Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation [0.03%]
刺突RBD通过小胶质细胞-神经元交叉对话介导的RTP801上调驱动帕金森病的持续进展
Sha-Sha Wang,Ruo-Lan Yuan,Wen-Fei Wang et al.
Sha-Sha Wang et al.
Introduction: Emerging evidence highlights the exacerbation and sustained Parkinson's disease (PD) progression following COVID-19. The SARS-CoV-2 spike receptor-binding domain (RBD), which can persist in the brain post-in...
Yan Wang,Xinyu Huang,Guiying Wu et al.
Yan Wang et al.
Background: In the realm of biomedical research and clinical practice, the identification and accurate detection of biomarkers have become increasingly critical. Biomarkers serve as key indicators for disease diagnosis, p...
Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft [0.03%]
组织工程神经移植物促进外周神经再生背根神经节动态分子景观的研究
Hui Zhu,Siyuan Xu,Yiting Wang et al.
Hui Zhu et al.
Introduction: The limited regenerative capacity of the nervous system represents a significant clinical challenge in the context of peripheral nerve injuries. An innovative strategy for sciatic nerve repair has been devel...
Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1 [0.03%]
乳酸通过稳定TGF-β1加重PM2.5诱导的肺纤维化
Zhihao Liu,Wei Liu,Huaiqing Wei et al.
Zhihao Liu et al.
Introduction: Lactate, a glycolysis byproduct, has been implicated in the fibrotic process, while transforming growth factor-beta 1 (TGF-β1) plays a central role in promoting fibrosis. Air pollution, particularly fine pa...
Fingernail-based metabolomics reveals a stepwise decline in dodecanoic acid associated with Alzheimer's disease progression [0.03%]
基于指甲的代谢组学揭示月桂酸在阿尔茨海默病进展中的逐步下降
Wenbo Zhang,Jiani Wu,Zhangjing Deng et al.
Wenbo Zhang et al.
Background: Fingernail metabolomics provides a novel, non-invasive platform that captures long-term biochemical fluctuations for identifying reliable biomarkers for dementia and mild cognitive impairment (MCI) due to Alzh...
DAMP signaling networks: from receptors to diverse pathophysiological functions [0.03%]
DAMP信号网络：从受体到多种病理生理功能
Ruochan Chen,Ju Zou,Xiao Zhong et al.
Ruochan Chen et al.
Background: Damage-associated molecular patterns (DAMPs) are endogenous molecules released or exposed during cellular stress, injury, or death. Initially characterized as danger signals that alert the immune system, DAMPs...
Nur77 attenuates Paneth cell necroptosis-induced intestinal inflammation through regulating endoplasmic reticulum homeostasis in sepsis [0.03%]
Nur77通过调节内质网稳态来减弱脓毒症中的潘氏细胞坏死诱导的肠道炎症
Chenbin Cui,Qiyuan Huo,Sijiao Ran et al.
Chenbin Cui et al.
Introduction: Sepsis, a systemic inflammatory syndrome, is frequently associated with intestinal dysfunction, which in turn exacerbates disease severity. Intestinal epithelial Paneth cells exhibit increased susceptibility...
Valorization of broccoli waste: Unlocking its potential as a functional food ingredient for sustainable nutrition [0.03%]
broccoli废弃物的再利用：解锁其作为功能性食品成分用于可持续营养的潜力
Qian Wang,Yaqi Zhao,Wenyuan Zhang et al.
Qian Wang et al.
Background: Broccoli waste, primarily comprising of stems and leaves discarded during processing, represents an underutilized resource with significant potential for food applications. However, its nutritional composition...
Global genomics of Lactococcus lactis: Horizontal gene transfer and intergenic variation drive multiple domestication and dairy adaptation [0.03%]
乳酸链球菌的全球基因组：水平基因转移和非编码区变异驱动多种驯化与奶酪适应性
Weicheng Li,Jiaqi Sun,Qiong Wu et al.
Weicheng Li et al.
Introduction: Lactococcus lactis is a crucial lactic acid bacterium of great economically significance for cheese product. The species exhibits wildly distribution and significant genetic diversity, yet the underlying dri...
Regulatory mechanisms of quorum sensing in microbial communities and their potential applications in ruminant livestock production [0.03%]
微生物群落中的准量感应调节机制及其在反刍动物生产中的潜在应用
Menglin Li,Guangyong Zhao,Meng M Li
Menglin Li
Background: Quorum sensing (QS) is a cell-to-cell communication system that enables microbial communities to dynamically regulate their metabolism and physiological activities according to the surrounding cell density. Th...