Discovery of natural RORγt inhibitor using machine learning, virtual screening, and in vivo validation [0.03%]
基于机器学习、计算机虚拟筛选和体内验证发现天然RORγt抑制剂
Hojin Yoo,Sang-Jun Han,Jeong-Eun Lee et al.
Hojin Yoo et al.
Introduction: Retinoic acid receptor-related orphan receptor gamma t (RORγt) is a crucial transcription factor regulating Th17 cells, which secrete the cytokine IL-17. RORγt inhibitors are regarded as a therapeutic moda...
Unraveling the nexus in the neuro-neoplastic progression of colorectal cancer: Potential role of β2-adrenergic receptor (β2-AR) [0.03%]
结直肠癌神经-肿瘤进展中神经-肿瘤轴的潜在联系：β2肾上腺素能受体（β2-AR）的潜在作用
Elizabeth Varghese,Samson Mathews Samuel,Slavomir Hornak et al.
Elizabeth Varghese et al.
Background: Studies on the interaction of cancer cells with other cells (fibroblasts, endothelial cells, and immune cells) of the tumor microenvironment (TME) have led to the development of many novel targeted therapies. ...
HDAC3 represses Nrf2-GDF11 signaling to drive chondrocyte adipogenesis in temporomandibular joint osteoarthritis [0.03%]
组蛋白脱乙酰酶3通过抑制Nrf2-GDF11信号促进颞下颌关节骨关节炎软骨细胞向脂肪生成分化
Yuqian Shi,Zhihua Xu,Fuyin Li et al.
Yuqian Shi et al.
Introduction: Aberrant biomechanical force-induced chondrocyte adipogenesis is involved in the development of temporomandibular joint osteoarthritis (TMJ OA). Growth differentiation factor 11 (GDF11) has been implicated i...
Reconstruction of three-dimensional fractures in coal based on multidirection slicing and U-Net segmentation [0.03%]
基于多方向切片和U-Net分割的煤岩三维节理裂隙重建
Yufeng Bian,Jiangtao Zheng,Tian Tian et al.
Yufeng Bian et al.
Introduction: Accurate characterization of multi-size fractures in coal is crucial for estimating its transport properties. However, the extraction of narrow microfractures in 3D voxel-type CT images is difficult, which c...
Genetic manipulation of OGT enhances NK cell-mediated cytotoxicity in tumor immunity [0.03%]
OGT的基因操作可增强NK细胞介导的肿瘤免疫毒性
Se-Chan Oh,Bong Chan Jeon,In-Hwan Jang et al.
Se-Chan Oh et al.
Introduction: Natural killer (NK) cells are essential effectors in immune surveillance and cancer immunotherapy, but their function is often compromised by metabolic stress and environmental factors within the tumor micro...
Beaver behavior optimizer: A novel metaheuristic algorithm for solar PV parameter identification and engineering problems [0.03%]
Beaver行为优化器：一种新颖的元启发式算法，用于太阳能PV参数识别和工程问题
Kaichen OuYang,Dedai Wei,Xinye Sha et al.
Kaichen OuYang et al.
Introduction: Numerical optimization plays a key role in improving the efficiency of solar photovoltaic (PV) systems and solving complex engineering problems. Traditional optimization methods often struggle with finding o...
Hepatotoxicity induced by polylactic acid microplastics: The mediating role of gut microbiota and uric acid metabolism [0.03%]
聚乳酸微塑料诱导的肝毒性：肠道微生物群和尿酸代谢介导的作用
Yanhong Deng,Zhiming Li,Yuji Huang et al.
Yanhong Deng et al.
Introduction: The increasing use of biodegradable plastics has led to the inevitable human consumption of biodegradable microplastics (MPs). These MPs can be degraded and absorbed into various organs and tissues via the g...
Tetramethylpyrazine improves the structure and function of mitochondrial-associated endoplasmic reticulum membrane and liver fibrosis [0.03%]
四氢吡咯酮改善线粒体相关内质网膜的结构和功能及肝纤维化
Kaihong Xie,Jianzhi Wu,Liping Gong et al.
Kaihong Xie et al.
Introduction: Morphological and functional abnormalities of mitochondrial-associated endoplasmic reticulum (ER) membrane (MAM) have emerged as a key mediator of organelle dysfunction during liver fibrosis. Tetramethylpyra...
Alginate oligosaccharides prevent and treat obesity by promoting brown fat thermogenesis rather than regulating gut microbiota [0.03%]
藻酸盐低聚糖通过促进棕色脂肪产热而不是调节肠道菌群来预防和治疗肥胖症
Yuncong Xu,Jun Jiang,Tao Li et al.
Yuncong Xu et al.
Introduction: Functional oligosaccharides may provide physiological benefits through several different mechanisms. However, the specific mechanisms of alginate oligosaccharides (AOSs) for the improvement of obesity remain...
Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells [0.03%]
铜离子载体复合物ES-Cu与芸香素协同作用，靶向FDX1，促进铜依赖性细胞死亡并逆转肝癌细胞仑伐替尼耐药性
Lu Yang,Peixian Pi,Mingzhu Zhang et al.
Lu Yang et al.
Introduction: Lenvatinib resistance remains a major challenge in hepatocellular carcinoma (HCC) treatment, highlighting the need for novel therapeutic strategies. Cuproptosis, a copper-dependent form of cell death, has be...