Comprehensive insights into emerging advances in the Neurobiology of anorexia [0.03%]
厌食症神经生物学新进展的全面见解
Liwei Mao,Lian Wang,Zhihai Huang et al.
Liwei Mao et al.
Anorexia is a complex eating disorder influenced by genetic, environmental, psychological, and socio-cultural factors. Research into its molecular mechanisms and neural circuits has deepened our understanding of its pathogenesis. Recent adv...
Multifunctional nanoplatform for tumor chemodynamic and self-amplified photodynamic cascade therapy [0.03%]
用于肿瘤化疗动力学和自放大光动力级联治疗的多功能纳米平台
Xingyu Luo,Haifeng Qi,Manqi Yan et al.
Xingyu Luo et al.
Introduction: 5-Aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) has demonstrated considerable potential in breast cancer treatment. However, its efficacy is limited by low tissue selectivity and the rapid con...
Thousands-years-old deep-sea DNA viruses reveal the evolution of human pathogenic viruses [0.03%]
千年前的深海DNA病毒揭示了人类病原病毒的进化路径
Tianliang He,Xinyi Zhang,Xiaobo Zhang
Tianliang He
Introduction: In the last two decades, outbreaks of pathogenic viruses have led to significant human mortality and economic repercussions. Despite extensive investigations into tracing these viruses in terrestrial environ...
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production [0.03%]
二甲双胍通过减少乙酰辅酶A的生成来阻断STAT3乙酰化从而缓解结肠炎
Xiangyun Li,Zixuan Xiang,Xiaoli Wang et al.
Xiangyun Li et al.
Background and aims: While metformin has been shown to alleviate dextran sulfate sodium (DSS)-induced colitis in murine models, the mechanisms underlying its anti-inflammatory and barrier-restorative effects remain poorly...
Loss of life expectancy attributed to long-term ozone exposure in Chinese older adults: Cross-cohort analysis from 3 national cohorts [0.03%]
基于中国三大队列的跨队列分析：长期臭氧暴露导致老年人寿命损失年增加
Minjin Peng,Yang Yuan,Haitong Zhe Sun et al.
Minjin Peng et al.
Background: Cohort evidence linking ozone (O3) exposure with mortality was sparsely investigated among the elderly in low- and middle-income countries. This study aims to quantify mortality risk and burden attributed to c...
Exploiting metabolic vulnerabilities through synergistic ferroptosis and disulfidptosis for breast cancer therapy [0.03%]
通过协同铁死亡和二硫化物来利用代谢脆弱性进行乳腺癌治疗
Yu Liang,Haibo Lan,Qiuyu Li et al.
Yu Liang et al.
Introduction: Ferroptosis represents a promising therapeutic approach for breast cancer treatment. However, cancer cells can develop resistance through the SLC7A11-GSH-GPX4 axis, wherein increased SLC7A11 expression enhan...
Online and personalised control of the Depth of hypnosis during induction using fractional order PID [0.03%]
诱导过程中使用分数阶PID进行在线和个性化的催眠深度控制
Marcian Mihai,Isabela Birs,Erwin Hegedus et al.
Marcian Mihai et al.
Introduction: The integration of information technology and control engineering has significantly increased in clinical practice research, especially in the management of drug dosing for general anaesthesia. ...
Prediction of influenza virus infection based on deep learning and peripheral blood proteomics: A diagnostic study [0.03%]
基于深度学习和外周血蛋白质组学的流感病毒感染预测：一项诊断研究
Yumei Zhou,Pengbo Wang,Haiyun Zhang et al.
Yumei Zhou et al.
Isntroduction. Influenza viruses cause seasonal epidemics almost every year, and it is difficult to diagnose quickly and accurately. Machine learning and peripheral blood protein omics have brought new ideas to the research of clinical mark...
The Application of artificial intelligence in periprosthetic joint infection [0.03%]
人工智能在关节置换周围感染中的应用
Pengcheng Li,Yan Wang,Runkai Zhao et al.
Pengcheng Li et al.
Periprosthetic joint infection (PJI) represents one of the most devastating complications following total joint arthroplasty, often necessitating additional surgeries and antimicrobial therapy, and potentially leading to disability. This si...
Carbon dot superoxide dismutase nanozyme enhances reactive oxygen species scavenging in diabetic skin wound repair [0.03%]
碳点超氧化物歧化酶纳米酶提高糖尿病皮肤伤口愈合过程中活性氧的清除能力
Zhu Yan,Yufei Zhang,Qin Chen et al.
Zhu Yan et al.
Introduction: The accumulation of reactive oxygen species (ROS) in diabetic wounds leads to inflammation and impaired neovascularization. Recent studies have indicated that carbon dot nanozymes (C-dots) exhibiting superox...