The aryl hydrocarbon receptor inhibits antigen presentation to promote progression of pancreatic ductal adenocarcinoma [0.03%]
芳香烃受体通过抑制抗原呈递促进胰腺导管腺癌进展
Wentong Mei,Yixuan Ding,Chunjing Bian et al.
Wentong Mei et al.
Background: The aryl hydrocarbon receptor (AhR) plays a pivotal role in modulating immune responses and influencing tumor development by detecting metabolites derived from tryptophan breakdown. In patients suffering from ...
Targeting the muscle-brain axis to improve post-stroke cognition via the FNDC5/irisin/BDNF pathway [0.03%]
靶向肌肉-大脑轴通过FNDC5/鸢尾素/BDNF通路改善卒中后认知功能
Jiating Wei,Yuangui Cai,Zimu Jiang et al.
Jiating Wei et al.
Introduction: The muscle-brain axis involving FNDC5/irisin/BDNF supports brain health and cognition. Stroke often causes hemiplegic muscle atrophy, which may disrupt this axis and impair cognition. ...
RNAI-based strategies and nanomaterial-mediated delivery for green control of clubroot disease in rapeseed [0.03%]
基于RNA干扰策略和纳米材料介导传递的油菜根肿病绿色防控方法
Miaomiao Cui,Zanzan Xu,Zheng Shi et al.
Miaomiao Cui et al.
Introduction: Clubroot, caused by Plasmodiophora brassicae, threatens crucifers globally. RNAi shows promise for disease control, yet its use against clubroot is unexplored. ...
Pomegranate peel extract alleviates diabetic retinopathy by suppressing the PI3K/AKT/HIF-1α/VEGF pathway and gut microbiota modulation [0.03%]
石榴皮提取物通过抑制PI3K/AKT/HIF-1α/VEGF信号通路和调节肠道菌群改善糖尿病视网膜病变
Qi-Dong Ren,Mei-Rong Li,Mohamed A Farag et al.
Qi-Dong Ren et al.
Introduction: Diabetic retinopathy (DR) is a severe microvascular complication of diabetes mellitus. Pomegranate peel extract (PPE) has shown potential in mitigating various diabetic complications, yet its role in DR rema...
Norisoboldine restrains γδT17 cell activation and consequently alleviates psoriasis-like dermatitis in mice by selectively down-regulating glutaminolysis to decrease the level of α-ketoglutarate [0.03%]
norisoboldine通过选择性下调谷氨酰胺代谢来减少α-酮戊二酸的产生从而抑制小鼠γδT17细胞活化及类银屑病皮炎恶化的作用及机制研究
Yue He,Chenxi Li,Junchen Fan et al.
Yue He et al.
Introduction: Psoriasis, an inflammatory skin disease characterized by aberrant type 17 immunity, is effectively treated with monoclonal antibodies targeting IL-17, though with notable side effects. Given that γδT17 cel...
Clinical validation of a multi-model blood cfDNA methylation assay for early-stage gastrointestinal cancer screening [0.03%]
多模态血液cfDNA甲基化检测模型在早期胃肠道肿瘤筛查中的临床验证研究
Lingqin Zhu,Shuye Lin,Junfeng Xu et al.
Lingqin Zhu et al.
Background: Gastrointestinal (GI) tract cancers are the second leading cause of cancer-related mortality, often due to late detection. There is a critical need for non-invasive, highly sensitive biomarkers for early-stage...
Transcriptomics-driven antiviral drug screening identifies ATF6 as a homeostatic regulator of ER stress and innate immunity [0.03%]
基于转录组学的抗病毒药物筛选鉴定出ATF6是内质网应激和先天免疫的稳态调节因子
Zhenyu Yang,Jing Sun,Yan Zhao et al.
Zhenyu Yang et al.
Introduction: SARS-CoV-2 caused a global pandemic with widespread devastation on health system and many other aspects. Traditional drug development strategies have primarily focused on single targets in either the virus o...
MolProphecy: Bridging medicinal chemists' knowledge and molecular pre-trained models via a multi-modal framework [0.03%]
MolProphecy：通过多模态框架弥合药物化学家的知识与分子预训练模型之间的差距
Jianping Zhao,Qiong Zhou,Tian Wang et al.
Jianping Zhao et al.
Introduction: In drug discovery, the tacit domain knowledge of experts plays a critical role in guiding molecular design and decision-making.However, existing molecular pre-trained models rarely incorporate such expert kn...
Diagnostic and therapeutic potential of resolvin D1 in Guillain-Barré syndrome [0.03%]
脑脊髓炎诱发的吉兰-巴雷综合征中resolution D1诊断及治疗潜能研究
Ying Wang,Shan Liu,Mingqin Zhu et al.
Ying Wang et al.
Introduction: Most neuroimmune diseases are incurable and require lifelong immunotherapy, whereas Guillain-Barré syndrome (GBS), a peripheral nervous system autoimmune disorder, has a relatively favorable prognosis. Inve...
Characteristics of sediment sorting and sediment bound organic carbon loss during soil erosion under different soil organic carbon levels [0.03%]
不同土壤有机碳含量下土壤侵蚀过程中沉积物分选特征及吸附态有机碳损失特征
Ya Liu,Gang Liu,Ju Gu et al.
Ya Liu et al.
Introduction: Soil erosion-induced soil organic carbon (SOC) loss is a key driver of land degradation. SOC acts as both the target of loss and a key property influencing erosion processes. However, the mechanisms through ...