New insight into the role of SOCS family in immune regulation and autoimmune pathogenesis [0.03%]
细胞抑制素家族在免疫调节和自身免疫疾病中的作用机制的新见解
Shiyi Liu,Mingwei Wang,Liangjie Xu et al.
Shiyi Liu et al.
Background: Suppressor of cytokine signaling (SOCS) proteins regulate signal transduction by interacting with cytokine receptors and signaling proteins and targeting associated proteins for degradation. Recent studies hav...
Dynamic regulation and targeted interventions of macrophages in ischemia-reperfusion injury [0.03%]
缺血再灌注损伤中巨噬细胞的动态调控与靶向干预措施研究进展
Ping Lu,Ruotong Shen,Jingjing Yang et al.
Ping Lu et al.
Background: Ischemia-Reperfusion Injury (IRI) is a complex pathophysiological process characterized by oxidative stress and inflammatory responses during tissue reperfusion, leading to severe organ dysfunction. Macrophage...
TaPP2C-a5 fine-tunes wheat seed dormancy and germination with a Triticeae-specific, alternatively spliced transcript [0.03%]
TaPP2C-a5通过一个Triticeae特异的可选择性拼接转录本调节小麦种子休眠和萌发
Qian Zhang,Xiaofen Yu,Ya&#x;nan Wu et al.
Qian Zhang et al.
Introduction: The sessile plants often experience environmental conditions not ideal for growth, and therefore have evolved strategies to survive and adapt to stress conditions. Abscisic acid (ABA) regulates plant develop...
Basic mechanism of mobilizing cell movement during invasion of glioblastoma and target selection of targeted therapy [0.03%]
胶质母细胞瘤侵袭过程中动员细胞运动的基本机制及靶向治疗的靶点选择
Jie Xu,Pengfei Shi,Liqun Yang et al.
Jie Xu et al.
Background: Glioblastoma (GBM), also known as glioblastoma multiforme, is a rapidly growing and highly invasive malignant tumor. Due to the inability to clearly distinguish between glioblastoma and normal tissue, surgery ...
SA supplementation during lactation promotes learning and memory by reducing H3K27me3 levels [0.03%]
泌乳期沙棘叶提取物补充通过降低H3K27me3水平促进学习和记忆能力
Chengqing Huang,Shu Ai,Mengmeng Wang et al.
Chengqing Huang et al.
Introduction: Sialic acid (SA) is an essential nutrient for brain development and cognition. Infants lack the capacity to synthesize sufficient SA independently, requiring reliance on maternal or exogenous sources. For ea...
Heterologous expression of the barley-specific HvbZIP87 transcription factor in wheat enhances broad-spectrum disease resistance with balanced yield [0.03%]
barley特异的HvbZIP87转录因子在小麦中的异源表达可提高广谱抗病性并保持稳产水平
Shuqing Zhao,Ning Wang,Mengyu Li et al.
Shuqing Zhao et al.
Introduction: NPR1, a protein that interacts with bZIP transcription factors known as TGAs, plays a pivotal role in coordinating systemic acquired resistance (SAR) in plants. Nevertheless, the molecular intricacies govern...
Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis [0.03%]
基因组视角下的脂肪尾羊种群历史研究及两个促进脂肪尾形成的突变位点鉴定
Meilin Jin,Gang Liu,Enmin Liu et al.
Meilin Jin et al.
Introduction: Since their domestication, domestic sheep (Ovis aries) have been culturally and economically significant farming animals worldwide. Fat-tailed sheep serve as a unique genetic resource for understanding adipo...
Rab32-based vesicles coordinate mitochondria and actin for spindle migration and organelle rearrangement in oocyte meiosis [0.03%]
Rab32依赖囊泡调控卵母细胞减数分裂纺锤体迁移及线粒体重排的功能及机制研究
Hao-Lin Zhang,Qian Cui,Xiao-Ting Yu et al.
Hao-Lin Zhang et al.
Introduction: Rab32 is part of the Rab GTPase family, which is known as the regulator of vesicle transport for an array of cellular functions including endosomal transport, autophagy, generation of melanosomes, phagocytos...
PEBL, a component-based Chinese medicine, reduces virus-induced acute lung injury by targeting FXR to decrease ACE2 levels [0.03%]
靶向法尼醇受体降低ACE2表达的组分中药PEBL对病毒诱发急性肺损伤的作用研究
Liling Yang,Xiangjun Zhou,Junshan Liu et al.
Liling Yang et al.
Introduction: Despite the growing clinical need, the therapeutic efficacy of drugs for acute lung injury (ALI) remains inadequate. Traditional Chinese Medicine (TCM) holds potential in managing ALI due to its unique thera...
NRXN3 regulates pyroptosis in intrahepatic cholangiocarcinoma via mediating the phospho-dependent ubiquitination and degradation of caspase-3 [0.03%]
NRXN3通过介导磷酸化依赖性泛素化和降解Caspase-3来调节肝内胆管癌的焦亡作用
Tao Zhou,Yaodong Zhang,Tianlin Wang et al.
Tao Zhou et al.
Introduction: Intrahepatic cholangiocarcinoma (ICC) remains one of the most lethal malignancies with an increasing incidence worldwide. Gemcitabine has been considered the standard first-line chemotherapeutic agent for IC...