Gastrodin enhances stress resilience through promoting Wnt/β-Catenin-Dependent neurogenesis [0.03%]
gastrodin通过促进Wnt/β-catenin依赖性神经发生来增强压力耐受性
Haili Zhang,Zhihuang Zhao,Pei Liu et al.
Haili Zhang et al.
Background: Enhancing stress resilience constitutes a pivotal strategy in mitigating the risk of depression, making it a critical component of both prevention and treatment. In the current work, we identified a compound, ...
Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial networks via tryptophan metabolism and AHR-Nrf2 signaling [0.03%]
通过色氨酸代谢和AHR-Nrf2信号调节肠道微生物网络，芽孢杆菌thetaiotaomicron成为腹泻的共生盟友
Yuheng Luo,Cong Lan,Wen Ren et al.
Yuheng Luo et al.
Introduction: Bacteroides is a crucial mucosal symbiotic bacterium in mammals, with Bacteroides thetaiotaomicron (B. thetaiotaomicron) being particularly noteworthy as a glyco-specialist due to its significant nutritional...
Comparative single-cell transcriptomic map reveals divergence in leaves between two cotton species at cell type resolution [0.03%]
单细胞转录组图谱揭示了两种棉种叶片细胞类型的差异性
Hailiang Cheng,Shang Liu,Youping Zhang et al.
Hailiang Cheng et al.
Introduction: Leaves are important functional organs in plants that determine yield and quality of crop. Upland cotton and sea-island cotton contribute more than 90% of the cotton fiber production annually. Deciphering an...
MRI-based radiomics to determine the role of thigh muscle quality in the development of knee osteoarthritis: A discovery and validation study [0.03%]
基于MRI的影像组学确定股四头肌质量在膝骨关节炎发病中的作用：一项发现与验证研究
Qin Dang,Zixuan Hong,Dong Zeng et al.
Qin Dang et al.
Introduction: Although the reduced muscle quality is common in elderly people, its role in the development of knee osteoarthritis (OA) remains unclear. Magnetic Resonance Imaging (MRI) is considered the gold standard imag...
Integrated deep eutectic system enrichment and AI-assisted high-throughput visual detection for Hg2+ in environmental samples [0.03%]
基于集成深共熔体系富集和AI辅助的高通量视觉识别的环境样品中Hg2+检测方法研究
Yilin Peng,Kunze Du,Hengmao Yue et al.
Yilin Peng et al.
Introduction: Mercury ion (Hg2+), a prevalent heavy metal, is commonly found in environmental soil and water. Its interaction with sulfhydryl groups in proteins or lipids can cause oxidative stress and disrupt calcium hom...
Engineered 3D mesenchymal stem cell aggregates with multifunctional prowess for bone regeneration: Current status and future prospects [0.03%]
具有多效性的工程化三维间充质干细胞聚合体促进骨再生：现状与未来展望
Linxue Zhang,Xiaojing Yuan,Rui Song et al.
Linxue Zhang et al.
Background: Impaired efficacy of in vitro expanded mesenchymal stem cells (MSCs) is a universal and thorny situation, which cast a shadow on further clinical translation of exogenous MSCs. Moreover, the relatively lengthy...
TMEM158 promotes ICC metastasis via inducing lactic acid mediated reduction of actin skeleton stiffness of ICC cells [0.03%]
TMEM158通过诱导乳酸介导的ICC细胞肌动蛋白骨架刚度降低促进ICC转移
Peng Chen,Jing Yang,Shengxi Jin et al.
Peng Chen et al.
Introduction: The survival rate of patients with intrahepatic cholangiocarcinoma (ICC) is extremely low mainly because of its high metastatic characteristic, pushing us to explore effective targets inhibiting the metastas...
ARHGEF3 coordinates adipocyte hypertrophy and differentiation through dual YAP-RhoA and PPARγ activation [0.03%]
ARHGEF3通过双重YAP-RhoA和PPARγ活化协调脂肪细胞肥大和分化
Sana Abdul Khaliq,Shi-Young Park,Syeda Maham et al.
Sana Abdul Khaliq et al.
Introduction: Obesity presents a significant global health burden, necessitating insights into the molecular drivers of adipogenesis and adipose tissue regulation. ...
Hang Xu,Meng Wu,Yujian Wang et al.
Hang Xu et al.
Introduction: Gasdermin (GSDM) is a family of proteins that execute pyroptosis after being activated by caspase (CASP) cleavage. Mammals possess five GSDM members (A - E) with pyroptotic ability. Teleosts possess only one...
Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion [0.03%]
炎症驱动的类生物纳米多酚药物递送系统通过抑制巨噬细胞PANoptosis和胰腺酶过分泌来缓解急性重症胰腺炎
Junyong Wu,Hai Huang,Wenjie Xu et al.
Junyong Wu et al.
Introduction: Severe acute pancreatitis (SAP) is a critical inflammatory disease with high morbidity and mortality. Current treatments focused on symptomatic relief but failed to prevent inflammation progression in cellul...