Harrie J M Gijsen,Marc Mercken
Harrie J M Gijsen
γ-Secretase modulation has been proposed as a potential disease modifying anti-Alzheimer's approach. γ-Secretase modulators (GSMs) cause a product shift from the longer amyloid-beta (Aβ) peptide isoforms to shorter, more soluble, and les...
γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production [0.03%]
γ分泌酶对淀粉样前体蛋白跨膜区的水解：β淀粉样蛋白生成中连续性的三肽和四肽释放过程
Mako Takami,Satoru Funamoto
Mako Takami
γ-Secretase cleaves the carboxyl-terminal fragment (βCTF) of APP not only in the middle of the transmembrane domain (γ-cleavage), but also at sites close to the membrane/cytoplasm boundary (ε-cleavage), to produce the amyloid β protein...
Florbetaben PET in the Early Diagnosis of Alzheimer's Disease: A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps [0.03%]
氟乙苯丙胺-PET在早期阿尔茨海默病诊断中的潜在价值及关键数据缺口：离散事件模拟研究
Shien Guo,Denis Getsios,Luis Hernandez et al.
Shien Guo et al.
The growing understanding of the use of biomarkers in Alzheimer's disease (AD) may enable physicians to make more accurate and timely diagnoses. Florbetaben, a beta-amyloid tracer used with positron emission tomography (PET), is one of thes...
Modulation of gamma-secretase for the treatment of Alzheimer's disease [0.03%]
γ分泌酶调节治疗阿尔茨海默病的研究进展及未来前景
Barbara Tate,Timothy D McKee,Robyn M B Loureiro et al.
Barbara Tate et al.
The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)-formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline-are triggered by Aβ peptide dy...
Morphologic and functional effects of gamma secretase inhibition on splenic marginal zone B cells [0.03%]
γ分泌酶抑制对脾边缘区B细胞形态和功能的影响
Maria Cristina de Vera Mudry,Franziska Regenass-Lechner,Laurence Ozmen et al.
Maria Cristina de Vera Mudry et al.
The γ-secretase complex is a promising target in Alzheimer's disease because of its role in the amyloidogenic processing of β-amyloid precursor protein. This enzyme also catalyzes the cleavage of Notch receptor, resulting in the nuclear t...
Neelum T Aggarwal,Manjari Tripathi,Hiroko H Dodge et al.
Neelum T Aggarwal et al.
Lee-Way Jin
Lee-Way Jin
Gizem Donmez
Gizem Donmez
Sirtuins are highly conserved NAD(+)-dependent enzymes that were shown to have beneficial effects against age-related diseases. Aging is the major risk factor for all neurodegenerative disorders including Alzheimer's Disease (AD). Sirtuins ...
The needs of older people with mental health problems: a particular focus on dementia patients and their carers [0.03%]
老年人精神健康需求问题——重点关注痴呆患者及其看护者
Joaquim Passos,Carlos Sequeira,Lia Fernandes
Joaquim Passos
The problems and needs of older people are often associated with mental illness, characterized by a set of clinical manifestations, which constitute important domains for investigation and clinical practice. This paper presents the results ...
Protein clearance mechanisms of alpha-synuclein and amyloid-Beta in lewy body disorders [0.03%]
路易体障碍中α-突触核蛋白和淀粉样蛋白-β的清除机制
Michela Deleidi,Walter Maetzler
Michela Deleidi
Protein clearance is critical for the maintenance of the integrity of neuronal cells, and there is accumulating evidence that in most-if not all-neurodegenerative disorders, impaired protein clearance fundamentally contributes to functional...