Shikonin nasal spray film preparation promoted the repair of nasal mucosal injury by the interaction of shikonin with interleukin-6 [0.03%]
漆酚鼻喷雾膜促进通过与白细胞介素-6相互作用修复鼻粘膜损伤
Tao Gao,Qingye Jiang,Bin Zhang et al.
Tao Gao et al.
Introduction: Nasal spray films, an innovative formulation in recent years, have garnered significant acclaim from patients with nasal mucosal injury because it integrate the benefits of spray and film formulation, offeri...
Dietary n-3 polyunsaturated fatty acids intervention ameliorates cognitive dysfunction in db/db mice by mitigating cortical insulin resistance, mitochondrial dysfunction, and energy metabolism impairment [0.03%]
饮食中的n-3多不饱和脂肪酸干预通过减轻皮质胰岛素抵抗、线粒体功能障碍和能量代谢障碍来改善db/db小鼠的认知功能障碍
Yu Liu,Xiaojun Ma,Jingjing Xu et al.
Yu Liu et al.
Introduction: Cognitive dysfunction is a prevalent complication associated with Type 2 Diabetes Mellitus (T2DM). Cognitive dysfunction in patients with T2DM not only severely impacts their quality of life but also imposes...
Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization [0.03%]
乳酸菌约翰逊菌源性细胞外囊泡携带GAPDH通过调节巨噬细胞极化来抵抗溃疡性结肠炎
Shiyu Tao,Mengzhen Song,Jinping Fan et al.
Shiyu Tao et al.
Introduction: Ulcerative colitis (UC) is a major inflammatory condition worldwide. Objectives: The purpose of this study was to investi...
S-sulfhydration: Novel insights into the antioxidant and antiinflammation in age-related diseases [0.03%]
S-硫化作用：年龄相关疾病抗氧化和抗炎的新见解
Fei Liu,Lan Li,Longhui Yuan et al.
Fei Liu et al.
Background: Hydrogen sulfide (H2S) and hydrogen polysulfide-induced S-sulfhydration are critical posttranslational modifications that specifically target cysteine residues within proteins. Degenerative diseases are often ...
Three-dimensional multimodal imaging for predicting early recurrence of hepatocellular carcinoma after surgical resection [0.03%]
三维多模态影像预测肝癌手术切除后早期复发的研究
Jie Peng,Jiaren Wang,Hongbo Zhu et al.
Jie Peng et al.
Background: High tumor recurrence after surgery remains a significant challenge in managing hepatocellular carcinoma (HCC). We aimed to construct a multimodal model to forecast the early recurrence of HCC after surgical r...
Root-derived low molecular weight organic acids modulate keystone microbial taxa impacting plant phosphorus acquisition [0.03%]
根系来源的低分子量有机酸调节关键微生物类群以影响植物磷素吸收
Jie Zheng,Guangping Shi,Francisco Dini-Andreote et al.
Jie Zheng et al.
Introduction: Low-molecular-weight organic acids (LMWOAs) present in root exudates modulate the assembly and function of phosphorus (P)-mobilizing bacteria in the rhizosphere. Nonetheless, relatively little is known about...
Probiotics and triglyceride manipulation: potential implications for alleviating hypertriglyceridemia [0.03%]
益生菌与甘油三酯调节：对缓解高甘油三酯血症的潜在影响
Mingliang Zhang,Weimin Jiang,Jie Yin et al.
Mingliang Zhang et al.
Background: Hypertriglyceridemia is one of the most prevalent lipid abnormalities encountered in clinical practice. Although many monogenic disorders causing severe hypertriglyceridemia have been identified, in most patie...
Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments [0.03%]
Nr4a1年龄依赖性升高通过抑制PI3K / AKT / GSK3β通路介导tau过度磷酸化和认知障碍
Ling Lei,Qian Guo,Yilei Cheng et al.
Ling Lei et al.
Introduction: Tau hyperphosphorylation exhibited in Alzheimer's brains is also commonly observed in aging process, however, the molecular mechanism underlying tau hyperphosphorylation in aging is largely unknown. The nucl...
GhGLDH35A gene-mediated ROS homeostasis and stomatal movement via the ascorbic acid pathway confers alkaline stress tolerance [0.03%]
通过抗坏血酸途径介导的GhGLDH35A基因ROS稳态和气孔运动以提高耐碱性
Yapeng Fan,Ning Wang,Shuai Wang et al.
Yapeng Fan et al.
Introduction: Ascorbic acid (AsA) is involved in plant responses to various abiotic stresses. However, its specific function in alkaline stress tolerance remains poorly understood. The L-galactono-1,4-lactone dehydrogenas...
Mesenchymal stem cell transplantation alleviated TBI-induced lung injury by inhibiting PAD4-dependent NET formation [0.03%]
间充质干细胞移植通过抑制PAD4依赖性的NET形成缓解创伤性脑损伤引起的肺损伤
Jing Peng,Fengming Pan,Yu Xu et al.
Jing Peng et al.
Introduction: Traumatic brain injury (TBI) affects millions of people worldwide and often results in significant extracranial complications, particularly acute respiratory distress syndrome (ARDS). The mechanisms underlyi...