Regulation of apocarotenoids for quality improvement and biofortification of horticultural crops [0.03%]
利用 apo- 类类胡萝卜素改善园艺作物品质及营养强化的研究进展
Lihong Liu,Yuening Li,Chunxia Jian et al.
Lihong Liu et al.
Background: Agro-food production and consumption impact climate change and human health. Bioactive secondary metabolites in horticulture crops make them an indispensable part of environmentally sustainable and healthy die...
Construction of safer hirudin-derived peptides with enhanced anticoagulant properties based on C-terminal active residue adaptation and modification [0.03%]
基于C端活性残基适应性和改良的更具抗凝血功效的安全的新涎素肽类化合物的构建
Xiaozhe Yi,Xiaoli Wu,Erhuan Zang et al.
Xiaozhe Yi et al.
Introduction: Hirudin exerts anticoagulant effects by inhibiting the binding and catalytic activity of thrombin to fibrinogen. However, its rigid N-terminal region irreversibly occupies the thrombin catalytic center, rais...
Statistical agnostic regression: A machine learning method to validate regression models [0.03%]
统计无偏回归：一种验证回归模型的机器学习方法
J M Gorriz,J Ramirez,F Segovia et al.
J M Gorriz et al.
Introduction: Regression analysis is a central topic in statistical modeling, aimed at estimating the relationships between a dependent variable, commonly referred to as the response variable, and one or more independent ...
AMPCliff: Quantitative definition and benchmarking of activity cliffs in antimicrobial peptides [0.03%]
基于抗菌肽的活性悬崖的定量定义及基准测试
Kewei Li,Yuqian Wu,Yinheng Li et al.
Kewei Li et al.
Introduction: Activity cliff (AC) is a phenomenon that a pair of similar molecules differ by a small structural alternation but exhibit a large difference in their biochemical activities. This phenomenon affects various t...
Dual effects of vaginal Candida albicans on human papillomavirus infection: A large-scale multicenter study in Chinese women [0.03%]
白色念珠菌的阴道感染对人乳头瘤病毒感染的双重影响：中国女性的大规模多中心研究
Muxuan Chen,Rongdan Chen,Yingxuan Zhang et al.
Muxuan Chen et al.
Objectives: Vaginal infections caused by Candida albicans and human papillomavirus (HPV) are common, yet their interactions remain complex and poorly understood. ...
Suppressing wheat sucrose phosphate synthase 1-B protects wheat against stripe rust [0.03%]
抑制小麦蔗糖磷酸合成酶1-B可保护小麦抵御条锈病
Yan Yan,Meng-Lu Wang,Zhen Zhang et al.
Yan Yan et al.
Introduction: Stripe rust caused by Puccinia striiformis Westend. f. sp. tritici (Pst) is a highly destructive wheat disease that threatens global food security. Pst extracts energy from wheat by interfering with photosyn...
Electromagnetic fields regulate iron metabolism: From mechanisms to applications [0.03%]
电磁场调节铁代谢：从机制到应用
Shenghang Wang,Jiancheng Yang,Chenxiao Zhen et al.
Shenghang Wang et al.
Background: Electromagnetic fields (EMFs), as a form of physical therapy, have been widely applied in biomedicine. Iron, the most abundant trace metal in living organisms, plays a critical role in various physiological pr...
Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus [0.03%]
脑脊液蛋白质组学揭示了特发性正常压力脑积水分流效果的生物标志物
Yuqi Ying,Jingquan Lin,Wei Gao et al.
Yuqi Ying et al.
Background: The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) remains unclear, and the treatment strategy remains suboptimal. This study aims to identify biomarkers for shunt prognosis by cerebrospina...
Nutritional and hormonal regulation of mitochondrial biogenesis drives fat body remodeling for reproductive competence [0.03%]
营养和激素调节线粒体生物发生以适应生殖反应脂肪体重塑
Yiying Li,Mengyao Lang,Qiongjie He et al.
Yiying Li et al.
Introduction: Insect fat body serves as a central hub for energy mobilization and protein synthesis. During larval metamorphosis, fat body undergoes programmed cell death and tissue disassembly. Following adult eclosion, ...
OTUD1 delays wound healing by regulating endothelial function and angiogenesis in diabetic mice [0.03%]
OTUD1通过调节糖尿病小鼠内皮细胞功能和血管生成来延缓伤口愈合
Jiajia Zhang,Weiqi Li,Yanan Liu et al.
Jiajia Zhang et al.
Introduction: Diabetic non-healing wounds represent a major complication of diabetes, primarily due to impaired angiogenesis. Ovarian tumor deubiquitinase 1 (OTUD1), a deubiquitinase, has been implicated in vascular patho...