Cannabinoid Therapies in Less-Common Disorders: Clinical Evidence and Formulation Strategies [0.03%]
Cannabinoids治疗少见疾病：临床证据及制剂策略
Silvia Afonso,Joana Gonçalves,Ana T Brinca et al.
Silvia Afonso et al.
Background/Objectives: Cannabinoids are increasingly recognised for their therapeutic potential beyond well-established indications such as chronic pain, multiple sclerosis, and specific epileptic syndromes. Recent advances have highlighted...
Nationwide Analysis of In-Hospital Mortality in Patients with Encephalitis-Related Diagnoses in Ecuador [0.03%]
厄瓜多尔脑炎患者住院死亡率的全国性分析
Karime Montes-Escobar,Christian Eduardo Ramirez-Veloz,Maribel Cecilia Pérez-Pirela et al.
Karime Montes-Escobar et al.
Background/objectives: Encephalitis and related acute encephalopathic syndromes represent severe neurological conditions with diverse etiologies and variable clinical outcomes. This study aimed to analyze nationwide hospi...
Long-Term Survival with Daratumumab, Lenalidomide and Dexamethasone in Transplant-Ineligible Newly Diagnosed Multiple Myeloma Patients-A Survey from Two Italian Centers [0.03%]
达雷妥尤单抗、来那度胺和地塞米松对适合移植的新诊断多发性骨髓瘤患者的长期生存影响：来自意大利两家中心的一项调查研究
Vittorio Del Fabro,Lara Gullo,Giuliana Giunta et al.
Vittorio Del Fabro et al.
Background: Multiple myeloma (MM) is a clonal plasma cell neoplasm representing the second most common hematological malignancy. The combination of daratumumab, lenalidomide and dexamethasone (D-Rd) was first approved by ...
Targeting Telomerase in Cancer: Vaccine-Based Strategies, Clinical Evidence, and Synergy with Immunotherapy [0.03%]
以疫苗为基础的策略针对癌症中的端粒酶：临床证据及其与免疫治疗之间的协同作用
Stella Baliou,Manolis N Tzatzarakis,Andreas G Tsantes et al.
Stella Baliou et al.
With each replication cycle, telomeres shorten. Telomerase can slow or reverse the rate of telomere shortening. In the era of cancer immunotherapy, telomerase is a promising tumor-associated antigen due to its widespread and specific expres...
Identification of Novel Trypanosoma cruzi Cysteine Protease Inhibitors via Ligand-Based Virtual Screening of FDA-Approved Drugs with Trypanocidal Activity [0.03%]
基于FDA批准的具有杀虐血病活性的药物进行虚拟筛选以识别新型克氏锥虫半胱氨酸蛋白酶抑制剂
Lenci K Vázquez-Jiménez,Alonzo González-González,Timoteo Delgado-Maldonado et al.
Lenci K Vázquez-Jiménez et al.
Background: Chagas disease is a major public health problem, especially in Latin American countries, and benznidazole and nifurtimox are currently the only drugs available for its treatment. However, they present several ...
Predictors of Long-Term Prognosis Focused on Kidney Function in Patients with Chronic Coronary Syndrome [0.03%]
慢性冠状动脉综合征患者长期预后(以肾功能为重点)的影响因素分析
Katarzyna Charkiewicz-Szeremeta,Emilia Sawicka-Śmiarowska,Marlena Dubatówka et al.
Katarzyna Charkiewicz-Szeremeta et al.
Background: The number of patients with chronic coronary syndromes (CCS) is growing, influenced by factors such as increasing life expectancy and prevalence of risk factors. Thus, cardiovascular (CV) disease remains the l...
Gut Microbiome Recovery in Clostridioides difficile Infection Patients Receiving Multi-Strain Probiotics During Convalescence: A Prospective Pilot Series of Longitudinal Dynamics [0.03%]
利福昔明联合复方多菌株益生菌治疗艰难梭菌感染患者的肠道菌群恢复：纵向动态观察性研究
Dorin Novacescu,Talida Georgiana Cut,Adelina Baloi et al.
Dorin Novacescu et al.
Background/Objectives:Clostridioides difficile infection (CDI) is a major healthcare-associated infection associated with profound antibiotic-induced gut microbiome disruption that frequently persists after clinical resolution. This pilot s...
Diagnosis and Management of Patients with Cardiac Sarcoidosis by a Regional Specialist Service [0.03%]
区域性专家服务中心的心脏肉芽肿病患者的诊断和管理
Rebecca Godfrey,Otto Fenske,Raj Selvaraju et al.
Rebecca Godfrey et al.
Background: Cardiac sarcoidosis (CS) is associated with potentially serious complications, including heart failure and life-threatening arrhythmias. The diagnosis and management of CS is multifaceted, requiring a multi-di...
Factors Associated with GLP-1 Receptor Agonist Use in Patients with Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease: A Retrospective Propensity-Score Matched Analysis [0.03%]
二型糖尿病合并动脉粥样硬化性心血管疾病的患者使用GLP-1受体激动剂的影响因素分析：倾向匹配的回顾性研究
Georgios Vournas,Leonidas Mourgos,Michael Doumas et al.
Georgios Vournas et al.
Background: Atherosclerotic cardiovascular disease (ASCVD) frequently coexists with type 2 diabetes (T2D), amplifying morbidity and mortality. Glucagon-like peptide-1 receptor agonists (GLP-1RA) confer significant cardiovascular benefits an...
Awareness and Perceived Risk Factors of Chronic Kidney Disease Among Patients with Diabetes in the Northern Borders of Saudi Arabia: Implications for a Strategic Monitoring and Management Plan [0.03%]
沙特阿拉伯北部糖尿病患者慢性肾脏疾病的认识及风险因素知觉：战略性监测和管理计划的启示
Safya E Esmaeel,Altaf Saleh Mahdi Alanazi Alnzi,Nouf Mofareh Mulahed Alanazi et al.
Safya E Esmaeel et al.
Background/Objectives: Chronic kidney disease (CKD) poses a significant health burden for individuals with diabetes mellitus, increasing morbidity and mortality. Understanding CKD and its risk factors is essential for early detection, effec...