Disruption of PRC1 components RING1A and RING1B promotes angiogenesis via relieving BMP4 repression [0.03%]
PRC1组分RING1A和RING1B的失活通过解除对BMP4的抑制促进血管生成
Jingyuan Zhang,Xing Peng,Jinling Qin et al.
Jingyuan Zhang et al.
Introduction: Angiogenesis is crucial for tissue homeostasis and vascular regeneration following ischemia or injury. Epigenetic regulation has emerged as a key determinant of angiogenic gene expression. The Polycomb repre...
Bombyx mori Jun gene is involved in endoreplication of silk gland cells by regulating S-phase cell cycle genes [0.03%]
家蚕Jun基因通过调控S期细胞周期基因在家蚕丝腺细胞内参与DNA端复制过程
Peng Chen,Lanxing Wang,Yanbi Long et al.
Peng Chen et al.
Endoreplication as a variant of the cell cycle is an important avenue of development and reproduction for organisms. Endoreplication-induced polyploid cells are pivotal in ensuring the normal size and function of tissues and organs. However...
Reinforced immunotherapy of M1 macrophage-derived exosomes with CEL on TNBC via regulating macrophage functions [0.03%]
通过调节巨噬细胞功能利用CELO诱导的M1型巨噬细胞外泌体强化三阴性乳腺癌免疫治疗
Liuchunyang Yu,Xinyi Luo,Zhengjia Zhang et al.
Liuchunyang Yu et al.
Introduction: Triple-negative breast cancer (TNBC) demonstrates poor prognosis due to its heterogeneity-related biological barrier, immunosuppressive tumor microenvironment (TME) and escape of cancer cells on immune surve...
TRPA1-kinase axis polarization: Nepetalactone drives pest repulsion and predator attraction via divergent PKC/CaMKII signaling [0.03%]
TRPA1-激酶轴极化：香茅醇通过不同的PKC / CaMKII信号驱动害虫驱避和捕食者吸引
Jianying Li,Bo Wang,Yilin Wang et al.
Jianying Li et al.
Introduction: Nepetalactone, an iridoid compound derived from Nepeta cataria, is a potent TRPA1 agonist known to repel hematophagous insects. However, its ecological roles and molecular mechanisms within agricultural ecos...
Mitochondrial cardiovascular diseases: molecular mechanisms, multi-omics exploration and therapeutic strategies [0.03%]
线粒体心血管疾病：分子机制、多组学探索和治疗策略
Zhengyang Zhang,Xingwang Zhao,Xu Zhang et al.
Zhengyang Zhang et al.
Background: Recent research highlights that abnormal mitochondrial function is a key feature in several cardiovascular diseases (CVDs), including aortic dissection, aortic aneurysm, atherosclerosis, pulmonary hypertension...
Biomarkers for Alzheimer's disease across diverse biological domains: An umbrella review and evidence map [0.03%]
跨多个生物学领域的阿尔茨海默病生物标志物：伞式综述和证据地图
Jiseung Kang,Yejun Son,Yesol Yim et al.
Jiseung Kang et al.
Background: This study aimed to systematically assess the quality, biases, and credibility of associations between potential Alzheimer's disease (AD) biomarkers through an umbrella review of existing meta-analyses. ...
Organelle regulation of SUMOylation: regulatory mechanisms and therapeutic application [0.03%]
泛素连接酶对SUMO化修饰的调控：调控机制及应用研究
Menglin Gao,Xin Zhong,Kaisong Zhang et al.
Menglin Gao et al.
Background: SUMOylation is a pivotal post-translational modification (PTM) that has been extensively investigated in nuclear processes. However, its role in regulating suborganelle homeostasis warrants further exploration...
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1 [0.03%]
白芥硫化物通过直接靶向KEAP1的半胱氨酸434调节Nrf2和NF-κB / NLRP3炎症小体从而缓解慢性阻塞性肺疾病中的烟草烟雾损伤的作用及机制研究
Lin-Tao Xu,Qing-Tong Han,Zhen-Peng Xu et al.
Lin-Tao Xu et al.
Introduction: Chronic obstructive pulmonary disease (COPD) represents a significant global health challenge, characterized by substantial morbidity and mortality rates. In traditional Chinese medicine (TCM), Farfarae Flos...
Crafting an innovative one health-aligned machine learning framework for neglected tropical diseases elimination [0.03%]
一种创新的一体化机器学习框架在被忽视的热带病消除中的应用
Ziyu Zhao,Liying Wang,Robert Bergquist et al.
Ziyu Zhao et al.
Introduction: Strategic investment in new interventions is crucial for controlling and eliminating NTDs. However, selecting the optimal intervention combination is challenging, especially with limited resources and urgent...
Identification of Bruceine A as a novel HSP90AB1 inhibitor for suppressing hepatocellular carcinoma growth [0.03%]
布鲁欣A是一种新型HSP90AB1抑制剂可抑制肝癌细胞生长
Weijun Peng,Dazun Shi,Die Xu et al.
Weijun Peng et al.
Introduction: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with limited therapeutic options available. Natural compounds, such as Bruceine A (BRA), derived from Brucea java...