Achieving stable blue coloration of anthocyanins through pH-Modulated protein complexation [0.03%]
通过pH调节的蛋白质复合作用实现稳定蓝色花色苷染料
Wenxin Wang,Susana Soares,João T S Coimbra et al.
Wenxin Wang et al.
Introduction: Natural blue colorants are exceptionally scarce, and achieving stable blue hues from anthocyanins typically requires structural features such as extensive acylation or metal complexation, which limits their ...
Development of 3-carboxypropyl-grafted bio-inorganic lamellar nanocomposite as a new oral delivery platform for therapeutic peptides [0.03%]
开发具有3-羧基丙基接枝的生物无机层状纳米复合材料作为治疗肽的新口服传递平台
Jiwon Park,Gyu Lin Kim,Sang Hoon Lee et al.
Jiwon Park et al.
Introduction: One of the primary challenges in developing peptide drugs lies in their low permeability and inherent instability. Therefore, formulations that stabilize peptides and enhance the membrane transport are cruci...
4-Octyl itaconate-induced Nrf2 nuclear translocation mitigates Caspase-11-dependent noncanonical macrophage pyroptosis and acute lung injury [0.03%]
辛酰衣康酸诱导Nrf2核转位缓解非经典依赖的Caspase-11小胶质细胞pyroptosis和急性肺损伤
Tingyu Wen,Jindian Shi,Minkang Guo et al.
Tingyu Wen et al.
Introduction: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe inflammatory conditions, with mortality rates reaching 40%. A key driver of their pathogenesis is macrophage pyroptosis, whic...
Aloe-emodin alleviates osteoarthritis and maintains cytoskeletal homeostasis via targeting Septin7 ubiquitination [0.03%]
大黄素通过靶向Septin7泛素化来缓解骨关节炎和维持细胞骨架稳态
Peifeng Li,Zhen Chen,Zijian Zhang et al.
Peifeng Li et al.
Introduction: Osteoarthritis (OA) is the leading cause of disability worldwide. Due to its complex pathogenesis, no disease-modifying therapies currently exist to halt its progression. Consequently, there is an urgent cli...
Renal tubular Nfe2l1 protect cisplatin-induced acute kidney injury via suppressing ACSL4-dependent ferroptosis [0.03%]
肾小管Nrf1通过抑制ACSL4依赖性铁死亡来保护顺铂诱导的急性肾脏损伤
Jianqiang Hu,Yuewei Zhang,Yan Zhang et al.
Jianqiang Hu et al.
Introduction: Nfe2l1 is a transcription factor that is highly conserved and is encoded by the Nuclear Factor Erythroid 2 Like 1 (Nfe2l1) gene, which responds to oxidative stress, proteotoxic stress, and endoplasmic reticu...
Microplastics induce osteoarthritis by modulating chondrocyte inflammation and disrupting TGF-β signaling in mesenchymal stem cells [0.03%]
微塑料通过调节软骨细胞炎症并干扰间充质干细胞中TGF-β信号传导来诱导骨关节炎
Kainong Sun,Shuting Zhou,Meng Yang et al.
Kainong Sun et al.
Introduction: Microplastics (MPs) are pervasive pollutants that can accumulate in the human body through the food chain. Osteoarthritis (OA) is the most common degenerative joint disease with an increasing prevalence due ...
CsZAT6/12 response auxin signaling to differentially regulate theanine-dominated nitrogen flow in tea roots (Camellia sinensis) [0.03%]
-CsZAT6/12响应生长素信号差异性调节茶树根系氮流向茶氨酸合成-
Maoyin Fu,Dongqiao Zheng,Huanhuan Zong et al.
Maoyin Fu et al.
Introduction: L-theanine, a nitrogen compound uniquely synthesized in tea plant roots, is a core determinant of tea flavor and a key carrier for nitrogen. Its metabolic dynamics are tightly linked to root development, yet...
Low temperatures enhance PM2.5-mediated mitochondrial dysfunction in the pig lung-intestinal axis, causing damage to the gut [0.03%]
低温通过猪肺肠轴增强PM2.5介导的线粒体功能障碍导致肠道损伤
Jianing Tu,Shuyu Zhang,Weichen Hong et al.
Jianing Tu et al.
Introduction: Fine particulate matter (PM2.5) is a major airborne pollutant in low-temperature livestock housing. Individual environmental factors have been widely studied. However, the actual growth environments of lives...
Metabolic reprogramming in endometriosis: mechanisms and therapeutic prospects [0.03%]
子宫内膜异位症的代谢重构：机制和治疗前景
Cuishan Guo,Xinni Na,Zechen Guo et al.
Cuishan Guo et al.
Background: Endometriosis (EMS) is an estrogen-dependent chronic inflammatory disorder for which metabolic reprogramming has emerged as a central pathological feature. Driven by genetic, epigenetic, and microenvironmental...
When robots become one of us: Moral evaluation and neural processing of community norm violations by in-group robots [0.03%]
当机器人成为我们的一员：道德评价和神经处理社区规范违规行为的类机器人内群体成员现象
Yue He,Yaner Su,Zhibo Yang et al.
Yue He et al.
Introduction: As robots become increasingly integrated into human social life, it is important to understand how people morally evaluate their violations of community norms-norms related to group interests and cohesion-es...