From energy metabolism to mood regulation: The rise of lactate as a therapeutic target [0.03%]
从能量代谢到情绪调节：乳酸作为治疗靶点的崛起
Sen Zhang,Jie Xia,Wenke He et al.
Sen Zhang et al.
Background: Disruption of cerebral energy metabolism is increasingly recognized as a key factor in the pathophysiology of mood disorders. Lactate, beyond its role as a metabolic byproduct, is now understood to be a critic...
Prophylactic supplementation with biogenic selenium nanoparticles mitigated intestinal barrier oxidative damage through suppressing epithelial-immune crosstalk with gut-on-a-chip [0.03%]
生物源硒纳米粒子预防性补充通过肠道芯片上皮-免疫互作抑制缓解肠屏障氧化损伤
Lei Qiao,Ge Yang,Tianjing Deng et al.
Lei Qiao et al.
Introduction: Biogenic selenium nanoparticles (SeNPs) have emerged as novel promising modulators of biological reactions such as redox and immune responses due to their multiple bioactivities and unique physicochemical pr...
Astragaloside II, a natural saponin, facilitates remyelination in demyelination neurological diseases via p75NTR receptor mediated β-catenin/Id2/MBP signaling axis in oligodendrocyte precursor cells [0.03%]
Astragaloside Ⅱ通过p75NTR介导的β-catenin/Id2/MBP信号轴促进少突胶质前体细胞在脱髓鞘疾病中的修复作用
Jinfeng Yuan,Yanlin Tao,Mengxue Wang et al.
Jinfeng Yuan et al.
Background: Demyelination is a hallmark of neurological disorders such as multiple sclerosis and neuromyelitis optica, leading to neurological deficits. Existing therapies primarily modulate immune responses but lack effi...
Long read and preliminary pangenome analyses reveal breed-specific structural variations and novel sequences in Holstein and Jersey cattle [0.03%]
长读和初步的泛基因组分析揭示了荷斯坦牛和Jersey牛中特定品种的结构变异及新颖序列
Yahui Gao,Liu Yang,Kristen Kuhn et al.
Yahui Gao et al.
Introduction: Most SV studies in livestock rely on short-read sequencing, posing challenges in accurately characterizing large genomic variants due to their limited read length. ...
Resibufogenin protects against atherosclerosis in ApoE-/- mice through blocking NLRP3 inflammasome assembly [0.03%]
树脂苷素通过阻断NLRP3炎性小体组装保护动脉粥样硬化Apoe基因敲除小鼠模型
Chen Xiaoyang,Chen Yijun,Zhai Chenguang et al.
Chen Xiaoyang et al.
Introduction: Atherosclerosis (AS), a major cause of cardiovascular diseases, is characterized by lipid accumulation and chronic inflammation within arterial walls. Traditional treatments, such as statins, are often ineff...
Urate-lowering effect of delphinidin-3-glucoside in red kidney beans via binding to the FAD site of the XO enzyme [0.03%]
飞燕草素-3-葡萄糖苷通过与黄嘌呤氧化酶的FAD结合位点结合抑制尿酸生成作用机制研究
Yanling Chen,Yingtong Jiang,Lei Huang et al.
Yanling Chen et al.
Background: The incidence of hyperuricemia (HUA) is increasing globally, posing serious health risks. The discovery of natural urate-lowering agents is urgently needed. ...
Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer's disease [0.03%]
杜仲叶多糖通过重塑肠道菌群改善阿尔茨海默病学习记忆障碍的作用及机制研究
Yongkang Zhao,Wenxing Zhao,Xuejun Chai et al.
Yongkang Zhao et al.
Background: Alzheimer's disease (AD), which is a chronic neurodegenerative disorder, is marked by the progressive deteriorations in learning and memory capabilities. The microbiota-gut-brain axis has come to be regarded a...
Design, synthesis and activity evaluation of dual-target inhibitors against papain-like and main proteases of porcine epidemic diarrhea virus [0.03%]
猪流行性腹泻病毒半胱氨酸蛋白酶和主要蛋白酶双靶点抑制剂的设计、合成及活性评价
Jiashu Chen,Yuxi Lin,Chenxia Gao et al.
Jiashu Chen et al.
Introduction: Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), threatens the global pig industry due to lack of drugs. PEDV replication relies on PLpro and Mpro, which are crucial targets...
Medical gas plasma modifies Nrf2 signaling in diabetic wound healing [0.03%]
医学等离子体对糖尿病伤口愈合中Nrf2信号传导的调节作用
Anke Schmidt,Lea Miebach,Can Bagli et al.
Anke Schmidt et al.
Introduction: Diabetes mellitus is a chronic disease that can disrupt physiologic wound healing. Medical gas plasma technology produces therapeutic reactive species that support wound healing. ...
Pulsed electromagnetic fields treatment ameliorates cardiac function after myocardial infarction in mice and pigs [0.03%]
脉冲电磁场治疗可改善小鼠和猪心肌梗死后的心脏功能
Shiqi Wang,Gaiqin Pei,Jiayu Shen et al.
Shiqi Wang et al.
Introduction: Ischemic heart disease (IHD) is a prominent contributor to mortality worldwide, with myocardial infarction (MI) representing its most severe manifestation. Pulsed electromagnetic fields (PEMF) treatment show...