Blockade of calcium-activated chloride channel ANO1 ameliorates ionizing radiation-induced intestinal injury [0.03%]
氯通道ANO1的阻断改善电离辐射引起的肠损伤
Yuying Guo,Tong Yuan,Yuna Wang et al.
Yuying Guo et al.
Introduction: Radiation enteritis is one of the most frequent clinical complications of radiotherapy (RT), yet few effective strategies currently exist to protect against that. Anoctamin 1 (ANO1) functions both as a chlor...
When glycobiology meets inflammasome activation: Insights and implications [0.03%]
糖生物学与炎性小体活化研究的见解和意义
Hongliang Zhang,Tengchuan Jin,Mengzhou Xue et al.
Hongliang Zhang et al.
Background: Glycobiology focuses mainly on the study of glycan structures and their biological functions. Glycans not only provide a basic energy supply through the tricarboxylic acid cycle and glycolysis but also serve a...
Global, regional, and national burden of neglected tropical diseases and malaria in the general population, 1990-2021: Systematic analysis of the global burden of disease study 2021 [0.03%]
1990年至2021年全球、区域和国家各类热带病和疟疾疾病负担：基于《2021年全球疾病负担研究》的系统分析
Jin-Xin Zheng,Yang Liu,Shi-Yang Guan et al.
Jin-Xin Zheng et al.
Background: Neglected Tropical Diseases (NTDs) and malaria present considerable health obstacles, particularly impacting the socio-economic progress in at-risk areas. We aimed to estimate the burden, trends, and inequalit...
The LoMYB26/LoJAZ4-LoCOMT module regulates anther dehiscence via Jasmonic acid-mediated endothecium lignification in lily [0.03%]
番红花素通过茉莉酸介导的内表皮木质化调节药用百合花粉散发
Qianqian Fang,Xue Pan,Ze Wu et al.
Qianqian Fang et al.
Introduction: Timely anther dehiscence is a key step for successful sexual reproduction in plants. Secondary cell wall thickening of anther endothecium is a vital process during anther dehiscence that provides an indispen...
Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research [0.03%]
一种用于加速转化研究的全人胶质母细胞瘤脑类器官模型的发展
Sandra Horschitz,Ammar Jabali,Sophie Heuer et al.
Sandra Horschitz et al.
Introduction: Glioblastoma (GBM) progression and therapeutic resistance are significantly influenced by complex interactions between tumor cells and the brain microenvironment, particularly neurons. However, studying thes...
Screening, identification and detection of the regulated and emerging mycotoxins in edible and medicinal products by integrating diversiform liquid chromatography/mass spectrometry systems and high-throughput sequencing of contaminated fungi [0.03%]
整合多种形式液相色谱/质谱系统和高通量测序真菌技术对食药产品中受控和新出现的霉毒素进行筛选、识别及检测
Xiao-Yan Xu,Yu Wang,Lian-Xing Wang et al.
Xiao-Yan Xu et al.
Introduction: Safety issues pertaining to mycotoxin contamination of the edible and medicinal products (EMPs) have attracted significant attention. EMPs not only have high nutritional values, but also exert valuable medic...
Senkyunolide A interrupts TRAF6-HDAC3 interaction to epigenetically suppress c-MYC and attenuate cholestatic liver injury [0.03%]
senkyunolide A干扰TRAF6-HDAC3相互作用以表观遗传抑制c-MYC和减轻胆汁淤积性肝损伤
Yajing Li,Runping Liu,Jianan Li et al.
Yajing Li et al.
Introduction Cholestatic liver diseases are highly prevalent and lack effective treatment, ultimately progressing to end-stage liver diseases. Our recent study indicates that the interplay between c-MYC and lncRNA H19 exacerbates the ductul...
Natural, safety immunomodulatory derivatives of lactobacillus biofilms promote diabetic wound healing by metabolically regulating macrophage phenotype and alleviating local inflammation [0.03%]
天然乳酸菌生物膜免疫调节衍生代谢物通过调节巨噬细胞表型和缓解局部炎症促进糖尿病伤口愈合
Qingwei Zhou,Junjie Chi,Jintao Yang et al.
Qingwei Zhou et al.
Introduction: Long-term inflammatory microenvironment further impairs the healing process of diabetic wounds. Many studies have shown that Lactobacillus can regulate immune function and promote injured tissue repair. Howe...
Development and validation of a deep learning model based on cascade mask regional convolutional neural network to noninvasively and accurately identify human round spermatids [0.03%]
基于级联掩码区域卷积神经网络的深度学习模型的发展和验证，以非侵入性且准确地识别人类圆形精子细胞
Yujiao Sun,Shihao Shao,Jiangwei Huang et al.
Yujiao Sun et al.
Introduction: The difficulty of identifying human round spermatids (hRSs) has impeded applications of the human round spermatid injection (ROSI) technique. RSs can be accurately screened through flow cytometric analysis u...
Lipidomic signatures as predictive biomarkers for early-onset lung cancer: Identification and development of a risk prediction model [0.03%]
脂质组标志物作为早期肺癌预测生物标志物的识别及风险预测模型的建立
Fei Wang,Zeming Guo,Wei Tang et al.
Fei Wang et al.
Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. While traditionally associated with older adults, early-onset lung cancer (EOLC) is rising, particularly in Asia, which accounts for 75...