Heat shock proteins: pathogenic role in atherosclerosis and potential therapeutic implications [0.03%]
热休克蛋白在动脉粥样硬化中的病理作用及潜在治疗意义
Arman Kilic,Kaushik Mandal
Arman Kilic
Heat shock proteins (HSPs) are a highly conserved group of proteins that are constitutively expressed and function as molecular chaperones, aiding in protein folding and preventing the accumulation of misfolded proteins. In the arterial wal...
Autoimmune hepatitis as a unique form of an autoimmune liver disease: immunological aspects and clinical overview [0.03%]
自身免疫性肝炎作为自身免疫性肝病的一种独特形式：免疫学特点及临床概述
Hind I Fallatah,Hisham O Akbar
Hind I Fallatah
Autoimmune hepatitis (AIH) is a unique form of immune-mediated disease that attacks the liver through a variety of immune mechanisms. The outcomes of AIH are either acute liver disease, which can be fatal, or, more commonly, chronic progres...
Systemic lupus erythematosus [0.03%]
系统性红斑狼疮
Hiroshi Okamoto,Ricard Cervera,Tatiana S Rodriguez-Reyna et al.
Hiroshi Okamoto et al.
A Novel Method for Real-Time, Continuous, Fluorescence-Based Analysis of Anti-DNA Abzyme Activity in Systemic Lupus [0.03%]
一种实时连续荧光法分析系统性红斑狼疮抗DNA抗体酶活性的新方法
Michelle F Cavallo,Anna M Kats,Ran Chen et al.
Michelle F Cavallo et al.
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of antibodies against a variety of self-antigens including nucleic acids. These antibodies are cytotoxic, catalytic (hydrolyzing DNA, RNA, and prote...
A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts [0.03%]
人和非人类宿主与重症肌无力相关的表位库的比较
Kerrie Vaughan,Yohan Kim,Alessandro Sette
Kerrie Vaughan
Here we analyzed the molecular targets associated with myasthenia gravis (MG) immune responses, enabled by an immune epitope database (IEDB) inventory of approximately 600 MG-related epitopes derived from 175 references. The vast majority o...
Angela Senders,Helané Wahbeh,Rebecca Spain et al.
Angela Senders et al.
Background. Mind-body therapies are used to manage physical and psychological symptoms in many chronic health conditions. Objective. To assess the published evidence for using mind-body techniques for symptom management of multiple sclerosi...
CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity [0.03%]
热休克蛋白依赖CD91调节免疫反应在自身免疫中的作用
Robert J Binder,Yu Jerry Zhou,Michelle N Messmer et al.
Robert J Binder et al.
Heat shock proteins (HSPs) have been known for decades for their ability to protect cells under stressful conditions. In the 1980s a new role was ascribed for several HSPs given their ability to elicit specific immune responses in the setti...
Linkage of multiple sclerosis and guillain-barre syndrome: a population-based survey in isfahan, iran [0.03%]
伊朗伊斯法罕多发性硬化和吉兰-巴雷综合征的关联：基于人口的调查研究
Masoud Etemadifar,Peyman Roomizadeh,Seyed-Hossein Abtahi et al.
Masoud Etemadifar et al.
Background. Multiple Sclerosis (MS) and Guillain Barre Syndrome (GBS) are autoimmune demyelinating disorders of Central and Peripheral Nervous system, respectively. The coexistence of these two syndromes in an individual's life span is rare...
Annapurni Jayam Trouth,Alok Dabi,Noha Solieman et al.
Annapurni Jayam Trouth et al.
Acquired myasthenia gravis is a relatively uncommon disorder, with prevalence rates that have increased to about 20 per 100,000 in the US population. This autoimmune disease is characterized by muscle weakness that fluctuates, worsening wit...
Role of Structure-Based Changes due to Somatic Mutation in Highly Homologous DNA-Binding and DNA-Hydrolyzing Autoantibodies Exemplified by A23P Substitution in the VH Domain [0.03%]
基于结构的突变对高同源DNA结合和DNA水解自身抗体的作用——以VH域中A23P替代为例
A V Kozyr,A V Kolesnikov,A E Khlyntseva et al.
A V Kozyr et al.
Anti-DNA autoantibodies are responsible for tissue injury in lupus. A subset of DNA-specific antibodies capable of DNA cleavage can be even more harmful after entering the living cells by destroying nuclear DNA. Origins of anti-DNA autoanti...