FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway [0.03%]
FGF21-FGFR1信号通过调节PINK1介导的线粒体自噬途径防治心脏肥大
Lei Chen,Lingxin Zheng,Yuan Qin et al.
Lei Chen et al.
Introduction: Cardiac hypertrophy is an independent risk factor and the primary predictor of heart failure (HF). Mitochondria are crucial for the shift from hypertrophy to heart failure. The expression of fibroblast growt...
Functional divergence of BnaWRKY7 homologs drives phytosterol variations in polyploid Brassica napus [0.03%]
雷蒙德氏基因渗入引起的油菜BnaWRKY7同源基因功能分化导致芸薹属植物甾醇含量变异
Xueyan Wang,Xuan Tian,Xiong Zhang et al.
Xueyan Wang et al.
Introduction: Gene duplication and subsequent functional divergence drive species evolution, adaptability, and biodiversity, particularly in polyploids. The polyploid Brassica napus has abundant phytosterols, which are cr...
Development and validation of an early diagnostic model to distinguish bacterial infection in patients with acute-on-chronic liver disease (AoCLD) and systemic inflammatory response syndrome (SIRS): a post-hoc analysis of a prospective multicenter cohort [0.03%]
急性-on-慢性肝病(AoCLD)合并全身炎症反应综合征(SIRS)患者细菌感染早期诊断模型的建立和验证：一项回顾性多中心队列研究
Hui Zhou,Hai Li,Guohong Deng et al.
Hui Zhou et al.
Background and objectives: Early differentiation between infectious and non-infectious systemic inflammatory response syndrome (SIRS) in patients with acute-on-chronic liver disease (AoCLD) remains challenging. This study...
Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis [0.03%]
单细胞和空间转录组分析揭示了vinculin介导的心脏流出道发育中的动态信号流动
Reeson Xu Wang,Mingxuan Liang,Xixin Wang et al.
Reeson Xu Wang et al.
Introduction: Cardiac outflow tract (OFT) development relies on the interactions among cardiac neural crest cells (CNCC) and the second heart field (SHF) cells. However, the molecular signals underlying these interactions...
Ginsenoside Rg3 inhibits melanoma progression by inducing ferroptosis via the p53/SLC7A11/GPX4 pathway [0.03%]
人参皂苷Rg3通过p53/SLC7A11/GPX4途径诱导铁死亡从而抑制黑色素瘤进展
Anting Ma,Shunyao Zhu,Xiaowen Yao et al.
Anting Ma et al.
Introduction: Melanoma represents an aggressive cutaneous malignancy with limited treatment options. Ginsenoside Rg3, an active component extracted from the roots of Panax ginseng, has been extensively demonstrated to pos...
The constitutive 20S proteasome is required for the maintenance and differentiation of spermatogonia in mice [0.03%]
组成型20S蛋白酶体对小鼠精原细胞的维持和分化是必需的
Anxuan Fang,Huiwen Cao,Ying Zhang et al.
Anxuan Fang et al.
Proteasomes undergo dynamic changes in their types and activities during mammalian spermatogenesis. While the spermatogenesis-specific 20S proteasome (s20S), characterized by PSMA8 substitution of PSMA7, is known to be essential for meiosis...
Independent component analysis deciphers the genetic basis of cotton fiber elongation through eQTLs and sQTLs [0.03%]
利用eQTL和sQTL独立成分分析解译棉纤维伸长的遗传基础
Mingjun Zhang,Lan Yang,Rui Liu et al.
Mingjun Zhang et al.
The formation of agronomic traits is regulated by a complex network consisting of transcriptional and post-transcriptional mechanisms. However, the coordination between these regulatory layers in cotton fiber elongation remains poorly under...
Decoding Regnase-1's role in skin inflammation: potential therapeutic implication for dermatological disorders [0.03%]
解码Regnase-1在皮肤炎症中的作用及皮肤病治疗的潜在意义
Sung Wook Kim,Kangwook Lee,Joo Young Lee et al.
Sung Wook Kim et al.
Background: Regnase-1 is a multifunctional regulatory protein involved in immune modulation and inflammatory processes. As an endoribonuclease, it degrades mRNAs encoding pro-inflammatory cytokines, including IL-1β and I...
scMapNet: Marker-based cell type annotation of scRNA-seq data via vision transfer learning with tabular-to-image transformations [0.03%]
基于视觉迁移学习的单细胞类型标记注释方法scMapNetBar chart
Zhe Yu,Ying Ye,Jianbo Pan
Zhe Yu
Introduction: Identifying cell types is a key step in single-cell RNA sequencing data analysis that aids in understanding cellular heterogeneity and facilitates downstream analyses such as those concerning cell-cell inter...
Development of a selectively AURKB targeting peptide degradation drug with artificial intelligence-assisted design for the treatment of acute lymphoblastic leukemia [0.03%]
人工智能辅助设计选择性靶向AURKB的肽降解剂治疗急性淋巴细胞白血病
Yun Xie,Hui Feng,Yinong Huang et al.
Yun Xie et al.
Introduction: Acute lymphoblastic leukemia (ALL) is a highly heterogeneous hematologic malignancy with poor prognosis in refractory and relapsed cases. Aurora kinase B (AURKB), a member of the Aurora kinase family, is mar...