SAMHD1 promotes cardiac repair post myocardial infarction by targeting NR4a1 to regulate macrophage metabolic reprogramming [0.03%]
SAMHD1通过靶向NR4a1调节巨噬细胞代谢重编程促进心梗后心脏修复
Yu-Lan Ma,Hai-Yang Ni,Zhen Guo et al.
Yu-Lan Ma et al.
Introduction: Myocardial infarction (MI) is one of the leading causes of high mortality worldwide. Accumulating evidence suggests that macrophages emerge as the predominant immune population within the post-MI cardiac env...
Design of strictly orthogonal biosensors for maximizing renewable biofuel overproduction [0.03%]
严格正交生物传感器的设计以实现可再生生物燃料的最大增产
Tong Wu,Dongli Yan,Sheng Lin et al.
Tong Wu et al.
Introduction: Transcription factors (TFs) activate transcriptional initiation by binding specific signal molecules (SMs), yet designing TFs to precisely target non-natural SMs remains challenging. ...
Epigenetic orchestration of cancer-immune dynamics: mechanisms, technologies, and clinical advancements [0.03%]
表观遗传调控肿瘤免疫互作机制、技术及临床应用研究进展
Yuanjun Lu,Shuoshuo Ma,Yau-Tuen Chan et al.
Yuanjun Lu et al.
Background: Epigenetic dysregulation plays a pivotal role in cancer immune evasion by orchestrating tumour antigen silencing, immune cell dysfunction, and the formation of an immunosuppressive microenvironment. By disrupt...
Glycoursodeoxycholic acid 3 sulfate sodium links hemodynamics and bile acid metabolism in aortic stenosis [0.03%]
硫酸钠鹅去氧胆酸-3-硫酸钠连接主动脉瓣狭窄的血液动力学和胆汁酸代谢
Min Zhu,Kun Hua,Huiqing Wang et al.
Min Zhu et al.
Introduction: Aortic stenosis (AS) involves aortic obstruction, pressure overload, reduced cardiac output, and impaired organ arterial hemodynamics. Many patients remain at risk of rehospitalization or death after transca...
Targeting CIRP and IL-6R-mediated microglial inflammation to improve outcomes in intracerebral hemorrhage [0.03%]
靶向CIRP和IL-6R介导的小胶质细胞炎症以改善脑内出血的预后
Lisha Ye,Xiaoyan Tang,Fangming Liu et al.
Lisha Ye et al.
Introduction: Cold-inducible RNA-binding protein (CIRP) is an emerging inflammatory mediator implicated in neuronal injury following intracerebral hemorrhage (ICH). However, the underlying mechanisms by which CIRP contrib...
Loss of hepatic ME1 ameliorates MASLD by Suppressing peroxisomal β-Oxidation and Activating Lipophagy/Lipolysis [0.03%]
肝ME1丢失通过抑制过氧化物酶体β-氧化和激活脂噬/脂解来缓解MASLD
Jiawei Zhang,Danyi Wu,Ruoxuan Lei et al.
Jiawei Zhang et al.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) represents an increasing global health problem in association with obesity and insulin resistance without approved pharmacotherapy. Previous s...
Multifunctional antifreeze gelatin-based ionic conductive organohydrogel coupled with electrical stimulation for monitoring and accelerated wound healing [0.03%]
多功能防冻明胶基离子导电有机水凝胶结合电刺激监测和加速伤口愈合
Lantao Wang,Zhengfeng Lu,Qingxin Wu et al.
Lantao Wang et al.
Introduction: Traditional hydrogels with poor mechanical properties and lack of biological activities severely limit their application in wound therapy. Designing multifunctional hydrogels for monitoring and accelerating ...
Microencapsulation alters pyraclostrobin degradation and reshapes soil microbial communities compared to conventional formulations [0.03%]
微胶囊化技术改变了嘧菌酯的降解方式并重塑了土壤微生物群落结构相较于传统剂型的作用
Xi Cheng,Lu Lv,Zhenlan Xu et al.
Xi Cheng et al.
Introduction: Microencapsulated pyraclostrobin (PYR-CS) has gained widespread adoption in agriculture owing to its extended efficacy and reduced risks for non-target organisms. However, knowledge remains limited regarding...
Discovery of natural RORγt inhibitor using machine learning, virtual screening, and in vivo validation [0.03%]
基于机器学习、计算机虚拟筛选和体内验证发现天然RORγt抑制剂
Hojin Yoo,Sang-Jun Han,Jeong-Eun Lee et al.
Hojin Yoo et al.
Introduction: Retinoic acid receptor-related orphan receptor gamma t (RORγt) is a crucial transcription factor regulating Th17 cells, which secrete the cytokine IL-17. RORγt inhibitors are regarded as a therapeutic moda...
Unraveling the nexus in the neuro-neoplastic progression of colorectal cancer: Potential role of β2-adrenergic receptor (β2-AR) [0.03%]
结直肠癌神经-肿瘤进展中神经-肿瘤轴的潜在联系：β2肾上腺素能受体（β2-AR）的潜在作用
Elizabeth Varghese,Samson Mathews Samuel,Slavomir Hornak et al.
Elizabeth Varghese et al.
Background: Studies on the interaction of cancer cells with other cells (fibroblasts, endothelial cells, and immune cells) of the tumor microenvironment (TME) have led to the development of many novel targeted therapies. ...