Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases [0.03%]
正常老化和多种神经系统疾病中正常外观的皮质脊髓束的室管膜周围梯度变化规律
Zhizheng Zhuo,Xiaolu Xu,Decai Tian et al.
Zhizheng Zhuo et al.
Introduction: A potential inflammation-associated periventricular gradient of normal-appearing white matter (NAWM) abnormalities has been identified in multiple sclerosis, but its presence in normal aging and other neurol...
Disphosphate based hydrogel microspheres for targeted transarterial radioembolization and chemoembolization therapies [0.03%]
基于二磷酸盐的水凝胶微球用于靶向载药栓塞治疗
Xuexiao Li,Binyan Zhong,Nan Jiang et al.
Xuexiao Li et al.
Introduction: Transarterial radioembolization (TARE) is a highly effective treatment for unresectable hepatocellular carcinoma (HCC). However, current clinically available radioactive 90Y resin microspheres face significa...
Advances in physical and chemical strategies for dentin hypersensitivity therapy [0.03%]
牙本质敏感症治疗的物理和化学策略进展
Xinru Li,Qihui Wang,Yirong Sun et al.
Xinru Li et al.
Background: Dentin hypersensitivity (DH) is a prevalent and acute dental pain disorder marked by a brief yet sharp toothache caused by exposed dentin, often in response to thermal, chemical, and mechanical stimuli. It sig...
Roles of Msx2 in exogen control: modulating the stem cell niche during the transition from hair shedding to regeneration [0.03%]
Msx2在毛襄外根鞘细胞凋亡调控中的作用：在休止期向生长期转变过程中调节干细胞龛环境的作用
Qi Chen,Wen-Chien Jea,Ting-Xin Jiang et al.
Qi Chen et al.
Introduction: The exogen phase of the hair follicle cycle, during which club hairs are shed and new hairs emerge, represents a critical transitional step involving distinct structural remodeling and adhesive changes. Desp...
Bisphenol S drives breast cancer metastasis by inhibiting dopamine receptor D2 to activate the Akt/GSK3β oncogenic axis [0.03%]
双酚S通过抑制多巴胺受体D2活化Akt/GSK3β致癌轴促进乳腺癌转移
Sicheng Liu,Ping Deng,Chengmeng Liu et al.
Sicheng Liu et al.
Introduction: Bisphenol S (BPS), a substitute for bisphenol A (BPA), serves as an endocrine disruptor implicated in breast cancer (BC) progression, but its mechanisms remain unclear. ...
Olfactory-gustatory cross-modal integration: mechanisms of aroma-induced sweetness enhancement, sensory evaluation methodologies, neuroimaging evidence and advances in influencing factors [0.03%]
嗅觉-味觉跨模态整合：香气致甜增效的机制、感官评定方法、神经影像学证据及影响因素进展
Yanli Tan,Xueli Pang
Yanli Tan
Background: Excessive sugar intake induces health issues such as excess energy, obesity and cardiovascular diseases. Reducing sugar consumption has become a global consensus; however, achieving this without compromising f...
Orthosteric-allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer [0.03%]
具有抗癌活性的PI5P4Kγ正则变构双重抑制剂
Liang Xiong,Lei Tang 唐磊,Wenfeng Zhao et al.
Liang Xiong et al.
Introduction: Phosphatidylinositol 5-phosphate 4-kinase type II gamma (PI5P4Kγ) has emerged as a promising therapeutic target in oncology due to its key role in cancer progression. However, currently available inhibitors...
Development and clinical validation of a novel protein biomarkers-based algorithm for risk prediction and diagnosis of advanced liver fibrosis: a multi-centre study [0.03%]
新型蛋白生物标志物算法在肝纤维化风险预测及诊断中的开发和临床验证：多中心研究
Chloe Yu-Yan Cheung,Pei Wan,Heng Wan et al.
Chloe Yu-Yan Cheung et al.
Introduction: Type 2 diabetes (T2D) and obesity contribute significantly to the elevated risk of liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD). However, there is a lack of reliable and...
Integrative epitranscriptomic and transcriptomic characterization in human colorectal cancer [0.03%]
人类结直肠癌中的表观转录组和转录组的综合分析
Ting Gong,Sudhir Kumar Rai,Yong Zhu et al.
Ting Gong et al.
Introduction: Despite significant progress in understanding the molecular basis of colorectal cancer (CRC), the precise mechanisms driving its development and progression remain poorly defined. This gap limits the identif...
Charge reversible-natural light responsive nanoparticles enable targeted herbicide delivery and reduction of mammalian toxicity [0.03%]
可逆性响应天然光线的纳米粒子实现除草剂靶向投递并降低对哺乳动物的毒性
Junhu Xu,Wei Wang,Kunyan Guo et al.
Junhu Xu et al.
Introduction: Mammalian health risks due to agrochemical exposure are becoming a global concern, increasingly. Long-term exposure to diquat (DQ) leads to multiple organ dysfunctions and increase mammal mortality. Despite ...