M. paratuberculosis Heat Shock Protein 65 and Human Diseases: Bridging Infection and Autoimmunity [0.03%]
热休克蛋白65与 MAP 和人类疾病：感染和自身免疫之间的桥梁
Coad Thomas Dow
Coad Thomas Dow
Mycobacterium avium subspecies paratuberculosis (MAP) is the known infectious cause of Johne's disease, an enteric inflammatory disease mostly studied in ruminant animals. MAP has also been implicated in the very similar Crohn's disease of ...
HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation [0.03%]
HSP70和HSP90通过调节胞外抗原向细胞质的转移从而不同地调控交叉呈递作用
Yu Kato,Chiaki Kajiwara,Ikuo Ishige et al.
Yu Kato et al.
Antigens (Ag) from cancer or virus-infected cells must be internalized by dendritic cells (DCs) to be presented to CD8(+) T cells, which eventually differentiate into Ag-specific cytotoxic T lymphocytes (CTLs) that destroy cancer cells and ...
Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort [0.03%]
大而多民族的SLE患者队列中，多种自身抗体与淋巴细胞减少、蛋白尿及管型相关
Rufei Lu,Julie M Robertson,Benjamin F Bruner et al.
Rufei Lu et al.
Purpose. This study evaluates high-throughput autoantibody screening and determines associated systemic lupus erythematosus (SLE) clinical features in a large lupus cohort. Methods. Clinical and demographic information, along with serum sam...
Neonatal lupus erythematosus [0.03%]
新生儿狼疮
Kam Lun Hon,Alexander K C Leung
Kam Lun Hon
Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually be...
The Role of M. leprae Hsp65 Protein and Peptides in the Pathogenesis of Uveitis [0.03%]
M.leprae Hsp65蛋白及其肽段在葡萄膜炎发病机制中的作用研究
Alessandra Gonçalves Commodaro,Eliana Blini Marengo,Jean Pierre S Peron et al.
Alessandra Gonçalves Commodaro et al.
Experimental autoimmune uveitis (EAU) is a well established model for immune-mediated organ-specific disease. Our group has recently shown that the M. leprae Hsp65 aggravated the uveitis in mice; in the present study, we evaluated the actio...
Athina Pyrpasopoulou,Sofia Chatzimichailidou,Spyros Aslanidis
Athina Pyrpasopoulou
Vascular disease, either as a direct complication of the disease or developing as an accompanying comorbidity impairs significantly the quality of life of patients with SLE and represents the most frequent cause of death in established lupu...
Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators [0.03%]
糖尿病代谢控制改善、HSP60及促炎症介质的关系
Claudio Blasi,Eunjung Kim,Anne A Knowlton
Claudio Blasi
The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock pro...
Osteonecrosis in systemic lupus erythematosus: an early, frequent, and not always symptomatic complication [0.03%]
系统性红斑狼疮的骨坏死：一个早期、常见的并发症，并非总是有症状的
Paola Caramaschi,Domenico Biasi,Ilaria Dal Forno et al.
Paola Caramaschi et al.
Osteonecrosis may complicate the course of systemic lupus erythematosus and may contemporaneously affect multiple joints. The major risk factor associated with the development of osteonecrosis is the use of glucocorticoid at high doses. Rec...
The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis [0.03%]
透明质酸和CD44在狼疮性肾炎发病机制中的作用
Susan Yung,Tak Mao Chan
Susan Yung
Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems. Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within t...
Luís Uva,Diana Miguel,Catarina Pinheiro et al.
Luís Uva et al.
Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (A...