Rutin Combats Salmonella infection through virulence suppression and gut barrier maintenance [0.03%]
rutin通过抑制毒力和维持肠道屏障来抵抗沙门氏菌感染
Tao Wang,Xinyou Zhang,Haihua Feng et al.
Tao Wang et al.
Introduction: Salmonella Typhimurium (S. Typhimurium) is a major zoonotic pathogen causing severe gastroenteritis and septicemia. Traditional antibiotics targeting bacterial growth face increasing resistance challenges, w...
Chac1 deficiency confers sepsis resistance by enriching gut microbiota-derived indole-3-carboxylic acid to drive macrophage metabolic shifts [0.03%]
CHAT1缺乏通过丰富肠道菌群来源的吲哚-3-羧酸来驱动巨噬细胞代谢转变从而增强对败血症的抵抗力
Jing-Juan Hu,Si-Yuan Feng,Ling Wu et al.
Jing-Juan Hu et al.
Introduction: Sepsis is a life-threatening dysregulated host response to infection, lacks effective therapies. ChaC glutathione-specific γ-glutamylcyclotransferase 1 (CHAC1) is elevated in sepsis and correlates with seve...
Physiological and pathological functions of TAF15 in neurodegenerative diseases and cancers [0.03%]
TAF15在神经退行性疾病和癌症的生理及病理功能
Congcong Liu,Lanxia Meng,Zhentao Zhang
Congcong Liu
Background: TATA-box binding protein associated factor 15 (TAF15) is a multifunctional DNA/RNA-binding protein that plays pivotal roles in transcription regulation, precursor mRNA splicing, and cellular stress responses. ...
Differential homogalacturonan metabolic mechanisms in cellular regions of fruits during postharvest ripening and senescence [0.03%]
采后成熟和衰老过程中果实细胞区室的异质性果胶代谢机制
Weinan Huang,Jiayue Jin,Songde Wu et al.
Weinan Huang et al.
Introduction: Postharvest fruit textural changes, driven by cell wall remodeling, primarily manifest as softening or lignifying. Methylesterification of homogalacturonan (HG) pectin directly impacts cell wall biomechanics...
Frequent fried food intake fuels incidence of metabolic associated fatty liver disease attributed to acrylamide-induced hepatic lipid disorders through arachidonic acid-PGE2-PPARα axis [0.03%]
频繁摄入油炸食物通过花生四烯酸-PGE2-PPARα轴诱发丙烯酰胺致肝脏脂质代谢紊乱促进代谢相关性脂肪肝疾病发生发展的研究
Xuzhi Wan,Xiaohui Liu,Denghui Meng et al.
Xuzhi Wan et al.
Introduction: Fried food and hazard factors, particularly acrylamide, have been implicated in adverse health outcomes. However, how fried food consumption fuels the development of metabolic associated fatty liver disease ...
New Perspectives on oligodendrocytes: Guardians of iron homeostasis and defenders against ferroptosis [0.03%]
少突胶质细胞新视角：铁稳态的守护者和铁死亡的捍卫者
Fang Li,Shutian Tao,Sitong Wang et al.
Fang Li et al.
Background: Oligodendrocytes (OLs) play a pivotal role in preserving iron homeostasis within the central nervous system (CNS), as they harbor the largest cellular iron reservoir essential for myelination. However, this in...
Advances in super-resolution imaging technology bring new perspectives to cytoskeleton mechanism research [0.03%]
超分辨率成像技术的进步为细胞骨架机制研究带来新视角
Song Peng,Ferdinand Ndikuryayo,Xue-Yan Gong et al.
Song Peng et al.
The cytoskeleton constitutes the fundamental structural framework governing cellular morphology and the regulation of intracellular cellular processes. Its nanoscale architecture and dynamics are essential for understanding the mechanisms o...
Long noncoding RNA AFAP1-AS1 aggravates immunotherapy resistance in NSCLC by enhancing JAK2 and TYK2 translation [0.03%]
长非编码RNA AFAP1-AS1通过增强JAK2和TYK2的翻译来加重非小细胞肺癌免疫疗法耐药性
Yijie Zhang,Jiawei Ouyang,Qijia Yan et al.
Yijie Zhang et al.
Background: Lung cancer is the most common and deadliest malignancy worldwide, with about 85% of cases being non-small cell lung cancer (NSCLC). Although targeting PD-1/PD-L1 with immune checkpoint inhibitors has revoluti...
Luteolin as a novel therapeutic for diabetic kidney disease: Targeting the ADAM10-TREM2 pathway [0.03%]
黄酮类化合物山柰酚可作为糖尿病肾病的新型治疗药物：靶向ADAM10-TREM2通路
Lingchen Deng,Yong Wang,Chunru Shi et al.
Lingchen Deng et al.
Background: Diabetic kidney disease (DKD) is a common condition with few treatment options, and inflammation plays a pivotal role in its progression. Luteolin, a natural compound found in traditional Chinese herbs, is kno...
Genome-wide CRISPR screen identifies TAF1C as an epigenetic determinant of lipid deposition via ACSL4-dependent ferroptosis in MASLD [0.03%]
全基因组CRISPR筛选鉴定出TAF1C通过ACSL4依赖性铁死亡在MASLD中作为脂质沉积表观遗传决定因子的作用
Yihang Gong,Jiandi Chen,Feng Zhang et al.
Yihang Gong et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most prevalent liver disease, garnering considerable attention. Currently, there are no satisfactory drugs available...