Revealing the multiple faces of LRG1: gene expression, structure, function, and therapeutic potential [0.03%]
揭示LRG1的多面性：基因表达、结构、功能和治疗潜力
Ding Wang,Di Di,Bo Jiang et al.
Ding Wang et al.
Background: As the structural characterization of the Leucine-rich alpha-2-glycoprotein 1 (LRG1) protein progresses, its functional diversity has been increasingly unveiled, highlighting its clinical relevance in elucidat...
Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes [0.03%]
抗霉素A通过破坏嘧啶体的形成来抑制α疱疹病毒的复制
Yong-Qi Guo,Meng-Hang Wang,Ning Tang et al.
Yong-Qi Guo et al.
Introduction: Alpha-herpesvirus poses significant health risks to humans and challenges to animal husbandry. Currently, the clinically approved antiviral drug Acyclovir exhibits limitations, including drug resistance and ...
The functions of gut microbiota-mediated bile acid metabolism in intestinal immunity [0.03%]
肠道微生物群介导的胆汁酸代谢在肠免疫中的作用
Yanmin He,Weike Shaoyong,Yanli Chen et al.
Yanmin He et al.
Background: Bile acids, derived from cholesterol in the liver, consist a steroidal core. Primary bile acids and secondary bile acids metabolized by the gut microbiota make up the bile acid pool, which modulate nuclear hor...
SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations [0.03%]
SARS-CoV-2损伤心肌细胞线粒体与后遗症期心血管表现之间的关联
Wenliang Che,Shuai Guo,Yanqun Wang et al.
Wenliang Che et al.
Introduction: With the COVID-19 pandemic becoming endemic, vigilance for Long COVID-related cardiovascular issues remains essential, though their specific pathophysiology is largely unexplored. ...
Corrigendum to "Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages" [J. Adv. Res. 69 (2025) 125-138] [0.03%]
关于“腐植酸A通过激活肿瘤巨噬细胞中的TFEB介导的线粒体自噬来抑制乳腺癌进展”的勘误修正[原文发表于：J. Adv. Res. 69 (2025) 125-138]
Bowen Zheng,Yuying Wang,Baian Zhou et al.
Bowen Zheng et al.
Hyperoside modulates bile acid and fatty acid metabolism, presenting a potentially promising treatment for non-alcoholic fatty liver disease [0.03%]
hyperoside调节胆汁酸和脂肪酸代谢，可能是治疗非酒精性肝病的一种有前景的治疗方法
Songsong Wang,Qiang Jia,Xiaoli Liu et al.
Songsong Wang et al.
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial chronic condition that requires a systematic approach for effective management. Multi-effect therapeutic drugs derived from traditional Chinese m...
Palmitoylated COX-2Cys555 reprogramed mitochondrial metabolism in pyroptotic inflammatory injury in patients with post-acute COVID-19 syndrome [0.03%]
棕榈酰化的COX-2Cys555在急性后COVID-19综合征患者pyroptosis炎症损伤中的线粒体代谢重编程作用
Jia-Shen Wu,Chi-Yu Xu,Su-Min Mo et al.
Jia-Shen Wu et al.
Introduction: The complex interplay between protein palmitoylation, mitochondrial dynamics, and inflammatory responses plays a pivotal role in respiratory diseases. One significant features of post-acute coronavirus disea...
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis [0.03%]
PI3K/AKT/mTOR信号轴调控线粒体自噬和焦亡：椎间盘退变治疗靶点PTPN22的研究
Haibo Liang,Shu Yang,Yeheng Huang et al.
Haibo Liang et al.
Introduction: Intervertebral disc degeneration (IDD) is a predominant risk factor for low back pain (LBP). However, the mechanisms underlying IDD progression remain unclear. ...
Epigallocatechin gallate prevents and alleviates type 2 diabetes mellitus (T2DM) through gut microbiota and multi-organ interactions in Wistar healthy rats and GK T2DM rats [0.03%]
表没食子儿茶素没食子酸酯通过肠道菌群及多器官互作预防和缓解Wistar健康大鼠和GK2型糖尿病模型大鼠糖尿病 mellitus(T2DM)
Hongzhe Zeng,Changwei Liu,Liwei Wan et al.
Hongzhe Zeng et al.
Introduction: As the main active ingredient of the first FDA-approved phytochemical drug, epigallocatechin gallate (EGCG) can effectively alleviate glucolipid metabolic disorders. However, existing studies mainly focuses ...
Dynamic profiling of BMSC-dECM reveals accumulation of core matrisome proteins suppresses osteogenic differentiation and bone regeneration [0.03%]
动态分析BMSC-dECM揭示核心基质蛋白的积累抑制成骨分化和骨再生
Mei Li,Weilai Zhu,Mingyu Hu et al.
Mei Li et al.
Introduction: The extracellular matrix (ECM) of bone mesenchymal stem cells (BMSCs) plays a critical role in tissue development and regeneration. Rather than being inert, the ECM exhibits a dynamic structure that determin...