Identification of TNIP1 Polymorphisms by High Resolution Melting Analysis with Unlabelled Probe: Association with Systemic Lupus Erythematosus [0.03%]
高分辨率溶解曲线分析法检测TNIP1基因多态性及其与系统性红斑狼疮的关联研究
Jie Zhang,Yuewen Chen,Yong Shao et al.
Jie Zhang et al.
Background. TNFα-induced protein 3 (TNFAIP3) interacting with protein 1 (TNIP1) acts as a negative regulator of NF-κB and plays an important role in maintaining the homeostasis of immune system. A recent genome-wide association study (GWA...
Ocular manifestations of systemic lupus erythematosus: a review of the literature [0.03%]
系统性红斑狼疮眼部表现的文献回顾
Neal V Palejwala,Harpreet S Walia,Steven Yeh
Neal V Palejwala
About one-third of patients suffering from systemic lupus erythematosus have ocular manifestations. The most common manifestation is keratoconjunctivitis sicca. The most vision threatening are retinal vasculitis and optic neuritis/neuropath...
Bharath Wootla,Makoto Eriguchi,Moses Rodriguez
Bharath Wootla
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with varied clinical presentations and heterogeneous histopathological features. The underlying immunological abnormalities in MS lead to v...
The autoimmune tautology: from polyautoimmunity and familial autoimmunity to the autoimmune genes [0.03%]
自身免疫的自洽性：从多自身免疫和家族自身免疫到自身免疫基因
Juan-Manuel Anaya,Adriana Rojas-Villarraga,Mario García-Carrasco
Juan-Manuel Anaya
Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis [0.03%]
南美六种自身免疫病共有的HLA-II类型：元分析结果
Paola Cruz-Tapias,Oscar M Pérez-Fernández,Adriana Rojas-Villarraga et al.
Paola Cruz-Tapias et al.
The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute t...
Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study [0.03%]
用于治疗多发性硬化症的重组T细胞受体配体(RTL)：一项随机双盲安慰剂对照I期剂量递增研究
Vijayshree Yadav,Dennis N Bourdette,James D Bowen et al.
Vijayshree Yadav et al.
Background. Recombinant T-cell receptor ligand 1000 (RTL1000) is a single-chain protein construct containing the outer two domains of HLA-DR2 linked to myelin-oligodendrocyte-glycoprotein- (MOG-) 35-55 peptide. Analogues of RTL1000 induce T...
Alberto de Zubiria Salgado,Catalina Herrera-Diaz
Alberto de Zubiria Salgado
Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune comp...
Paula Quintero-Ronderos,Gladis Montoya-Ortiz
Paula Quintero-Ronderos
Epigenetics is defined as the study of all inheritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Epigenetic mechanisms such as DNA methylation, histone modification, nucl...
Carlos A Cañas,Felipe Cañas
Carlos A Cañas
It is an inherent part of living to be in constant modification, which are due to answers resulting from environmental changes. The different systems make adaptations based on natural selection. With respect to the immune system of mammals,...
Ricardo A Cifuentes,Daniel Restrepo-Montoya,Juan-Manuel Anaya
Ricardo A Cifuentes
There is genetic evidence of similarities and differences among autoimmune diseases (AIDs) that warrants looking at a general panorama of what has been published. Thus, our aim was to determine the main shared genes and to what extent they ...