Incorporation of 3-aminobenzanthrone into 2'-deoxyoligonucleotides and its impact on duplex stability [0.03%]
3-氨基苯并荧蒽共价结合到脱氧寡核苷酸中及其对双链稳定性和构象的影响研究
Mark Lukin,Tanya Zaliznyak,Francis Johnson et al.
Mark Lukin et al.
3-Nitrobenzanthrone (3NBA), an environmental pollutant and potent mutagen, causes DNA damage via the reaction of its metabolically activated form with the exocyclic amino groups of purines and the C-8 position of guanine. The present work d...
Splicing programs and cancer [0.03%]
拼接与癌症
Sophie Germann,Lise Gratadou,Martin Dutertre et al.
Sophie Germann et al.
Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis. However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies...
Daisuke Miyoshi,Friedrich C Simmel,Souvik Maiti et al.
Daisuke Miyoshi et al.
Caroline Hilmi,Mélanie Guyot,Gilles Pagès
Caroline Hilmi
Angiogenesis has been targeted in retinopathies, psoriasis, and a variety of cancers (colon, breast, lung, and kidney). Among these tumour types, clear cell renal cell carcinomas (RCCs) are the most vascularized tumours due to mutations of ...
Synthesis of specifically modified oligonucleotides for application in structural and functional analysis of RNA [0.03%]
合成特异性修饰的寡核苷酸用于RNA结构和功能分析
Nico Rublack,Hien Nguyen,Bettina Appel et al.
Nico Rublack et al.
Nowadays, RNA synthesis has become an essential tool not only in the field of molecular biology and medicine, but also in areas like molecular diagnostics and material sciences. Beyond synthetic RNAs for antisense, aptamer, ribozyme, and si...
A ssDNA Aptamer That Blocks the Function of the Anti-FLAG M2 Antibody [0.03%]
一种能够阻止抗 FLAG M2 抗体功能的单链 DNA 应用分子
Amanda S Lakamp,Michel M Ouellette
Amanda S Lakamp
Using SELEX (systematic evolution of ligands by exponential enrichment), we serendipitously discovered a ssDNA aptamer that binds selectively to the anti-FLAG M2 antibody. The aptamer consisted of two motifs (CCTTA and TGTCTWCC) separated b...
Jinxiong Wei,Elena Zaika,Alexander Zaika
Jinxiong Wei
TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the r...
Alternative splicing in oncogenic kinases: from physiological functions to cancer [0.03%]
致癌激酶的可变剪接：从生理功能到癌症
Sabine Druillennec,Coralie Dorard,Alain Eychène
Sabine Druillennec
Among the 518 protein kinases encoded by the human kinome, several of them act as oncoproteins in human cancers. Like other eukaryotic genes, oncogenes encoding protein kinases are frequently subjected to alternative splicing in coding as w...
Coupling strategies for the synthesis of Peptide-oligonucleotide conjugates for patterned synthetic biomineralization [0.03%]
肽-寡核苷酸共轭物的合成偶联策略在图案化合成生物矿化中的应用
Joshua D Carter,Thomas H Labean
Joshua D Carter
This work describes preparation strategies for peptide-oligonucleotide conjugates that combine the self-assembling behavior of DNA oligonucleotides with the molecular recognition capabilities of peptides. The syntheses include a solution-ph...
Kimitsuna Watanabe,Shin-Ichi Yokobori
Kimitsuna Watanabe
In animal mitochondria, six codons have been known as nonuniversal genetic codes, which vary in the course of animal evolution. They are UGA (termination codon in the universal genetic code changes to Trp codon in all animal mitochondria), ...