IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms [0.03%]
IQGAP3与前列腺癌相关：潜在病理机制的详细阐述
Wenjuan Mei,Ying Dong,Yan Gu et al.
Wenjuan Mei et al.
Introduction: IQGAP3 possesses oncogenic actions; its impact on prostate cancer (PC) remains unclear. Objective: We will investigate IQ...
Inflammasomes cross-talk with lymphocytes to connect the innate and adaptive immune response [0.03%]
炎性小体通过与淋巴细胞交叉对话连接先天和适应性免疫反应
Hongliang Zhang,Jie Gao,Yujie Tang et al.
Hongliang Zhang et al.
Background: Innate and adaptive immunity are two different parts of the immune system that have different characteristics and work together to provide immune protection. Inflammasomes are a major part of the innate immune...
Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss [0.03%]
Obacunone通过作用于巨噬细胞迁移抑制因子(MIF)来阻碍破骨细胞的形成并缓解卵巢切除引起的骨质流失
Jianbo He,Lin Zheng,Xiaojuan Li et al.
Jianbo He et al.
Introduction: Osteoporosis is the most common bone disorder where the hyperactive osteoclasts represent the leading role during the pathogenesis. Targeting hyperactive osteoclasts is currently the primary therapeutic stra...
Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells? [0.03%]
阿尔茨海默病和突触丢失：从诱导多能干细胞我们能学到什么？
Francisco Javier Rodriguez-Jimenez,Juan Ureña-Peralta,Pavla Jendelova et al.
Francisco Javier Rodriguez-Jimenez et al.
Background: Synaptic dysfunction is a major contributor to Alzheimeŕs disease (AD) pathogenesis in addition to the formation of neuritic β-amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau protein. ...
Transcriptome-referenced association study provides insights into the regulation of oil and fatty acid biosynthesis in Torreya grandis kernel [0.03%]
转录组关联分析揭示了植物希望籽中油脂和脂肪酸生物合成的调控机制
Heqiang Lou,Shan Zheng,Wenchao Chen et al.
Heqiang Lou et al.
Introduction: Torreya grandis is a gymnosperm belonging to Taxodiaceae. As an economically important tree, its kernels are edible and rich in oil with high unsaturated fatty acids, such as sciadonic acid. However, the ker...
Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis [0.03%]
茶褐素通过血清素相关信号通路和肠肝轴抑制小鼠肥胖及非酒精性脂肪肝病
Hang-Yu Li,Si-Yu Huang,Dan-Dan Zhou et al.
Hang-Yu Li et al.
Introduction: Non-alcoholic fatty liver disease (NAFLD) with obesity seriously threats public health. Our previous studies showed that dark tea had more potential on regulating lipid metabolism than other teas, and theabr...
Design of a Haversian system-like gradient porous scaffold based on triply periodic minimal surfaces for promoting bone regeneration [0.03%]
基于三重周期最小曲面的类哈弗系统梯度多孔支架设计以促进骨再生
Lan Li,Peng Wang,Huixin Liang et al.
Lan Li et al.
Introduction: The bone ingrowth depth in the porous scaffolds is greatly affected by the structural design, notably the pore size, pore geometry, and the pore distribution. To enhance the bone regeneration capability of s...
Antisense-oligonucleotide co-micelles with tumor targeting peptides elicit therapeutic effects by inhibiting microRNA-21 in the glioblastoma animal models [0.03%]
含有肿瘤靶向肽的反义寡核苷酸共聚米颗粒通过抑制胶质母细胞瘤动物模型中的microRNA-21而产生治疗效果
Youngki Lee,Junkyu Ha,Minkyung Kim et al.
Youngki Lee et al.
Introduction: miRNA-21 (miR-21) is highly expressed in glioblastoma, facilitating tumor growth by blocking the expression of apoptosis-related genes. Therefore, an antisense microRNA oligonucleotide (AMO) against miR-21 w...
The chromatin determinants and Ph1 gene effect at wheat sites with contrasting recombination frequency [0.03%]
具有不同重组频率的染色质决定因素和Ph1基因效应小麦位点
Maciej Majka,Eva Janáková,Irena Jakobson et al.
Maciej Majka et al.
Introduction: Meiotic recombination is one of the most important processes of evolution and adaptation to environmental conditions. Even though there is substantial knowledge about proteins involved in the process, target...
Théo Accogli,Christophe Hibos,Frédérique Vegran
Théo Accogli
Background: Since its discovery, NLRP3 is almost never separated from its major role in the protein complex it forms with ASC, NEK7 and Caspase-1, the inflammasome. This key component of the innate immune response mediate...