Expansion of the genetic alphabet: unnatural nucleobases and their applications [0.03%]
基因字母的扩充：非天然碱基及其应用
Subhendu Sekhar Bag,Jennifer M Heemstra,Yoshio Saito et al.
Subhendu Sekhar Bag et al.
Specific Roles of MicroRNAs in Their Interactions with Environmental Factors [0.03%]
微核糖核酸与环境因素相互作用中的特定功能角色分析
Juan Wang,Qinghua Cui
Juan Wang
MicroRNAs (miRNAs) have emerged as critical regulators of gene expression by modulating numerous target mRNAs expression at posttranscriptional level. Extensive studies have shown that miRNAs are critical in various important biological pro...
Kha Tram,Pushpinder Kanda,Yingfu Li
Kha Tram
The development of the in vitro selection technique has allowed the isolation of functional nucleic acids, including catalytic DNA molecules (DNAzymes), from random-sequence pools. The first-ever catalytic DNA obtained by this technique in ...
Plant MicroRNA Prediction by Supervised Machine Learning Using C5.0 Decision Trees [0.03%]
基于C5.0决策树的有监督机器学习植物MicroRNA预测方法
Philip H Williams,Rod Eyles,Georg Weiller
Philip H Williams
MicroRNAs (miRNAs) are nonprotein coding RNAs between 20 and 22 nucleotides long that attenuate protein production. Different types of sequence data are being investigated for novel miRNAs, including genomic and transcriptomic sequences. A ...
Maureen McKeague,Maria C Derosa
Maureen McKeague
Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this ...
Dioxaphosphorinane-constrained nucleic Acid dinucleotides as tools for structural tuning of nucleic acids [0.03%]
用于调节核酸结构的限制性核苷酸二聚体
Dan-Andrei Catana,Brice-Loïc Renard,Marie Maturano et al.
Dan-Andrei Catana et al.
We describe a rational approach devoted to modulate the sugar-phosphate backbone geometry of nucleic acids. Constraints were generated by connecting one oxygen of the phosphate group to a carbon of the sugar moiety. The so-called dioxaphosp...
Takashi Kawakami,Hiroshi Murakami
Takashi Kawakami
The presence of a nonproteinogenic moiety in a nonstandard peptide often improves the biological properties of the peptide. Non-standard peptide libraries are therefore used to obtain valuable molecules for biological, therapeutic, and diag...
Potential of peptides as inhibitors and mimotopes: selection of carbohydrate-mimetic peptides from phage display libraries [0.03%]
肽作为抑制剂和模序的潜能——从噬菌体呈递文库中筛选糖链模拟肽的可能性
Teruhiko Matsubara
Teruhiko Matsubara
Glycoconjugates play various roles in biological processes. In particular, oligosaccharides on the surface of animal cells are involved in virus infection and cell-cell communication. Inhibitors of carbohydrate-protein interactions are pote...
Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1 [0.03%]
小非编码RNA靶基因的功能注释提供了脊髓小脑共济失调1型中泛素-蛋白酶体途径调控失常的证据
Stephan Persengiev,Ivanela Kondova,Ronald E Bontrop
Stephan Persengiev
Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disorder caused by the expansion of CAG repeats in the ataxin 1 (ATXN1) gene. In affected cerebellar neurons of patients, mutant ATXN1 accumulates in ubiquitin-positive nuclear inc...
Nucleic-Acid-binding chromophores as efficient indicators of aptamer-target interactions [0.03%]
高效的核苷酸结合光敏配体适配体-靶相互作用指示剂
Kwabena Sarpong,Bhaskar Datta
Kwabena Sarpong
The binding affinity and specificity of nucleic acid aptamers have made them valuable candidates for use as sensors in diagnostic applications. In particular, chromophore-functionalized aptamers offer a relatively simple format for detectio...