Single-cell RNA sequencing combined with proteomics of infected macrophages reveals prothymosin-α as a target for treatment of apical periodontitis [0.03%]
单细胞RNA测序结合感染巨噬细胞的蛋白质组学揭示了プロ胸腺素-α作为治疗牙尖周炎的靶点
Qimei Gong,Xiaomin Lv,Chenxi Liao et al.
Qimei Gong et al.
Introduction: Chronic apical periodontitis (CAP) is a common infectious disease of the oral cavity. Immune responses and osteoclastogenesis of monocytes/macrophages play a crucial role in CAP progression, and this study w...
RvD1 improves resident alveolar macrophage self-renewal via the ALX/MAPK14/S100A8/A9 pathway in acute respiratory distress syndrome [0.03%]
RvD1通过ALX/MAPK14/S100A8/A9通路改善急性呼吸窘迫综合征中驻留肺泡巨噬细胞的自我更新能力
Yang Ye,Qian Yang,Jinling Wei et al.
Yang Ye et al.
Introduction: Acute respiratory distress syndrome (ARDS) is a pulmonary inflammatory process primarily caused by sepsis. The resolution of inflammation is an active process involving the endogenous biosynthesis of special...
A core-shell AuNRs@BUT-16 nanocomposite for enhancement SERS detection and efficient removal of deoxynivalenol [0.03%]
用于脱氧雪腐镰刀菌烯醇增强拉曼检测及高效去除的核壳型AuNRs@BUT-16纳米复合材料
Jing Tao,Yudan Wang,Wenlei Zhai et al.
Jing Tao et al.
Introduction: Deoxynivalenol (DON) is widely found in grains and poses a serious threat to human health, so there is an urgent need to develop methods for its simultaneous removal and detection. The novel metal organic fr...
Advances focusing on the application of decellularization methods in tendon-bone healing [0.03%]
脱细胞方法在肌腱骨骼修复中的应用进展
Sheng Zhong,Yujian Lan,Jinyu Liu et al.
Sheng Zhong et al.
Background: The tendon or ligament is attached to the bone by a triphasic but continuous area of heterogeneous tissue called the tendon-bone interface (TBI). The rapid and functional regeneration of TBI is challenging owi...
Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies [0.03%]
基于多组学技术的慢性砷暴露引起的鸡肝脏-微生物群-肠道轴紊乱的生物毒性研究
Jiayi Li,Changming Guo,Yan Liu et al.
Jiayi Li et al.
Introduction: Arsenic has been ranked as the most hazardous substance by the U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public health conc...
The circUbqln1, regulated by XBP1s, interplays with 14-3-3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism [0.03%]
由XBP1s调控的circUbqln1通过控制PRODH活性和脯氨酸代谢与14-3-3ζ相互作用抑制胶原蛋白合成并促进骨关节炎的发展
Naibo Feng,Yuanlan Ye,Yiming Pan et al.
Naibo Feng et al.
Introduction: Osteoarthritis (OA) is a degenerative bone disease associated with ageing, characterized by joint pain, stiffness, swelling and deformation. Currently, pharmaceutical options for the clinical treatment of OA...
HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis [0.03%]
HSPA12A充当分子支架蛋白抑制心脏成纤维细胞的激活和心肌纤维化
Qian Mao,Xiaojin Zhang,Jinna Yang et al.
Qian Mao et al.
Introduction: Cardiac fibrosis is the main driver for adverse remodeling and progressive functional decline in nearly all types of heart disease including myocardial infarction (MI). The activation of cardiac fibroblasts ...
Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds [0.03%]
分层双层微针实现糖尿病全厚皮伤口的多中心皮肤再生
Xiaoqi Huang,Xingtang Niu,Yuan Ma et al.
Xiaoqi Huang et al.
Introduction: Managing large chronic wounds presents significant challenges because of inadequate donor sites, infection, and lack of structural support from dermal substitutes. Hydrogels are extensively used in various f...
Yan Wu,Peiran Song,Miaomiao Wang et al.
Yan Wu et al.
Background: Bone metabolism can maintain the normal homeostasis and function of bone tissue. Once the bone metabolism balance is broken, it will cause osteoporosis, osteoarthritis, bone defects, bone tumors, or other bone...
Therapeutic effect of phycocyanin on chronic obstructive pulmonary disease in mice [0.03%]
藻红蛋白对小鼠慢性阻塞性肺疾病的作用效果研究
Wenjun Li,Yuanyuan Li,Qi Wang et al.
Wenjun Li et al.
Introduction: The prevention and treatment of chronic obstructive pulmonary disease (COPD) is closely tied to antioxidation and anti-inflammation. Phycocyanin (PC) has numerous pharmacological effects, such as antioxidati...