The activation of glial cells in the medulla visceral zone impairs synaptic plasticity and promotes inflammation and immune disorders in sepsis [0.03%]
败血症时脊髓脏器区室胶质细胞活化损害突触可塑性并促进炎症和免疫紊乱
Jianjian Wang,Lizhi Wang,Weiwei Jiang et al.
Jianjian Wang et al.
Objective: Sepsis elicits neuroinflammation in the medullary visceral zone (MVZ), which disrupts the cholinergic anti-inflammatory pathway (CAP). However, the underlying mechanisms and translational therapeutic potential ...
Diverse roles of connexins in the neuro-vasculature in homeostasis and disease [0.03%]
连接蛋白在神经血管稳态和疾病中的多种作用
Valentin Delobel,Nafiisha Genet,Karen K Hirschi
Valentin Delobel
Significant progress has advanced our understanding of brain physiology. The brain is now recognized as an integrated network rather than a compartmentalized organ, composed of diverse cell types including neurons, glial cells, and vascular...
Oxidative stress and molecular chaperones: a dynamic crosstalk in neurodegenerative disorders [0.03%]
氧化应激与分子伴侣：神经退行性疾病中的动态相互作用
Leila Noori,Yousef Mohamadi,Francesco Cappello et al.
Leila Noori et al.
Neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease, and Huntington's disease are discussed as representative examples of conditions in which oxidative stress and proteostasis imbalance contribute to progressi...
Neuroprotective effects of Ershiwuwei Shanhu pills on APP/PS1 mice through antioxidant enhancement, anti-apoptosis, and MAPK pathway regulation [0.03%]
益智颗粒通过抗氧化、抗凋亡及MAPK信号通路对APP/PS1小鼠的神经保护作用研究
Ning Li,Xiaoyuan Peng,Wei Xiong et al.
Ning Li et al.
Objectives: Alzheimer's disease (AD) involves cognitive impairment, neuronal degeneration, oxidative imbalance, and abnormal MAPK signaling. This study investigated the protective effects of Ershiwuwei Shanhu Pills (ESP) ...
Regulation of FTO on PDCD5 mRNA stability to mediate neuron apoptosis in rats with hypoxic-ischemic brain damage [0.03%]
FTO通过调节PDCD5 mRNA稳定性介导缺血缺氧性脑损伤大鼠神经元凋亡的作用及机制研究
Taiyong Yin,Minshu Zou,Dali Liu et al.
Taiyong Yin et al.
Objectives: This study explored the mechanism of FTO in regulating neuron apoptosis in hypoxic-ischemic brain damage (HIBD) models via PDCD5. Methods: ...
Chunjiao Wang,Yanfen Chang,Hui Sheng
Chunjiao Wang
Depression is a debilitating mental disorder with a significantly higher prevalence in women, particularly during periods of hormonal fluctuation such as perimenopause, postpartum, and postmenopause. Estrogen, especially 17β-estradiol (E2)...
Rodents' episodic-like memory: concepts, ageing, neurodegeneration, future [0.03%]
啮齿动物的类情节记忆：概念、衰老、神经退行和未来方向
Andressa Gabriela Soliani,Beatriz Gangale Muratori,Jessica Santos Baptista et al.
Andressa Gabriela Soliani et al.
Episodic memory (EM), traditionally defined as the conscious recollection of what, where, and when events occurred, was long considered uniquely human due to its reliance on autonoetic awareness. However, behavioural criteria allow memory a...
Novel insight into PINK1/parkin-associated autophagy implicated in Parkinson disease [0.03%]
与帕金森病相关的PINK1/ parkin相关自噬的新见解
Judith Stegmüller
Judith Stegmüller
Parkinson disease (PD) and its variants pose a dramatic burden on patients, families and society. Deciphering the mechanistic underpinnings of PD are critical goals of researchers to develop new therapeutic approaches. Among the pathways af...
Thomas Parr,Giovanni Pezzulo,Karl J Friston
Thomas Parr
Episodic memories - declarative memories of past events, characterized by rich spatiotemporal context - play a central role in guiding perception and behaviour. Here, we advance a model that integrates episodic memories within the active in...
A retrospective study on the effects of unilateral biportal endoscopic lumbar interbody fusion on functional recovery in patients undergoing single-level lumbar interbody fusion [0.03%]
单节段腰椎间融合术患者接受单侧双孔内镜下腰椎椎间融合术后功能恢复的回顾性研究
Xinyun Huang,Shi Ling,Qi Cao
Xinyun Huang
Objectives: To compare the clinical outcomes of unilateral biportal endoscopic lumbar interbody fusion (ULIF) versus posterior lumbar interbody fusion (PLIF) in patients undergoing single-level L3-S1 lumbar interbody fusi...