Expression Profiling of a Heterogeneous Population of ncRNAs Employing a Mixed DNA/LNA Microarray [0.03%]
利用混合DNA/LNA微阵表达谱分析异质性小非编码RNA群体
Konstantinia Skreka,Marek Zywicki,Michael Karbiener et al.
Konstantinia Skreka et al.
Mammalian transcriptomes mainly consist of non protein coding RNAs. These ncRNAs play various roles in all cells and are involved in multiple regulation pathways. More recently, ncRNAs have also been described as valuable diagnostic tools. ...
Jason M Walsh,Penny J Beuning
Jason M Walsh
The genetic code is continuously expanding with new nucleobases designed to suit specific research needs. These synthetic nucleotides are used to study DNA polymerase dynamics and specificity and may even inhibit DNA polymerase activity. Th...
Didier Auboeuf,Maria Carmo-Fonseca,Juan Valcarcel et al.
Didier Auboeuf et al.
Features of "All LNA" Duplexes Showing a New Type of Nucleic Acid Geometry [0.03%]
"全LNA”型双链核酸的特征及其展现的新一代核酸几何结构
Charlotte Förster,André Eichert,Dominik Oberthür et al.
Charlotte Förster et al.
"Locked nucleic acids" (LNAs) belong to the backbone-modified nucleic acid family. The 2'-O,4'-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and ...
Metal Ion Chelates as Surrogates of Nucleobases for the Recognition of Nucleic Acid Sequences: The Pd(2+) Complex of 2,6-Bis(3,5-dimethylpyrazol-1-yl)purine Riboside [0.03%]
金属离子螯合物作为核酸序列识别的碱基类似物：2,6-双(3,5-二甲基-1H-吡唑基)嘌呤核糖苷钯(II)配合物
Sharmin Taherpour,Tuomas Lönnberg
Sharmin Taherpour
A 2,6-bis(3,5-dimethylpyrazol-1-yl)purine ribonucleoside has been prepared and incorporated as a conventionally protected phosphoramidite into a 9-mer 2'-O-methyl oligoribonucleotide. According to 1H NMR spectroscopic studies, this nucleosi...
MsDpo4-a DinB Homolog from Mycobacterium smegmatis-Is an Error-Prone DNA Polymerase That Can Promote G:T and T:G Mismatches [0.03%]
结核分支杆菌的DinB同源物MSMEG_3157是一种错配容许型DNA聚合酶，可以促进G∶T和T∶G错配
Amit Sharma,Deepak T Nair
Amit Sharma
Error-prone DNA synthesis in prokaryotes imparts plasticity to the genome to allow for evolution in unfavorable environmental conditions, and this phenomenon is termed adaptive mutagenesis. At a molecular level, adaptive mutagenesis is medi...
Vo Thi Thuong Lan,Pham Thi Thanh Loan,Pham Anh Thuy Duong et al.
Vo Thi Thuong Lan et al.
DNA ladder is commonly used to determine the size of DNA fragments by electrophoresis in routine molecular biology laboratories. In this study, we report a new procedure to prepare a DNA ladder that consists of 10 fragments from 100 to 1000...
Using chemical approaches to understand RNA structure and function in biology [0.03%]
运用化学方法阐释RNA的结构及其在生物学中的功能
Dmitry A Stetsenko,Arthur van Aerschot
Dmitry A Stetsenko
Chemical approaches for structure and function of RNA in postgenomic era [0.03%]
基因组学时代RNA的结构与功能的化学研究方法学进展
Tae Suk Ro-Choi,Yong Chun Choi
Tae Suk Ro-Choi
In the study of cellular RNA chemistry, a major thrust of research focused upon sequence determinations for decades. Structures of snRNAs (4.5S RNA I (Alu), U1, U2, U3, U4, U5, and U6) were determined at Baylor College of Medicine, Houston,...
Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer [0.03%]
癌症中成纤维细胞生长因子受体IgIII循环的可变剪接
Klaus Holzmann,Thomas Grunt,Christine Heinzle et al.
Klaus Holzmann et al.
Alternative splicing of the IgIII loop of fibroblast growth factor receptors (FGFRs) 1-3 produces b- and c-variants of the receptors with distinctly different biological impact based on their distinct ligand-binding spectrum. Tissue-specifi...