Maternal exposure to urban particulate matter induces cardiac developmental toxicity in zebrafish offspring by disrupting mitochondrial homeostasis [0.03%]
暴露于微粒污染物的母体通过扰乱线粒体稳态诱导斑马鱼后代心脏发育毒性
Shiqian Liu,Ruiyang Ding,Linyuan Huang et al.
Shiqian Liu et al.
Introduction: Urban particulate matter (UPM) is a major air pollutant affecting public health, with maternal exposure potentially leading to cardiac developmental disorders in offspring. However, the exact mechanisms unde...
Aroma compounds with enhanced sweet perception in tea infusions: Screening, characterization, and sweetening mechanism [0.03%]
具有增强甜感的茶汤香气成分筛选、表征及增甜机制研究
Yuming Wei,Ya-Ya Yu,Yuan-Chao Li et al.
Yuming Wei et al.
Introduction: Tea (Camellia sinensis) is globally consumed for its pleasant flavor, with sweetness being a key factor in evaluating tea quality. While taste compounds contribute to this sweetness, aroma also plays a signi...
Ketogenic diet and β-hydroxybutyrate inhibit HDAC1 to preserve vascular smooth muscle cell function in thoracic aortic aneurysm [0.03%]
生酮饮食和β-羟基丁酸通过抑制HDAC1来保持胸主动脉瘤血管平滑肌细胞的功能
Xinyu Weng,Lihong Pan,Xiurui Ma et al.
Xinyu Weng et al.
Background: Thoracic aortic aneurysm (TAA) is a serious condition characterized by dilation of the thoracic aorta, often leading to aortic dissection or rupture. Current treatments involve surgical and pharmacological int...
JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway [0.03%]
JAM-C通过抑制TAZ/KLF6途径预防眼部纤维化
Min Chen,Wanhong Li,Yuxiang Du et al.
Min Chen et al.
Introduction: Ocular fibrosis is one of the leading causes of irreversible visual impairment or blindness. Currently, there is no effective drug available for such diseases. Therefore, understanding the underlying mechani...
Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis [0.03%]
芽孢杆菌及其代谢产物通过调节巨噬细胞极化对抗痛风性关节炎
Siyue Song,Kaiyue Shi,Moqi Fan et al.
Siyue Song et al.
Introduction: Gut microbiota modulation has recently been identified as a prospective avenue for the exploration of novel therapeutic strategies for the management of gout. Nevertheless, the application of a single specif...
Multi-omics analysis of glycolytic reprogramming and ROS dynamics in host-specific responses to Salmonella Typhi infection in mice [0.03%]
小鼠宿主特异性响应伤寒沙门氏菌感染的糖酵解重构及活性氧动态的多组学分析
Yanrui Bai,Wenxiu Liu,Zhiyuan Liu et al.
Yanrui Bai et al.
Introduction: Salmonella Typhi (S. Typhi), a Gram-negative, serves as the etiological agent of typhoid fever. In contrast to other Salmonella serovars, S. Typhi exclusively infects humans. However, the molecular interacti...
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer [0.03%]
血红素氧合酶1（HO-1）是逆转非小细胞肺癌顺铂耐药的药物靶点
Jie Mei,Hui-Xiang Tian,Xiao-Ye Zhang et al.
Jie Mei et al.
Introduction: Platinum-based drugs, the most widely used chemotherapeutic drugs in clinical oncology, have long faced the problem of drug resistance, which is urgently in need of resolution. Identifying biomarkers of drug...
Beyond the Brain: Exploring the multi-organ axes in Parkinson's disease pathogenesis [0.03%]
超越大脑：探索帕金森病发病机制中的多器官轴
Tingting Liu,Haojie Wu,Jianshe Wei
Tingting Liu
Background: Parkinson's Disease (PD), a complex neurodegenerative disorder, is increasingly recognized as a systemic condition involving multi-organ interactions. Emerging evidence highlights roles of organ-brain axes (lu...
Novel function of macrophage migration inhibitory factor in regulating post-infarct inflammation and the therapeutic significance [0.03%]
巨噬细胞迁移抑制因子调控心梗后炎症的新型功能及其治疗学意义
Ling Zhao,Guo-Li Du,Amanguli Ruze et al.
Ling Zhao et al.
Introduction: Recent studies indicate that macrophage migration inhibitory factor (MIF) has a dual role in myocardial infarction (MI), with different cellular sources of MIF influencing inflammation and healing differenti...
Trends, patterns, and risk factors of esophageal cancer mortality in China, 2008-2021: A national mortality Surveillance System data analysis [0.03%]
中国食管癌死亡率的流行趋势、模式和危险因素（2008—2021年）：全国死因监测系统数据的分析研究
Yunfei Jiao,Tinglu Wang,Lin Fu et al.
Yunfei Jiao et al.
Introduction: According to the International Agency for Research on Cancer, China had the highest mortality burden of esophageal cancer (EC) globally in 2022. ...