venkatesh Mayandi,Eunice Tze Leng Goh et al.
Suhua Wu et al.
Introduction: Fungal infections represent a global health concern with significant implications for human well-being. Among them, refractory and sight-threatening fungal keratitis (FK) poses a serious threat to ocular hea...
Harnessing GhGRDP1 natural variation for enhanced cotton seed yield: a rhamnose-dependent strategy in breeding [0.03%]
利用GhGRDP1自然变异提高棉籽产量：一种育种中的鼠李糖依赖性策略
Yongyan Zhao,Hongyu Wu,Ting Zhao et al.
Yongyan Zhao et al.
Introduction: Breeding high-yield crops has long been a fundamental goal in global agriculture, with seeds serving as the essential vehicle to achieve this aim. Therefore, understanding the regulatory mechanisms of seed s...