Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition [0.03%]
血浆载脂蛋白E通过LRP1和PLAU双受体介导抑制TGF-β/Smad途径治疗肺纤维化
Haiyang Zhang,Yu Xie,Gang Wei et al.
Haiyang Zhang et al.
Introduction: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options, thus necessitating novel strategies targeting upstream fibrogenic drivers; the exact impact of apoli...
Process-Programmed Extraction-Structure-Activity (ESAR) relationships in edible and medicinal mushroom polysaccharides: a mechanistic and application-oriented framework [0.03%]
基于可食药用真菌多糖的“过程-程序抽提-构效关系”机制与应用框架研究
Cunchao Zhao,Muhammad Aaqil,Rui He et al.
Cunchao Zhao et al.
Background: Edible and medicinal mushroom polysaccharides (EMMPs) display wide-ranging bioactivities, yet progress has been limited by siloed workflows. Extraction, structural analysis, and biological evaluation are often...
Cu/Fe co-doped Sphagnum palustre-derived biochar for the synergistic adsorption and photocatalytic removal of tetracycline hydrochloride [0.03%]
铜铁共掺泥炭藓生物炭用于四环素盐的协同吸附及光催化降解研究
Qing Xiang,Zhen Wang,Liang Luo et al.
Qing Xiang et al.
Introduction: The widespread presence of antibiotic pollutants, such as tetracycline hydrochloride (TCH), causes significant environmental and public health concerns. Biochar-based photocatalysts derived from renewable bi...
Single-Cell RNA sequencing identifies NAMPT as a potential therapeutic target in autoimmune uveitis [0.03%]
单细胞RNA测序鉴定出NMPP为自身免疫性葡萄膜炎的潜在治疗靶点
Yingying Wen,Lei Zhu,Zhaohao Huang et al.
Yingying Wen et al.
Introduction: Autoimmune uveitis (AU) is an autoimmune disease of the eye that can lead to irreversible vision loss. Current therapies are limited by suboptimal efficacy and substantial side effects, highlighting the urge...
Coordinated regulation of glutathione S-transferases confers metabolic flexibility in multi-insecticide-resistant Frankliniella occidentalis (Pergande) [0.03%]
谷胱甘肽S-转移酶的协同调节赋予二斑叶螨多杀菌剂抗性代谢灵活性
Jing Wang,Sirui Chen,Yulei Wu et al.
Jing Wang et al.
Introduction: The evolution of multi-insecticide resistance in insect pests threatens global food security. Although glutathione S-transferases (GSTs) are implicated in detoxification, the coordinated mechanism by which s...
Cetobacterium somerae ZNN-1 promotes goblet cell differentiation through glutamine-mediated Notch signaling suppression [0.03%]
芽孢杆菌门塞托伯特菌促进杯状细胞分化的新机制
Nan-Nan Zhou,Jun-Xi Liu,Tong Wang et al.
Nan-Nan Zhou et al.
Introduction: The gut microbiota acts as a crucial mediator in the interaction between the diet components and the host metabolism. However, the molecular mechanism by which the gut microbiota adapts to dietary components...
Discovery of a small-molecule inhibitor of eIF4E suppressing tumor proliferation via lipid metabolic reprogramming [0.03%]
一种小分子eIF4E抑制剂通过脂质代谢重编程抑制肿瘤增殖的发现
Yuxi Lin,Xiaoyi Bai,Shuo Li et al.
Yuxi Lin et al.
Introduction: The eukaryotic translation initiation factor 4E (eIF4E) has emerged as a compelling target for cancer therapeutics due to its pivotal role in regulating cap-dependent translation of oncogenic mRNAs and its i...
Thbs1+ extracellular vesicles from irradiated tumors induce cardiac wasting via PERK-eIF2α-Atf4 signaling [0.03%]
辐照肿瘤来源的Thbs1+外泌体通过PERK-eIF2α-ATF4信号引起心脏消耗综合征
Song Gao,Wenzhi Liu,Jingquan He et al.
Song Gao et al.
Aims: Cardiac muscle wasting is a significant complication observed in lung cancer patients receiving radiotherapy. Radiotherapy, a commonly used anticancer treatment, is known to cause cardiovascular complications; howev...
Spatial radiomics-based interpretable multimodal machine learning model enhances outcomes prediction for minor stroke: A multicenter cohort study [0.03%]
基于空间影像组学的可解释多模态机器学习模型改善了小卒中的预后预测：一项多中心队列研究
Liang Jiang,Yi Zhou,Qiang Xu et al.
Liang Jiang et al.
Introduction: Accurately identifying unfavorable outcomes is crucial for the clinical management of minor stroke. Conventional imaging prediction models, such as radiomics, rely on region-of-interest analyses that extract...
Strategy and efficiency-redefined discovery of novel nanomolar tyrosinase inhibitors: AI de novo molecular generation + expert-guided structural optimization [0.03%]
策略与效率：重新定义的新型纳摩尔酪氨酸酶抑制剂发现方法——AI从头分子生成与专家引导的结构优化相结合的方法
Yinyan Sun,Jiahui Wang,Wenchao Chen et al.
Yinyan Sun et al.
Artificial intelligence (AI) has played an excellent supporting role in novel drug discovery and development. This study introduces a reinforcement learning (RL) model based on the Soft Actor-Critic (SAC) algorithm for AI-driven de novo mol...