HDAC2 enhances the antimicrobial activity of neutrophils by promoting the formation of neutrophil extracellular traps (NETs) in sepsis [0.03%]
组蛋白去乙酰化酶2通过促进脓毒症中性粒细胞胞外陷阱的形成增强其抗菌活性
Zhan Li,Wang Hu,Kaiyan Lv et al.
Zhan Li et al.
Introduction: Sepsis is characterized as a life-threatening organ dysfunction resulting from a dysregulated host response to infection, representing a critical clinical syndrome. Uncontrolled infection and inflammation ar...
Synthetic microbial communities rescues strawberry from soil-borne disease by enhancing soil functional microbial abundance and multifunctionality [0.03%]
合成微生物组增强土壤功能菌丰度和多功能性从而拯救感染土传病害的草莓植株
Guoshen Lei,Zhixiang Han,Xingyue Wang et al.
Guoshen Lei et al.
Introduction: Synthetic microbial communities (SynCom) contribute to mitigating soil-borne crop diseases while enhancing both crop quality and yield. However, relatively little research has been done on the intricate regu...
Computational discovery and repurposing of chloramphenicol succinate as a potent P2Y14 receptor antagonist for inflammatory bowel disease therapy [0.03%]
计算发现和再定位氯霉素琥珀酸盐作为炎症性肠病治疗的强效P2Y14受体拮抗剂
Sheng Tian,Kai Wang,Chunxiao Liu et al.
Sheng Tian et al.
Introduction: The P2Y14 receptor (P2Y14R), a Gi-coupled receptor activated by UDP-glucose, plays a critical role in inflammatory responses and immune regulation. Existing P2Y14R antagonists face limitations such as poor b...
Long noncoding RNA Nron and its functional motif modulate macrophage-mediated inflammatory response [0.03%]
长非编码RNA Nron及其功能基序调节巨噬细胞介导的炎症反应
Liuye Yang,Pengchao Wang,Kaiyuan Liu et al.
Liuye Yang et al.
Introduction: Non-resolving macrophage-mediated inflammation is closely linked to the pathogenesis of systemic inflammatory response syndrome. Despite years of clinical trials attempting to mitigate the harmful effects of...
The gut-tumor connection: the role of microbiota in cancer progression and treatment strategies [0.03%]
肠道-肿瘤关联：微生物群在癌症进展与治疗策略中的作用
Ziqing Wei,Guangqi Gao,Qiuwen He et al.
Ziqing Wei et al.
Background: The tumor microenvironment (TME) has become a critical focus in the diagnosis and treatment of cancer. The involvement of the microbiome in tumor initiation and progression underscores its potential as a promi...
Flexible wearable medical devices: from material innovations and data processing to intelligent healthcare applications [0.03%]
灵活的可穿戴医疗设备：从材料创新和数据处理到智能医疗应用
Junxi Zhou,Qingbo Zhang,Ming Zhang et al.
Junxi Zhou et al.
Background: Flexible wearable medical devices drive healthcare transformation via non-invasive, real-time physiological monitoring and personalized management. Traditional rigid devices lack long-term comfort, while chron...
Application of machine learning and deep learning in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis [0.03%]
机器学习和深度学习在代谢功能异常相关脂肪性肝病中的应用：系统回顾和荟萃分析
Huan Zhang,Xiangyu Wu,Wenjing Ni et al.
Huan Zhang et al.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) can progress to metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, contributing to a heavier global health burden. No...
Research progress and therapeutic strategies in hepatocellular carcinoma metabolic reprogramming [0.03%]
肝细胞癌代谢重编程的研究进展与治疗策略
Haibo Wang,Yu Lun,Dongdong Xu et al.
Haibo Wang et al.
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with therapeutic resistance posing a significant clinical challenge. Metabolic reprogramming, a hallmark of cancer,...
The role of induced resistance in mitigating postharvest fungal diseases in fruits and vegetables [0.03%]
诱导抗性在果蔬产后真菌病害防控中的作用研究进展
Yuan Sui,Zhen Li,Xianmei Xiao et al.
Yuan Sui et al.
Background: The process of fruit ripening after harvest renders them susceptible to water loss and disease development by fungal pathogens. Postharvest fungal diseases compromise produce quality and reduce marketable yiel...
Serum uric acid and its metabolism-a vital factor in the inflammatory transformation of cancer [0.03%]
血清尿酸及其代谢-癌症炎性转化的关键因素
Zongping Li,Yingyu Su,Hang Su et al.
Zongping Li et al.
Background: Uric acid (UA) is the terminal product of purine metabolism. Elevated serum uric acid (SUA) levels, resulting from excessive synthesis or impaired excretion, are link to chronic inflammatory stress and increas...