Nitric oxide manipulation: a therapeutic target for peripheral arterial disease? [0.03%]
一氧化氮干预：外周动脉疾病的新治疗靶点？
Gareth Williams,Xu Shi-Wen,David Abraham et al.
Gareth Williams et al.
Peripheral Arterial Disease (PAD) is a cause of significant morbidity and mortality in the Western world. Risk factor modification and endovascular and surgical revascularisation are the main treatment options at present. However, a signifi...
Connexins and diabetes [0.03%]
连接蛋白与糖尿病
Josephine A Wright,Toby Richards,David L Becker
Josephine A Wright
Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which...
Martin Haensig,Ardawan Julian Rastan,David Michael Holzhey et al.
Martin Haensig et al.
Atrial fibrillation (AF) can be found in an increasing number of cardiac surgical patients due to a higher patient's age and comorbidities. Atrial fibrillation is known, however, to be a risk factor for a greater mortality, and one aim of i...
Andrea Caporali,Costanza Emanueli
Andrea Caporali
The term angiogenesis describes the growth of endothelial sprouts from preexisting postcapillary venules. More recently, this term has been used to generally indicate the growth and remodeling process of the primitive vascular network into ...
Hannah J Whittington,Girish G Babu,Mihaela M Mocanu et al.
Hannah J Whittington et al.
Diabetes mellitus is a major risk factor for ischemic heart disease (IHD). Patients with diabetes and IHD experience worse clinical outcomes, suggesting that the diabetic heart may be more susceptible to ischemia-reperfusion injury (IRI). I...
Dhiraj Joshi,Janice Tsui,Rebekah Yu et al.
Dhiraj Joshi et al.
Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Pr...
Stromal-Cell-Derived Factor-1 (SDF-1)/CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg Ischaemia [0.03%]
血管生成疗法中血管细胞衍生生长因子-1(SDF-1/CXCL12)在严重下肢缺血治疗中的潜在作用
Teik K Ho,X Shiwen,D Abraham et al.
Teik K Ho et al.
In the Western world, peripheral vascular disease (PVD) has a high prevalence with high morbidity and mortality. In a large percentage of these patients, lower limb amputation is still required. Studies of ischaemic skeletal muscle disclose...
Appreciating the strengths and weaknesses of transthoracic echocardiography in hemodynamic assessments [0.03%]
经胸超声心动图在血流动力学评估中的优缺点分析
Stephen J Huang,Anthony S McLean
Stephen J Huang
Transthoracic echocardiography (TTE) is becoming the choice of hemodynamic assessment tool in many intensive care units. With an ever increasing number of training programs available worldwide, learning the skills to perform TTE is no longe...
The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease [0.03%]
血管疾病的LOX-1清道夫受体及其治疗意义研究进展
M W Twigg,K Freestone,S Homer-Vanniasinkam et al.
M W Twigg et al.
Cardiovascular disease is the leading cause of death. The disease is due to atherosclerosis which is characterized by lipid and fat accumulation in arterial blood vessel walls. A key causative event is the accumulation of oxidised low densi...
Toll-like receptors in ischaemia and its potential role in the pathophysiology of muscle damage in critical limb ischaemia [0.03%]
缺血条件下 toll 样受体及其在缺血性肌肉损伤中的潜在作用
Hemanshu Patel,Sidney G Shaw,Xu Shi-Wen et al.
Hemanshu Patel et al.
Toll-like receptors (TLRs) are key receptors of the innate immune system which are expressed on immune and nonimmune cells. They are activated by both pathogen-associated molecular patterns and endogenous ligands. Activation of TLRs culmina...