Integrative epitranscriptomic and transcriptomic characterization in human colorectal cancer [0.03%]
人类结直肠癌中的表观转录组和转录组的综合分析
Ting Gong,Sudhir Kumar Rai,Yong Zhu et al.
Ting Gong et al.
Introduction: Despite significant progress in understanding the molecular basis of colorectal cancer (CRC), the precise mechanisms driving its development and progression remain poorly defined. This gap limits the identif...
Charge reversible-natural light responsive nanoparticles enable targeted herbicide delivery and reduction of mammalian toxicity [0.03%]
可逆性响应天然光线的纳米粒子实现除草剂靶向投递并降低对哺乳动物的毒性
Junhu Xu,Wei Wang,Kunyan Guo et al.
Junhu Xu et al.
Introduction: Mammalian health risks due to agrochemical exposure are becoming a global concern, increasingly. Long-term exposure to diquat (DQ) leads to multiple organ dysfunctions and increase mammal mortality. Despite ...
Tryptophan metabolism in psoriasis and its complications: Future opportunities [0.03%]
银屑病及其并发症中的色氨酸代谢及未来研究方向
Xiyuan He,Yueting Mo,Peixin Shi et al.
Xiyuan He et al.
Tryptophan (Trp) metabolism encompasses primary three pathways: the kynurenine pathway, the serotonin pathway, and the indole pathway. These pathways are intricately involved in the physiological and pathological processes underlying psoria...
Cancer stem cell plasticity in shaping drug resistance landscapes in prostate cancer [0.03%]
前列腺癌中的癌症干细胞可塑性在形成耐药图谱方面的功能
Xiaoyu Zhang,Xiaoqing Zhang,Qing Bao et al.
Xiaoyu Zhang et al.
Background: Prostate-related diseases exhibit an extremely high incidence among aging males, including Benign Prostatic Hyperplasia (BPH) and prostate Cancer (PCa). Prostate stem cells are critical for prostate developmen...
Epac1 deletion attenuates Müller glial pathological activation and mitigates retinal neurodegeneration in ischemia-induced retinopathy [0.03%]
EPAC1缺失可减轻缺血性视网膜病变引起的Müller胶质细胞的病理活化并缓解神经退行性疾病
Shuizhen Shi,Fan Xia,Zhongqiao Lu et al.
Shuizhen Shi et al.
Introduction: Ischemia-induced retinopathies, such as retinopathy of prematurity and proliferative diabetic retinopathy, are major causes of vision loss. Both pathological neovascularization and neuronal damage contribute...
The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision [0.03%]
同型半胱氨酸-叶酸轴与心肌肥厚及心力衰竭的复杂关联：从机制探讨至临床实践展望
Yi Wang,LaBapuchi,Meiqing Liu et al.
Yi Wang et al.
Background: Globally, the pathogenesis and progression of many human diseases are intimately associated with folate metabolism disorder. Emerging evidence from recent investigations has underscored the pivotal role of fol...
Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints [0.03%]
肿瘤相关巨噬细胞中的氨基酸代谢动态重塑：促进免疫抑制、重塑肿瘤微环境和解锁代谢检查点
Beibei Ran,Lingjun Xiao,Yan Liu et al.
Beibei Ran et al.
Background: Tumor-associated macrophages depend on their amino acid metabolism to determine their properties and immune function and play important roles in the tumor microenvironment (TME). Although in previous studies, ...
Trained immunity modulators: A new frontier in immunoregulation and disease intervention [0.03%]
训练免疫调节剂：免疫调节和疾病干预的新前沿
Jiao Chen,Chenxi Wang,Shilin Chen et al.
Jiao Chen et al.
Background: Immunotherapy has emerged as one of the most revolutionary approaches in disease treatments. However, most current and emerging immunotherapeutic strategies primarily target the adaptive immune system. Recent ...
Shiwen Liu,Jun Cai,Zhenzhen Chen
Shiwen Liu
Background: Blood vessels are continuously exposed to mechanical forces, mainly including shear stress, cyclic stretch, and hydrostatic pressure. These forces regulate the functions of endothelial cells (ECs) and vascular...
Multi-omics elucidation of recombinant collagen-mediated modulation of mesenchymal stem cell functions [0.03%]
组学阐明重组胶原蛋白介导的间充质干细胞功能调控机制
Taishan Liu,Juanli Dang,Chenhui Zhu et al.
Taishan Liu et al.
Introduction: Regenerative medicine leverages the potential of mesenchymal stem cells (MSCs) and biomaterials to overcome the limitations of traditional organ transplantation. Collagen, a key extracellular matrix componen...