11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury [0.03%]
11-酮-β-羽扇豆醇酸和Z-姜黄素通过抑制HMGB1/TLR4通路活性重塑神经损伤后的相邻神经网
Yucheng Liao,Le Yang,Yi Ding et al.
Yucheng Liao et al.
Introduction: Remodeling of perineuronal nets is an emerging strategy for treating neuropathic pain (NP) and aligns with the traditional Chinese medicine concept of dispersing blood stasis dispersion and dredging collater...
Effects of general anesthetics on seizure termination, mortality, and neurological prognosis in a rat model of pediatric refractory status epilepticus: A comparative randomized controlled study [0.03%]
吸入麻醉药对儿童难治性癫痫持续状态大鼠模型痫性发作终止、死亡率及神经预后的比较随机对照研究
Bo Chen,Yuping Zhao,Na Shen et al.
Bo Chen et al.
Introduction: Refractory status epilepticus (RSE) is a serious neurological emergency in children associated with significant mortality and morbidity. General anesthetics (GAs) are routinely used to treat RSE. However, th...
UDP-glycosyltransferase confers anthranilic diamide resistance in Bemisia tabaci [0.03%]
褐飞虱对新烟碱类杀虫剂耐药性背后的UDP-葡萄糖基转移酶机制研究给棉铃虫带来除草剂酰胺类抗性的UDP葡萄糖基转移酶
Huiwen Tan,Xichao Hu,Jinghao Hu et al.
Huiwen Tan et al.
Introduction: UDP-glycosyltransferases (UGTs) are key Phase II detoxification enzymes in insects, playing a crucial role in resistance to a variety of insecticides, including diamides. Cyantraniliprole (CYA) is a systemic...
CXCR6 sustains TRM-driven psoriasis relapse by CXCL16 chemotaxis and curcumol targeting [0.03%]
趋化因子受体CXCR6通过趋化因子CXCL16驱动的效应T记忆干细胞复发并导致银屑病，而姜黄素类似物curcumol可以通过靶向抑制CXCR6来阻止该过程发生
Canbin Dong,Lianxi Sun,Yilun Wang et al.
Canbin Dong et al.
Introduction: Psoriasis is a chronic inflammatory skin disease characterized by a high relapse rate, primarily driven by tissue-resident memory T cells (TRM). ...
Tetrahedral framework nucleic acids: Nanokeys unlocking a new Era of precision biomedicine [0.03%]
四面体框架核酸：精准医学的纳米钥匙
Zhenhong He,Yi Liu,Yihuang Chen et al.
Zhenhong He et al.
Tetrahedral framework nucleic acids (tFNAs), a crucial component of DNA nanotechnology, have emerged as versatile tools in biomedical research largely attributed to their distinctive structural features and multifaceted capabilities. Recent...
IDR-driven LLPS of GAS2L3 scaffolds CHMP4B condensates to accelerate cytokinesis in hepatocellular carcinoma cells [0.03%]
GAS2L3通过IDR驱动的LLPS 架构CHMP4B凝聚物以加速肝细胞癌细胞的胞质分裂
Yan Zhao,Miao Zheng,Peiying Li et al.
Yan Zhao et al.
Introduction: Dysregulated cell cycle progression is a hallmark of cancer, promoting uncontrolled cell proliferation. Growth arrest-specific 2 like 3 (GAS2L3), which is highly expressed in hepatocellular carcinoma (HCC) c...
The effector AGLIP1 hijacks peroxidase OsAPX8 to coordinate rice immune suppression and ROS-Driven cell death for facilitating Rhizoctonia solani infection [0.03%]
效应蛋白AGLIP1劫持过氧化物酶OsAPX8来协调水稻免疫抑制和ROS驱动的细胞死亡以促进立枯丝核菌侵染
Zhuangyuan Fu,Junyi Ma,Bing Cao et al.
Zhuangyuan Fu et al.
Introduction: Necrotrophic fungi such as Rhizoctonia solani, the causal agent of rice sheath blight (RSB), release effectors that suppress host immune defenses and trigger host cell death. However, the molecular basis for...
PVA-based hydrogen-bonded supramolecular adhesive with core-shell nanoarchitectures for multifunctional and sustainable applications [0.03%]
具有核-壳纳米结构的基于PVA的氢键超分子多功能可持续性粘合剂
Zhen-Zhen Yin,Jia-Min Ma,Bin Zhao et al.
Zhen-Zhen Yin et al.
Introduction: Sustainable, high-performance adhesives are in high demand, yet their development is hindered by the trade-off between environmental friendliness and multifunctionality. Poly(vinyl alcohol) (PVA) offers a re...
Functional development of midbrain and pons during human gestation and electrophysiological markers for DS intervention [0.03%]
妊娠期间人脑桥和中脑的功能发育及唐氏综合征的电生理标志物
Yongkang Wu,Yingmei Fu,Hao Peng et al.
Yongkang Wu et al.
The early fetal period (GW8-20) is crucial for establishing motor and cognitive neural circuits. However, ethical constraints and limitations in current research methods have hindered our understanding of functional development in related b...
Sustainable tea plantations: Harnessing chemical-microbial synergy and smart application triangulation for targeted weed control [0.03%]
可持续茶树种植：化学-微生物协同作用及智能施用定位控制杂草
Lan Chen,Xiaolong Yang,Zhongzeng Su et al.
Lan Chen et al.
Background: Over 200 weed species-predominantly from the Poaceae and Asteraceae families-infest tea plantations. These weeds compete aggressively with tea plants for essential resources (light, water, and nutrients), serv...