Characterization of immune features and discovery of potential biomarkers for ankylosing spondylitis using deep plasma proteomics [0.03%]
利用深血浆蛋白质组学表征免疫特征并发现银屑病关节炎的潜在生物标志物
Xiaohan Xu,Wanlin Liu,Bo Pang et al.
Xiaohan Xu et al.
Introduction: Ankylosing spondylitis (AS) is a systemic inflammatory disorder that predominantly involves the axial skeleton, often leading to irreversible structural damage and disability. Although several therapeutic me...
In newly diagnosed diabetes, hyperglycemia is associated with increased brain iron deposition, measured by MRI-based Quantitative Susceptibility Mapping (QSM) [0.03%]
在新诊断的糖尿病患者中，高血糖与基于MRI的定量磁敏感度mapping(QSM)测量的脑铁沉积增加有关
Maria Agnese Pirozzi,Fabrizio Esposito,Francesca Trojsi et al.
Maria Agnese Pirozzi et al.
Background: Long-term Type 2 diabetes mellitus (T2DM) affects multiple organs and systems throughout the body, including the cardiovascular, renal, and nervous systems. In the brain, T2DM impacts brain function, leading t...
Research progress on immunoprotective mechanisms of enteric fever and vaccine development [0.03%]
伤寒免疫保护机制研究进展及疫苗开发方向
Ying Chen,Lingwei Chen,Yanzhen Lin et al.
Ying Chen et al.
Background: Enteric fever remains a serious global health challenge. Effective control of enteric fever depends on clean water and proper sanitation, which remains unattainable in resource-limited settings. Vaccination is...
Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson's disease [0.03%]
纤连蛋白通过α5β3整合素促进帕金森病中α-突触核蛋白聚集和线粒体功能障碍
Zifeng Huang,Jialing Zheng,Feilan Yuan et al.
Zifeng Huang et al.
Introduction: Blood-brain barrier(BBB) disruption promotes the influx of the fibrinogen(FG); however, it remains unknown whether FG deposit contributes to neurodegeneration in Parkinson's disease(PD). ...
Burden of female disease among adolescents and young adults aged 10-24 years in South Asia and Sub-Saharan Africa regions, 1990-2021: a systematic analysis from the Global Burden of Disease Study 2021 [0.03%]
2021年全球疾病负担研究中1990年至2021年南亚和撒哈拉以南非洲地区10至24岁青少年女性健康问题的系统分析
Jiahong Sun,Yongliang Zhu,Danyi Huang et al.
Jiahong Sun et al.
Introduction: Female diseases pose significant challenges in South Asia and Sub-Saharan Africa, particularly among adolescent girls and young women, who often receive insufficient attention. ...
Exosomal miR-1246 of adipose stem cells attenuates obesity by polarizing M2 macrophages, reducing fat mass, and beiging of white adipose tissue [0.03%]
脂肪干细胞的外泌体miR-1246通过极化M2型巨噬细胞、减少脂肪质量和诱导白色脂肪组织褐色化来缓解肥胖效应
Bo Wang,Qingmeng Pi,Ali Mohsin et al.
Bo Wang et al.
Introduction: Adipose stem cells (ADSC) have demonstrated therapeutic potential in ameliorating obesity and metabolic disorders, with their exosomes showing comparable therapeutic effects. However, the underlying molecula...
Targeting the bile acid receptor TGR5 with Gentiopicroside to activate Nrf2 antioxidant signaling and mitigate Parkinson's disease in an MPTP mouse model [0.03%]
番泻醇通过活化Nrf2抗氧化信号通路靶向TGR5受体从而缓解MPTP诱导的小鼠帕金森病模型症状的研究
Ying Gao,Xiuling Tang,Jingyue Yao et al.
Ying Gao et al.
Introduction: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by classical symptoms including bradykinesia, rest tremor and rigidity. Oxidative stress and mitochondrial dysfunction are recogn...
Urinary proteins from stone formers promote calcium oxalate crystallization, growth and aggregation via oxidative modifications [0.03%]
结石形成者的尿蛋白通过氧化修饰促进草酸钙结晶、生长和聚集
Sudarat Hadpech,Paleerath Peerapen,Sakdithep Chaiyait et al.
Sudarat Hadpech et al.
Introduction: Various urinary parameters are used for determining kidney stone risk. However, almost all of the widely used lithogenic indices rely on urinary concentrations of small molecules/ions and pH. ...
Fish oil reduces intestinal fat absorption by promoting lacteal junction zippering via GPR120-VEGFR3-MLCK pathway [0.03%]
鱼油通过GPR120-VEGFR3-MLCK通路促进乳糜管上皮“拉链”闭合从而减少肠道脂肪吸收
Junfeng Wang,Liling Cai,Jinhao Liu et al.
Junfeng Wang et al.
Introduction: Diet-induced obesity can be improved by reducing intestinal fat absorption. Fish oil, enriched in n-3 PUFAs such as DHA and EPA, has shown promise in weight reduction. However, the role of fish oil in regula...
Dynamic heterogeneity towards drug resistance in AML cells is primarily driven by epigenomic mechanism unveiled by multi-omics analysis [0.03%]
多组学分析揭示急性髓系白血病细胞的动态异质性主要由表观遗传机制驱动
Yulong Zhang,Yanfang Lu,Liyao Mai et al.
Yulong Zhang et al.
Introduction: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by aggressive proliferation and chemoresistance, leading to poor patient outcomes. Despite advances in chemotherapy, resistance mechanis...