FGFs/FGFRs and neuroinflammatory diseases: mechanism, drug therapies and delivery systems [0.03%]
FGFs/FGFRs与神经炎症性疾病：机制、药物治疗及递送系统
Juan Wang,Lijuan Xing,Song Yang et al.
Juan Wang et al.
Background: Fibroblast Growth Factors and Fibroblast Growth Factor Receptors (FGFs/FGFRs) constitute a complex and diverse signaling system crucial in various biological processes, such as cell proliferation, differentiat...
Targeting post-translational modifications: novel insights into bone metabolic diseases [0.03%]
骨代谢疾病的蛋白质修饰调控新机制研究进展
Hui Kong,Juan-Juan Han,Guo Liang et al.
Hui Kong et al.
Background: Bone metabolic diseases constitute a group of disorders characterized by abnormal alterations in bone mass and skeletal metabolism, often resulting from oxidative stress, nutritional deficiencies, and various ...
Ion interference induced by Ca-Mn nanoplatform enhances ferroptosis and promotes immune response for osteosarcoma treatment [0.03%]
锰钙纳米平台诱导的离子干扰增强铁死亡并促进免疫反应以治疗骨肉瘤
Minyi Zhang,Qi Wang,Chen Li et al.
Minyi Zhang et al.
Introduction: Ion interference therapy has emerged as a promising new treatment for Osteosarcoma (OS). However, its efficacy is significantly restricted by inadequate hydrogen peroxide (H2O2) under the complex tumor micro...
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs [0.03%]
ATP感应的嘌呤受体P2rx7介导的骨衰老预防机制通过调节MSC中的线粒体活性起作用
Zimeng Zhuang,Chunshan Han,Meilian Cai et al.
Zimeng Zhuang et al.
Background: Bone aging, displays osteoporosis and impaired bone formation, intricately linked to the metabolic alteration of mesenchymal stem cells (MSCs). However, the precise mechanisms underlying this relationship rema...
Deciphering molecular pathways in urological cancers: a gateway to precision therapeutics [0.03%]
解码泌尿系统癌症分子通路：精准治疗的突破口
Kiavash Hushmandi,Najma Farahani,Behzad Einollahi et al.
Kiavash Hushmandi et al.
Background: Urological cancers, including prostate, kidney, bladder, testicular, and penile cancers, pose a significant health challenge, particularly in their metastatic stages. Surgical interventions remain fundamental,...
Cholesterol metabolism-related characteristics predict response and survival in esophageal cancer [0.03%]
胆固醇代谢相关特征预测食管癌的疗效和生存率
Lingyu Tan,Xiaodong Su,Yuanzhen Ma et al.
Lingyu Tan et al.
Introduction: Cholesterol homeostasis has been identified as an essential downstream pathway of mutations in TP53. Esophageal cancer is one of the most prevalent malignancies exhibiting the mutation. ...
Cytoskeletal-related genes function as checkpoints for the maintenance of VSMC contractile phenotype and prevent pathological remodeling in arterial diseases [0.03%]
细胞骨架相关基因可作为血管平滑肌细胞收缩表型维持的检查点并在动脉疾病病理重塑中发挥作用
Yunchang Liu 刘运畅,Liping Zeng 曾利平,Qi Cai 蔡琦 et al.
Yunchang Liu 刘运畅 et al.
Introduction: Arterial pathological remodeling, central to arterial diseases including atherosclerosis and aortic aneurysms, is characterized by vascular smooth muscle cell (VSMC) phenotypic switching with concomitant los...
Integrative multi-omics profiling deciphers tumor microenvironment heterogeneity and immunotherapy vulnerabilities in lung neuroendocrine carcinomas [0.03%]
整合多组学谱分析解码肺神经内分泌癌的肿瘤微环境异质性和免疫治疗弱点
Zicheng Zhang,Modi Zhai,Siqi Bao et al.
Zicheng Zhang et al.
Introduction: Lung neuroendocrine carcinomas (Lu-NECs) are rare, highly aggressive lung tumors with poor prognosis and limited therapeutic options. Understanding the tumor immune microenvironment (TIME) is crucial towards...
SAE1 emerges as a pan-cancer driver and key regulator of HCC metastasis [0.03%]
SAE1作为泛癌症驱动基因和肝细胞癌转移的关键调节因子浮现出来
Hao Zhuang,Yamei Dang,Li Sun et al.
Hao Zhuang et al.
Introduction: Dysregulation of SUMOylation is implicated in cancer progression. While the role of SUMO-activating enzyme (SAE) and its mechanisms in cancer remain unclear. ...
A novel peptide MIB1-223aa encoded by exosomal circMIB1 from cancer-associated fibroblasts drives triple-negative breast cancer metastasis and stemness via stabilizing MIB1 to activate Notch signaling [0.03%]
癌相关成纤维细胞来源的环状circMIB1衍生的小分子多肽MIB1-223aa通过稳定MIB1蛋白激活Notch信号驱动三阴性乳腺癌干细胞特性及转移的功能研究
Fangzhou Ye,Yiran Liang,Jianing Wang et al.
Fangzhou Ye et al.
Introduction: Emerging evidence has indicated that the complex interactions between tumor microenvironment (TME) and cancer cells play a pivotal role in driving tumor initiation and metastasis. Cancer associated fibroblas...