Noninvasive imaging-based assessment of tumor-associated neutrophils for prognosis and immunotherapy response in gastric cancer: a multicenter study [0.03%]
基于无创影像的肿瘤相关中性粒细胞评估在胃癌预后和免疫治疗反应中的作用：一项多中心研究
Wenbo Zheng,Zepang Sun,Wei Wang et al.
Wenbo Zheng et al.
Introduction: Tumor-associated neutrophils (TAN) critically promote gastric cancer progression. However, current assessment relies on invasive biopsies that preclude serial monitoring. Noninvasive tools to quantify TAN in...
Ythdf2 loss in microglia aggravates ischemic retinopathy by increasing microglia activation and microvascular anomalies [0.03%]
Ythdf2丢失加剧小胶质细胞活化和微血管异常加重缺血性视网膜病
Hong-Jing Zhu,Yi-Chen Zhang,Ye-Ran Zhang et al.
Hong-Jing Zhu et al.
Introduction: Microvascular dysfunction is a key contributor to life-threatening diseases, with retinal microvascular diseases being a leading cause of blindness. Aberrant microglia activation is critical in microvasculop...
Chromosome-level genome of wild-simulated Panax ginseng identifies SNP markers for germplasm and medicinal quality evaluation [0.03%]
野生栽培人参染色体水平基因组鉴定用于种质和药用品质评价的SNP标记
Xuejiao Liao,Yidan Xi,Baosheng Liao et al.
Xuejiao Liao et al.
Introduction: Panax ginseng C. A. Mey., a precious traditional medicinal herb, demonstrates diverse pharmacological activities, including immunomodulation and anti-fatigue effects. However, prolonged cultivation has led t...
Simultaneous engineering of the surface (oxygen/amorphous carbon) and interface (amorphous carbon/ZnO) of ZnO using a one-spoon amorphous carbon deposition technique [0.03%]
使用一锅法制备无定形碳同时工程ZnO的表面（氧/无定形碳）和界面（无定形碳/ZnO）
Jimyeong Park,Minseo Kim,Changhyun Jin et al.
Jimyeong Park et al.
Amorphous carbon/ZnO porous nanosheets (aC/ZnO PNSs) were synthesized using an innovative one-spoon amorphous carbon deposition (OSaCD) coating technique combined with water quenching during flame chemical vapor deposition (FCVD). The coati...
Unmasking human T cell receptor germline diversity: 335 novel alleles identified in 47 Pangenome reference individuals using the gAIRR Suite [0.03%]
揭开人类T细胞受体基因多样性：利用gAIRR套件在47个泛基因组参考个体中鉴定出的335种新等位基因
Yu-Hsuan Yang,Chi-Yuan Yao,Mao-Jan Lin et al.
Yu-Hsuan Yang et al.
Introduction: The adaptive immune receptor repertoire (AIRR), also referred to as expressed AIRR (exprAIRR) for clarity, comprises V(D)J-recombined T cell receptors (TR) and immunoglobulins (IG), and is central to adaptiv...
Skin regeneration axis under metal-based nanozymes: from chronic wound healing to structural and functional restoration [0.03%]
基于金属类酶纳米材料的皮肤再生轴：从慢性伤口愈合到结构与功能重塑
Ze-Ming Zhuang,Kai Guo,Zhang-Rui Wu et al.
Ze-Ming Zhuang et al.
Background: Diabetic infected wounds, representing a prototypical model of chronic non-healing wounds, leading to severe impairment of skin regeneration. However, complete skin restoration requires more than just wound cl...
Asprosin-driven metabolic-epigenetic rewiring attenuates mesenchymal stem cell senescence with therapeutic benefits for infarcted hearts [0.03%]
由Asprosin驱动的代谢-表观遗传重构可减轻间充质干细胞衰老并有利于心梗心脏治疗
Zhengbin Zhang,Ziqian Wang,Liwen Zhu et al.
Zhengbin Zhang et al.
Introduction: Senescent mesenchymal stem cells (MSCs) exhibit impaired self-renewal, limiting their therapeutic potential. While multi-omics have revealed downregulation of pan-tissue Fbn1 with aging, particularly in MSCs...
Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin [0.03%]
无创且无痛的中红外光调制可增加人类和小鼠皮肤中的胶原蛋白
Zeyu Wang,Jiahui Zhu,Yuting Wang et al.
Zeyu Wang et al.
Introduction: Stimulating collagen production is a key strategy for enhancing skin vitality and counteracting aging. However, current methods to boost collagen synthesis often entail pain and tissue trauma. There is a com...
An injectable microsphere-reinforced system for sustained delivery of Adipo-MBV in adipose tissue engineering [0.03%]
一种在脂肪组织工程中用于持续递送Adipo-MBV的可注射微球增强系统
Mimi Xu,Jianwei Chen,Yi Sun et al.
Mimi Xu et al.
Introduction: Tissue engineering has become prominence in soft tissue reconstruction. Adipogenesis and angiogenesis are important in the formation of engineering adipose tissue. Although acellular adipose matrix (AAM) pos...
Optimizing water allocation in irrigation districts for enhanced sustainability and climate resilience [0.03%]
灌溉区水资源优化分配以增强可持续性和气候韧性
Yingshan Chen,Mo Li,Qiang Fu et al.
Yingshan Chen et al.
Introduction: Irrigation plays a crucial role in enhancing agricultural productivity. However, it simultaneously increases water consumption and greenhouse gas (GHG) emissions, a challenge that is further exacerbated by c...