Association between dietary amino acid intake and the risk of metabolic dysfunction-associated steatotic liver disease [0.03%]
膳食氨基酸摄入与代谢功能紊乱相关脂肪肝病风险的关系研究
Ruoqi Zhou,Xinrong Zhang,Xinxin Liu et al.
Ruoqi Zhou et al.
Introduction: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is becoming the major chronic liver disease, and diet plays crucial role in MASLD prevention. ...
Fe-S cluster deficiency drives small colony variant formation in persistent infections [0.03%]
缺铁诱导的硫铁簇缺陷驱动了持续性感染中的小菌落变异体的形成
Tianchi Chen,Zhiyi Ye,Weiyi Huang et al.
Tianchi Chen et al.
Introduction: Small colony variants (SCVs) of Staphylococcus aureus (S. aureus) are associated with persistent infections and poor clinical outcomes. The mechanisms driving stable SCV formation remain poorly understood, p...
Overexpression of soybean flavonoid 3'-hydroxylase enhances plant salt tolerance by promoting ascorbic acid biosynthesis [0.03%]
大豆黄酮3′-羟基酶的过表达通过促进抗坏血酸生物合成来增强植物耐盐性
Jianfei Wu,Xiaokun Wang,Jiawei Xu et al.
Jianfei Wu et al.
Introduction: Salt stress is a major cause of crop loss. Soybean (Glycine max), a globally vital legume crop, faces mounting yield constraints due to soil salinization. It is known that the flavonoid biosynthesis pathway ...
Mechanical mechanics-reclaiming a new battlefield for chronic liver disease [0.03%]
力学力学——为慢性肝病重新争取新的战场
Yiheng Zhang,Tianle Ma,XingXing Lu et al.
Yiheng Zhang et al.
Background: In the 21st century, significant breakthroughs have been made in the research of chronic liver disease. New biochemical markers of pathogenicity and corresponding drugs continue to emerge. However, current tre...
Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis [0.03%]
通过抑制TNF/CELSR2/p65/Kla-HDAC1/EPAS1轴靶向间充质单核细胞衍生的巨噬细胞以增强胶质母细胞瘤对替莫唑胺的敏感性
Wei Gao,Xinmiao Long,Xiang Lin et al.
Wei Gao et al.
Introduction: Temozolomide (TMZ) resistance poses a significant challenge to the treatment of aggressive and highly lethal glioblastomas (GBM). Monocyte-derived Macrophages (MDM) within the tumor microenvironment are key ...
Anthocyanin accumulation differences in European pears caused by Phytochrome-interacting factor 3 (PcPIF3) promoter mutations under UV-B [0.03%]
紫外辐射B介导的PcPIF3启动子突变引起欧洲梨花青素积累差异性增强响应机制研究
Haowei Cao,Yingying Qu,Lei Guo et al.
Haowei Cao et al.
The phenomenon of red fading in late-stage red-skinned pear fruit development significantly impacts its value. This phenomenon also occurs in 'Starkrimson', albeit to a lesser extent compared to 'Red Bartlett' and other varieties. The reaso...
NSP6 regulates calcium overload-induced autophagic cell death and is regulated by KLHL22-mediated ubiquitination [0.03%]
NSP6通过KLHL22介导的泛素化调控钙超载诱导的细胞自噬死亡
Xingyu Tao,Yanan Wang,Jiangbo Jin et al.
Xingyu Tao et al.
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a substantial global threat. SARS-CoV-2 nonstructural proteins (NSPs) are essential for impeding the host replication mechanism while also a...
An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of Notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1/Akt signaling [0.03%]
一种可注射的纳米羟基磷灰石掺杂水凝胶，通过Notch1/Akt信号通路促进血管生成，持续释放人参皂苷R1以增强骨再生
Bizhi Tan,Xiao Liu,Shuai Chen et al.
Bizhi Tan et al.
Introduction: Notoginsenoside R1 (NGR1), a bioactive compound, exhibits significant pro-angiogenic potential, making it a promising candidate for treating various diseases. Since angiogenesis and osteogenesis are synergis...
Osteoimmunity-Regulating biospun 3D silk scaffold for bone regeneration in critical-size defects [0.03%]
调控骨免疫的三维再生丝素蛋白支架促进临界尺寸骨缺损修复
Qian Zhang,Zulan Liu,YuanYuan He et al.
Qian Zhang et al.
Introduction: Silk-based biomaterials have received a great deal of attention in tissue engineering research for bone repair. Current silk-based materials are typically derived from silk protein solutions, but the limited...
Induction of cellular senescence by androgen receptor agonist or antagonist is mediated via two novel common DYRK1A-DREAM and cyclin G2 signaling pathways in castration-resistant prostate cancer [0.03%]
雄激素受体激动剂或拮抗剂通过两种新的共同DYRK1A-DREAM和cyclin G2信号通路在去势抵抗性前列腺癌中诱导细胞衰老
Golnaz Atri Roozbahani,Mehdi Heidari Horestani,Katrin Schindler et al.
Golnaz Atri Roozbahani et al.
Background: Castration-resistant prostate cancer (CRPC) is a deadly disease that in addition to being resistant to androgen deprivation often exhibits also resistant to androgen receptor (AR)-antagonists. Supraphysiologic...