Antibiotic Use in the Community in Spain: A National Surveillance System Within the Framework of the Spanish Action Plan on Antimicrobial Resistance [0.03%]
西班牙社区抗生素使用情况：在西班牙抗菌素耐药行动计划框架内的国家监测系统
Rocío Fernández-Urrusuno,Carmen Marina Meseguer-Barros,María García-Gil et al.
Rocío Fernández-Urrusuno et al.
Background: Antimicrobial resistance (AMR) remains a critical major public health challenge, largely driven by the inappropriate use of antibiotics in the community. In Spain, the National Action Plan on AMR (PRAN) emphasizes the need for r...
Existing Evidence from Economic Evaluations of Antimicrobial Resistance-A Systematic Literature Review [0.03%]
抗菌药物耐药性的经济学评价的现有证据——系统综述文献
Sajan Gunarathna,Yongha Hwang,Jung-Seok Lee
Sajan Gunarathna
Background/Objectives: Although antimicrobial resistance (AMR) is recognized as a critical global health threat across human, animal, and environmental domains, evidence from AMR economic evaluations remains limited. This study systematical...
An Analysis of Primary Healthcare Antibiotic Prescription Rates Within Castile and Leon (Spain): 2013-2023 [0.03%]
2013至2023年卡斯蒂利亚-莱昂初级医疗抗生素处方率分析
Rocío Salvador Martín,María José Sierra-Medina,María Elena Sánchez-Gutiérrez et al.
Rocío Salvador Martín et al.
Background/Objectives: According to the World Health Organization, more than one million deaths each year are attributable to bacterial resistance, making it one of today's main public health threats that could cause up to 10 million deaths...
From Tears to Toxins: Mapping Antibiotic Passage Through the Eye-Liver Axis [0.03%]
从眼泪到毒素：抗生素通过眼-肝轴转运的图谱测绘研究
Ivan Šoša
Ivan Šoša
Traditionally used to combat infections, systemic effects of antibiotics are increasingly recognized in the context of absorption through unconventional routes. One such as the ocular surface. This review tackles the bidirectional liver-eye...
Changing Antibiotic Prescribing Cultures: A Comprehensive Review of Social Factors in Outpatient Antimicrobial Stewardship and Lessons Learned from the Local Initiative AnTiB [0.03%]
抗生素处方文化的改变：门诊抗菌药物管理中的社会因素综合分析及本地抗菌药物管理倡议的启示
Janina Soler Wenglein,Reinhard Bornemann,Johannes Hartmann et al.
Janina Soler Wenglein et al.
Antimicrobial resistance (AMR) constitutes a major global health challenge, driven significantly by inappropriate antibiotic use in human medicine. Despite the existence of evidence-based guidelines, variability in antibiotic prescribing pe...
Trends in Antimicrobial Resistance at a Greek Tertiary Hospital over a 7-Year Period, Including the COVID-19 Pandemic [0.03%]
希腊一家三级医院七年来的抗菌药物耐药趋势，包括COVID-19大流行期间的影响
Eleni Mylona,Sofia Kostourou,Dimitroula Giankoula et al.
Eleni Mylona et al.
Background/Objectives: Antimicrobial resistance (AMR) remains a major global threat, with the COVID-19 pandemic influencing its dynamics, although its overall impact remains uncertain. This study analyzed seven-year AMR trends, including th...
Regulation of the Expression of nucS, a Key Component of the Mismatch Repair System in Mycobacteria [0.03%]
调控结核分支杆菌错配修复系统关键组分nucS基因的表达
Esmeralda Cebrián-Sastre,Ángel Ruiz-Enamorado,Alfredo Castañeda-García et al.
Esmeralda Cebrián-Sastre et al.
Mismatch repair (MMR) system alterations can trigger transient hypermutation, promoting adaptive mutations under stress, such as antibiotic exposure. While most organisms use MutS and MutL protein families for MMR, many archaea and actinoba...
Antibiotic Resistance Patterns of Bacteria Involved in Colonization and/or Infection of Patients in Intensive Care Units in Northeastern Romania [0.03%]
东北罗马尼亚重症监护病房患者定植和/或感染细菌的抗生素耐药模式
Alexandru Duhaniuc,Cristina Mihaela Sima,Georgiana Buruiană et al.
Alexandru Duhaniuc et al.
Background/objectives: Healthcare-associated infections caused by multidrug-resistant (MDR) bacteria pose a significant and growing public health challenge, particularly in high-risk settings such as Intensive Care Units ...
Probiotics and Antibiotics Use for the Prevention of Travelers' Diarrhea Among Polish Tourists-Results from an Online Survey: Why Is Education Needed? [0.03%]
波兰游客用于预防旅游者腹泻的益生菌和抗生素的使用情况——在线调查结果：为什么需要开展教育？
Martyna Biała,Michał Biały,Patrycja Leśnik
Martyna Biała
Background/Objectives: Traveler's diarrhea (TD) is a pressing issue, affecting a significant portion of international travelers. Despite the guidelines discouraging routine use of antibiotics and the inconclusive evidence supporting probiot...
Assessment of Polymyxin B with Sodium Deoxycholate Sulfate Micelles in a Rat Model to Combat Polymyxin Nephrotoxicity [0.03%]
聚多粘菌素B-脱氧胆酸钠硫酸盐胶束在大鼠模型中对抗聚多粘菌素肾毒性的评估研究
Muhammad Ali Khumaini Mudhar Bintang,Jongdee Nopparat,Teerapol Srichana
Muhammad Ali Khumaini Mudhar Bintang
Background/Objectives: Polymyxin B (PMB) was incorporated into a sodium deoxycholate sulfate (SDCS) micelle formulation to mitigate polymyxin-induced nephrotoxicity. This study examined the effect of the formulation on nephrotoxicity and bi...