Epigenetic Landscape of the Citrus Greek National Germplasm Collection and Its Association with Genetic and Fitness-Related Data [0.03%]
希腊柑橘国家种质资源保存库的表观遗传景观及其与基因型和适应性状的关系
Fani G Lyrou,Vasiliki Maria Kotina,Andreas G Doulis et al.
Fani G Lyrou et al.
Epigenetic diversity contributes to phenotypic plasticity and environmental responsiveness in Citrus spp. In this work, genome-wide DNA methylation was analyzed in 49 accessions representing six Citrus species, hybrids, varieties, and culti...
In Silico-Identified Peptides of Five Borrelia burgdorferi Proteins Binding with High Affinity to Human Leukocyte Antigen (HLA) Class II Alleles [0.03%]
五种伯氏疏螺旋体蛋白质的丝裂霉素C抗性蛋白MsrA家族蛋白等与人类白细胞抗原结合的亲和力高的肽段的计算机筛选识别
Apostolos P Georgopoulos,Lisa M James,Matthew Sanders
Apostolos P Georgopoulos
To date, Lyme vaccine development has largely overlooked the vaccinee's human leukocyte antigen (HLA) genetic makeup on which antibody production critically depends. Here, we evaluated in silico the predicted binding affinities of 192 HLA-I...
Identification of a Novel Disulfidptosis-Related Five-Gene Signature for Prognostic Prediction and Immune Characterization in Esophageal Cancer [0.03%]
一种新型的与二硫化物诱导细胞死亡相关的五基因标志物在预测食管癌预后和免疫表型中的识别作用
Yiru Chen,Xuefeng Li,Hui Jiang et al.
Yiru Chen et al.
Esophageal cancer is a highly aggressive malignancy with a poor prognosis. More precise prognostic biomarkers are therefore needed. Disulfidptosis is a recently identified form of regulated cell death driven by disulfide stress. It has been...
Characterization of the Complete Mitochondrial Genome of Nibea chui: Resolving a Taxonomic Controversy and New Phylogenetic Insights into Sciaenidae [0.03%]
Nibea chui完整线粒体基因组的特征分析：解决分类争议并揭示Sciaenidae科鱼类的新进化关系
Chuanhao Chen,Ang Li,Shufang Liu
Chuanhao Chen
N. chui is an economically important marine fish species distributed along the coastal waters of China, renowned for its delicate flesh texture and high-quality dried swim bladder. However, its scientific name and taxonomic relationship wit...
Evidence for the Link Between KK-42 and the DH-PBAN Gene in Two Silkmoth Species, with Impacts on Developmental Traits [0.03%]
家蚕KK-42与DH-PBAN基因连锁关系的证据及对发育性状的影响分析
Haixu Bian,Yufeng Lin,Yuping Li et al.
Haixu Bian et al.
Diapause hormone (DH) is an important endocrine substance capable of influencing diapause in Lepidoptera moths that is encoded by the neuropeptide hormone DH-PBAN gene. Imidazole derivative KK-42 is a synthetic insect growth regulator that ...
Decoding the Clinical and Therapeutic Significance of MEAK7 in Triple-Negative Breast Cancer Through Integrative Bioinformatics [0.03%]
通过综合生物信息学解码三阴性乳腺癌中MEAK7的临床和治疗意义
Durmus Ayan,Meltem Uyaner Kan,Ergul Bayram et al.
Durmus Ayan et al.
Triple-negative breast cancer (TNBC) represents a clinically challenging breast cancer (BC) subtype, characterized by aggressive behavior, high recurrence risk, and limited therapeutic options. MEAK7 has been identified as an alternative mT...
When Infection Meets Inflammation: Listeria monocytogenes and Host Signaling Pathways [0.03%]
感染碰上炎症：单核细胞增多性李斯特菌与宿主信号途径
Yanyan Jia,Ke Yang,Rongxian Guo et al.
Yanyan Jia et al.
Listeria monocytogenes (L. monocytogenes) is a significant zoonotic pathogen responsible for listeriosis, a foodborne infection with high mortality. The inflammasome, an innate immune complex, plays a critical role in controlling pathogenic...
Enzymatic Degradation of Polyethylene Terephthalate Model Substrates by Esterase E4 [0.03%]
E4酯酶降解聚对苯二甲酸乙二醇酯模型底物的研究
Shuyan Duan,Huifang Yang,Rumeng Sun et al.
Shuyan Duan et al.
As the demand for polyethylene terephthalate (PET) continues to rise, significant environmental pollution caused by challenges in PET degradation has garnered global attention. Given the crucial role of esterases in depolymerizing PET into ...
FGF23 Controls Myocardial Fibrosis Progression via Promoting Cardiac Fibroblast Proliferation and Activation in Mice [0.03%]
FGF23通过促进心脏纤维细胞增殖和活化控制小鼠心肌纤维化的发展进展
Leyi Shen,Mingqi Hu,Mei Xue et al.
Leyi Shen et al.
Heart failure (HF) is the leading cause of morbidity and mortality worldwide, while myocardial fibrosis acts as a pivotal hallmark, which exacerbates ventricular dysfunction and remodeling in HF. In this study, we found FGF23, a critical en...
Asparagus Decline and Replant Problem: Autotoxicity, Autotoxic Substances, and Their Biological Functions [0.03%]
芦笋自毒作用、自毒物质及其生物学功能
Hisashi Kato-Noguchi,Midori Kato
Hisashi Kato-Noguchi
The cultivation of asparagus (Asparagus officinalis L.) is plagued by two serious issues: "asparagus decline" and "asparagus replant problem". The average lifespan of an asparagus plant is 15 to 20 years. However, its productivity decreases...