Breaking the bottleneck of asthma treatment: the future of omni-targeted therapy [0.03%]
突破哮喘治疗瓶颈：全方位靶向治疗的未来方向
Kuan Li,Huimin Xie,Dongshuai Shen et al.
Kuan Li et al.
Background: Bronchial asthma is a complex, highly heterogeneous disease involving multiple pathological mechanisms and inflammatory pathways. Traditional pharmacotherapies, including glucocorticoids, leukotriene modifiers...
A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory [0.03%]
腹侧海马-基底外侧杏仁核环路调节远程恐惧记忆的未条件刺激提取诱导再巩固作用
Dan Guo,Zhong Wang,Fanglin Liu et al.
Dan Guo et al.
Introduction: Memory is retrieved and updated during reconsolidation, which provides a potential target for therapeutic intervention. Reconsolidation blockade following unconditioned stimulus (US) retrieval has shown incr...
Beyond chromosomes: exploring the diverse functions of extrachromosomal circular DNA [0.03%]
染色体之外：探究染色体外环状DNA的多种功能
Yaling Chen,Jian Wang,Xudong Liu et al.
Yaling Chen et al.
Extrachromosomal circular DNA (eccDNA) is defined as a form of circular DNA that is widespread across various biological contexts and exists independently of chromosomal structures. The current distribution of total eccDNA identified in bot...
MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis [0.03%]
MK8722通过激活Sesn2并转录上调BNIP3促进线粒体自噬和抑制软骨细胞铁死亡从而缓解骨关节炎
Haochen Wang,Ze Zhao,Jianbang Su et al.
Haochen Wang et al.
Introduction: Osteoarthritis (OA) is commonly accompanied by irreversible destruction of articular cartilage and is difficult to effectively relieve, primarily due to the unclear pathogenesis and the lack of effective the...
Bacteroides vulgatus alleviates heart failure via butyric acid-TGF-β1/MAPK pathway [0.03%]
脆弱拟杆菌通过丁酸盐-TGF-β1/MAPK信号通路缓解心力衰竭
Zhiyong Du,Wenxin Zhang,Yu Wang et al.
Zhiyong Du et al.
Introduction: The gut microbiota plays a vital role in the progression of heart failure (HF), making it a potential strategy for treating HF. The Bacteroides genus has shown promising potential for treating HF. However, f...
Rural-urban disparities in cardiovascular and other competing risk of death among cancer patients [0.03%]
癌症患者中心血管疾病及其他总死亡竞争风险的城乡差异
Tianwang Guan,Jiaqi He,Liangjia Zeng et al.
Tianwang Guan et al.
Introduction: Rural-urban disparity of cancer is a major public health problem, with an unclear gap in noncancer death. It is important to evaluate rural-urban disparities in cardiovascular diseases (CVDs) and other compe...
Mitigation of renal tubular injury by SIRT6 may improve individual outcomes in diabetic kidney disease-potential mechanisms involving epigenetic repression of inflammatory responses [0.03%]
SIRT6通过表观遗传抑制炎症反应可能改善糖尿病肾病的肾小管损伤及患者预后-潜在机制研究
Qi Jin,Lanfang Li,Peng Qu et al.
Qi Jin et al.
Introduction: Progressive tubulointerstitial injury plays a critical role in the progression of diabetic kidney disease (DKD), but the epigenetic mechanisms driving this process remain largely unclear. ...
Navel orange postharvest resistance towards Penicillium digitatum - role of histone demethylase CsJMJ12 [0.03%]
CsJMJ12 去甲基酶在调控柠檬组蛋白修饰及提高柠檬对绿霉病抗性中的作用机制研究
Jing Zeng,Ting Li,Mengting Liu et al.
Jing Zeng et al.
Introduction: Histone methylation is essential for plant growth and development, and adaptation to biotic and abiotic stresses. However, its role in postharvest disease resistance in fruits remains poorly understood. The ...
Lactylation: a promising target for musculoskeletal disorders via interactions with chronic inflammation [0.03%]
乳酰化通过与慢性炎症相互作用成为治疗肌肉骨骼疾病的新靶点
Tiantian Wang,Sihan Chen,Zhen Hong
Tiantian Wang
Musculoskeletal disorders (MSDs) encompass conditions that affect bones, joints, and muscles, leading to substantial pain and functional impairment and representing a major global health concern. In MSDs, key metabolic processes-such as gly...
Corrigendum to "Erianin serves as an NFATc1 inhibitor to prevent breast cancer-induced osteoclastogenesis and bone destruction" Adv. Res. 69 (2025) 399-411] [0.03%]
“姜黄素通过抑制NFATC1的活性防止乳腺癌诱发破骨细胞生成和骨破坏”的勘误(Adv.Res.69(2025)399-411)
Jiehuang Zheng,Weili He,Yan Chen et al.
Jiehuang Zheng et al.