Modulation of Macrophage ferroptosis under the guide of infrared thermography promotes the healing of pressure injuries [0.03%]
红外热图引导巨噬细胞铁死亡调控促进压伤愈合
Xiaoqiong Jiang,Xuanlong Zhang,Huiming Deng et al.
Xiaoqiong Jiang et al.
Background: Accurately recognizing and regulating the transition time of macrophages to a pro- (M1-like) or anti-inflammatory (M2-like) state is essential for improving chronic inflammation in pressure injuries (PIs). ...
Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition [0.03%]
发育内皮定位基因1通过抑制Cmpk2-cGAS-STING通路并促进修复性巨噬细胞转化来促进肠道炎症消退
Meihui Tao,Li Wang,Chaoyue Chen et al.
Meihui Tao et al.
Introduction: Abnormalities in inflammation resolution function are intimately linked to chronic inflammation, and proresolution therapies may offer novel opportunities for IBD treatment. Developmental endothelial locus 1...
Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells [0.03%]
CircularRNA circATM通过结合PARP1抑制Wnt/β-catenin信号通路并诱导胃癌细胞周期停滞
Xiaohui Zhu,Xiaojing Zhang,Ying Qin et al.
Xiaohui Zhu et al.
Introduction: Gastric cancer (GC) is a common malignancy, which is associated with high rates of morbidity and mortality. Despite therapeutic advancements, there is an overall lack of effective treatment options for patie...
CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB [0.03%]
Circular RNA CircPAFAH1B2通过结合分子伴侣ClpB诱导软骨细胞线粒体功能障碍并促进软骨退变
YuFan Bu,Chang Zhao,Yewen Qian et al.
YuFan Bu et al.
Introduction: This study explores the role of circPAFAH1B2 in osteoarthritis (OA) by investigating its influence on nuclear-mitochondrial communication, a largely unexplored area in OA progression. By uncovering how circP...
Chaperone-mediated autophagy sustains pericyte stemness necessary for brain tissue homeostasis [0.03%]
伴侣介导的自噬维持脑组织稳态所需周细胞干细胞性质
Maria Dolores Salinas,Carlos M Martínez,Francisco J Roca et al.
Maria Dolores Salinas et al.
Introduction: Pericytes (PCs) are mural cells exhibiting some mesenchymal stem cell (MSC) properties and contribute to tissue regeneration after injury. We have previously shown that glioblastoma cancer cells induce in PC...
JAK3-deficient mimi-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production [0.03%]
JAK3缺陷型微型猪表现出淋巴器官发生、肠道结构以及白细胞/细胞因子产生的异常
Pil-Soo Jeong,Hae-Jun Yang,Young-Ho Park et al.
Pil-Soo Jeong et al.
Introduction: Severe combined immunodeficiency (SCID) mini-pigs are a highly versatile model for human disease research and regenerative medicine. Objecti...
A novel CRISPR-Cas9 nickase-mediated rolling circle amplification (CRIRCA) technique for gene identification and quantitative analysis of extrachromosomal DNA [0.03%]
一种新型的CRISPR-Cas9切口酶介导的滚环扩增技术(CRIRCA)，用于基因鉴定和染色体外DNA的定量分析
Yuchen Song,Chaoyang Guan,Yue Zhang et al.
Yuchen Song et al.
Introduction: Extrachromosomal DNA (ecDNA) plays an important role in the initiation and progression of cancerous tumors. Although Circle-seq and other genetic technologies can be utilized for ecDNA analysis, they fail to...
miR398-SlCSD1 module participates in the SA-H2O2 amplifying feedback loop in Solanum lycopersicum [0.03%]
miR398-SlCSD1模块参与了番茄的水杨酸-H2O2放大反馈环路
Xiujuan Wang,Xinshan Zhang,Yuanyuan Liu et al.
Xiujuan Wang et al.
Introduction: Salicylic acid (SA) is essential for immune response signal transduction in higher plants, with its signaling thought to be enhanced through interactions with reactive oxygen species (ROS). However, the exac...
A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization [0.03%]
一种新型TGR5激动剂白花前胡素通过调节巨噬细胞极化改善咪喹莫特诱导的小鼠银屑病
Hao-Yu Wang,Su-Ling Huang,Jing Ren et al.
Hao-Yu Wang et al.
Introduction: G-protein-coupled bile acid receptor (TGR5) is a member of G-protein-coupled receptor (GPCR) superfamily that participates in regulating macrophage polarization and resolving inflammatory diseases. Sauchinon...
Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models [0.03%]
尼克地米延长健康寿命并减少衰老模型的衰弱表型通过改善mTORC1过度活化所致的影响
Pyeong Geun Choi,Hee Soo Kim,So-Hyun Park et al.
Pyeong Geun Choi et al.
Introduction: Frailty is characterized by an increased vulnerability to disease and physical debilitation due to a decline in the body's capacity to maintain homeostasis during aging. Therefore, effective management of fr...