Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation [0.03%]
槲皮素通过AKT/NF-κB/NLRP3介导的线粒体自噬激活来缓解肌腱干细胞衰老并促进老年肌腱修复
Hao Wang,Yu-Cheng Gao,Ming-Zhang et al.
Hao Wang et al.
Introduction: Aged tendon exhibits impaired regenerative capacity due to the accumulation of senescent tendon stem/progenitor cells (TSPCs), which secrete senescence-associated secretory phenotype (SASP) factors and displ...
RNA-m5C regulatory atlas of human fetal tissues uncover the activities of Nsun2/Jarid2/Alyref axis [0.03%]
人类胎儿组织中的RNA-m5C调控图谱揭示Nsun2/Jarid2/Alyref轴的活性
Xiujuan Hu,Chenyue Ding,Jiafeng Lu et al.
Xiujuan Hu et al.
Introduction: Cytosine methylation (m5C) is a pivotal RNA modification essential for human fetal development, yet its tissue-specific distribution and regulatory mechanisms remain largely undefined. ...
Xi-Xi Xiang,Qing-Chang Xia,Xiao-Bin Zhang et al.
Xi-Xi Xiang et al.
Introduction: Drugs entitled polymeric network special functions in bio-applications. However, the introduction of appropriate solvent for drugs generally incurred tedious inclusion methods, intensive chemical design and ...
Epigenetically silenced KAT2B suppresses de novo lipogenesis through destroying HDAC5/LSD1 complex assembly in renal cell carcinoma [0.03%]
表观遗传沉默的KAT2B通过破坏HDAC5/LSD1复合物组装抑制肾细胞癌中的从头脂质合成
Qi Wang,Daojia Miao,Ruijie Liu et al.
Qi Wang et al.
Introduction: Renal cell carcinoma (RCC) is a common cancer that seriously threatens human health. Advanced RCC is characterized by poor responsiveness to radiotherapy and chemotherapy, with targeted therapy and immunothe...
Oral natural extracellular vesicles for biomedical applications: Advances and clinical perspectives [0.03%]
口腔来源的天然外泌体及其生物医学应用研究进展与临床前景展望
Xiaoru Guan,Mingzhang Zhu,Huinan Zhu et al.
Xiaoru Guan et al.
Background: Natural extracellular vesicles (EVs) are nanoscale vesicles derived from diverse biological sources, recognized for their roles in intercellular communication and therapeutic cargo delivery. Due to their intri...
Longitudinal prediction of drug response in high-grade serous ovarian cancer organoid cultures aligning with clinical responses [0.03%]
类器官共培养纵向预测高级别浆液性卵巢癌的药物反应并与临床反应一致
Enrico Cavarzerani,Isabella Caligiuri,Michele Bartoletti et al.
Enrico Cavarzerani et al.
Introduction: High-grade serous ovarian cancer (HGSOC) ranks among the most aggressive gynecological malignancies. Its high mortality is driven by frequent recurrence after primary treatments and the development of platin...
Innovative applications of multidimensional engineered hydrogels in wound healing [0.03%]
用于伤口愈合的多功能工程水凝胶的创新应用
Min Hu,Qiaoyan Zhang,Luping Qin
Min Hu
Background: The skin, as the largest organ of the human body, functions as a critical protective barrier against external threats such as pathogens, mechanical damage, and temperature extremes while regulating physiologic...
Clonal haematopoiesis is associated with protection against angina pectoris in the UK population [0.03%]
克隆性血细胞形成与英国人群胸痛保护相关
Yidan Zheng,Zihao Zhou,Xingyu Qian et al.
Yidan Zheng et al.
Introduction: Clonal haematopoiesis of indeterminate potential (CHIP) has been reported to increase the risk of various diseases, including cardiovascular diseases (CVDs). In contrast, a newly published study suggests tha...
Emerging host-directed strategies for overcoming drug resistance and immune evasion in Staphylococcus aureus infections [0.03%]
克服金黄色葡萄球菌感染中耐药性和免疫逃避的新型宿主导向策略
Youle Zheng,Jin Feng,Qianwei Qu et al.
Youle Zheng et al.
Background: Staphylococcus aureus poses a significant global threat to both human and animal health. Bacterial-targeted therapies are limited by strong selective pressures (e.g., mecA-mediated β-lactam resistance) and th...
Intelligent microfluidic device for multiplex detection and prompt warning of upper and lower respiratory tract infections [0.03%]
一种用于多重检测和上下呼吸道感染预警的智能微流控设备
Shijue Gao,Lei Wang,Meng Zhao et al.
Shijue Gao et al.
Introduction: The increasing incidence and co-infection rates of multiple respiratory diseases have emphasized the necessity for efficient and reliable multiplex diagnostic methods for respiratory pathogens. ...