Genetic modifications boost chrexanthomycin yield and neuroprotective potential [0.03%]
基因改良提高玉米素衍生物产量及其神经保护潜力
Wei Ye,Wenkang Ye,Xin Huang et al.
Wei Ye et al.
Introduction: Chrexanthomycins, a unique class of pentangular polyphenols (PPs) conjugated with glucuronic acid, have demonstrated remarkable neuroprotective properties both in vitro and in vivo. However, their low yield ...
Integrated metabolomic profiling of olive oil, olive mill wastewater, and pomace from Egyptian cultivars based on UHPLC-MS/MS and NMR coupled with chemometrics [0.03%]
基于UHPLC-MS/MS和NMR以及化学计量学的埃及橄榄品种特有代谢组综合轮廓分析：针对橄榄油、橄榄苦水和果渣的研究
Hamdy A Zahran,Shaimaa Fayez,Ahmed Zayed et al.
Hamdy A Zahran et al.
Introduction: Olive oil and their by-products have long been regarded as valuable sources of health-promoting metabolites. Although the composition of olive oil has been widely studied, less attention has been given to ol...
FSP1 reduces exogenous coenzyme Q10 and inhibits ferroptosis to alleviate intestinal ischemia-reperfusion injury [0.03%]
FSP1降低外源性辅酶Q10并抑制铁死亡以缓解肠缺血再灌注损伤
Tianli Shen,Xingjie Wang,Junxiang Zhang et al.
Tianli Shen et al.
Introduction: Intestinal ischemia-reperfusion injury (IRI) is a critical condition often requiring emergency intervention. Ferroptosis, a form of regulated cell death driven by phospholipid peroxidation, plays a central r...
FungiSNC: An integrated database for fungi small non-coding RNAs based on high-throughput sequencing [0.03%]
基于高通量测序的真菌小非编码RNA集成数据库FungiSNC
Xiaoqiang Lang,Jinjing Luo,Fazhi Li et al.
Xiaoqiang Lang et al.
Introduction: Small non-coding RNAs (sncRNAs) have been proven to play crucial roles in various biological processes such as development, stress responses, virulence, and pathogenicity. However, to the best of our knowled...
Tumour-specific delivery of ω-conotoxin MVIIA via engineered salmonella for safe anticancer therapy [0.03%]
工程肠炎沙门菌选择性递送ω-康诺毒素MVIIA用于安全有效的癌症治疗
Eunji Kim,Minju Han,Minchan Jeong et al.
Eunji Kim et al.
Introduction: Solid tumours present a significant treatment challenge owing to the poor penetration of therapeutics into the tumour core. Bacteria offer a unique solution to this problem because they can selectively targe...
Role of Netrin-1 dysregulation in early neuronal pathology of α-synuclein models of Parkinson's disease [0.03%]
神经调节蛋白-1失调在α-突触核蛋白帕金森病模型早期神经病理中的作用
Wenjing Han,Tiantian Wang,Ningping Tan et al.
Wenjing Han et al.
Introduction: Parkinson's disease (PD) is characterized by early synaptic and axonal dysfunction, driven by α-synuclein (α-Syn, encoded by the SNCA gene) aggregation. The axon guidance molecules play critical roles in n...
A novel genetic framework reveals transcriptional "butterfly effect" underlying heterosis in maize [0.03%]
一个新的遗传框架揭示了玉米杂种优势背后的转录“蝴蝶效应”
Yuhang Guo,Xiaohuan Lu,Dongdong Li et al.
Yuhang Guo et al.
Introduction: Maize is one of the first crops to benefit from heterosis, significantly enhancing commercial breeding. Despite extensive research, the molecular mechanisms of heterosis remain elusive. ...
Microbiome-mediated environmental adaptation in tea plants and its potential applications [0.03%]
茶树介导的环境适应及其潜在应用
Qianhong Pan,Jinglei Zheng,Hengtong Xie et al.
Qianhong Pan et al.
Background: The assembly of microbiomes during the growth and development of plants plays a crucial role in facilitating host adaptation by enhancing abiotic and biotic resilience to the adverse environment. Understanding...
Calpain-2 facilitates infection of the intracellular bacteria Listeria monocytogenes and invasion intestinal immune barrier by impairing nitric oxide homeostasis [0.03%]
钙蛋白酶-2通过破坏一氧化氮稳态促进单核细胞增生李斯特菌感染及肠道免疫屏障入侵
Bo Yao,Jingru Wang,Dingyu Hou et al.
Bo Yao et al.
Introduction: The ubiquitously expressed enzymes, calpain-1 and -2 (CAPN1 and 2) play important roles in a wide variety of physiological and pathological processes including infection and immune responses. CAPN2 is partic...
The therapeutic value of "Bile Transfer" for complications of acute pancreatitis: A retrospective clinical study [0.03%]
“胆转移”治疗急性胰腺炎并发症的疗效观察
Liang Zhang,Zijian Huang,Yusen Feng et al.
Liang Zhang et al.
Introduction: Acute pancreatitis (AP) is one of the most common gastrointestinal diseases, imposing a significant burden on patients, with its incidence steadily increasing worldwide. Despite a drop in fatality rates, AP-...