Distribution of Fimbrial Genes and Their Association with Virulence and Levofloxacin Resistance/Extended-Spectrum Beta-Lactamase Production in Uropathogenic Escherichia coli [0.03%]
菌毛基因的分布及其与尿源性致病大肠杆菌毒力及左氧氟沙星耐药/超广谱β内酰胺酶产生的相关性分析
Masao Mitsui,Takanori Sekito,Mai Maruhashi et al.
Masao Mitsui et al.
Background: Urinary tract infection (UTI) is predominantly caused by uropathogenic Escherichia coli (UPEC). Previous studies have reported that the fimbriae of UPEC are involved in virulence and antimicrobial resistance. We aimed to analyze...
Antibiotic De-Escalation in the Intensive Care Unit: Rationale and Potential Strategies [0.03%]
重症监护室抗生素降级治疗的原理和潜在策略
Sarah Singer Matuszak,Lauren Kolodziej,Scott Micek et al.
Sarah Singer Matuszak et al.
Antibiotic de-escalation (ADE) is important to help optimize antibiotic use and balance the positive and negative effects of antimicrobial therapy. ADE should be performed promptly, and infections should be treated with the shortest course ...
Stability of Nine Time-Dependent Antibiotics for Outpatient Parenteral Antimicrobial Therapy (OPAT) Use [0.03%]
九种时间依赖性抗生素在外出行动抗菌治疗中的稳定性研究
Elise d&#x;Huart,Ibtissem Boutouha,Clara Berardi et al.
Elise d&#x;Huart et al.
Background: The use of an elastomeric diffuser is favored to administer outpatient antibiotic therapy. A study published in 2022 highlighted the instability of several antibiotics in elastomeric devices at 37 °C. The objective was to evalu...
Mutation- and Transcription-Driven Omic Burden of Daptomycin/Dalbavancin-R and Glycopeptide-RS Fitness Costs in High-Risk MRSA: A Nexus in Antimicrobial Resistance Mechanisms-Genome Proneness-Compensatory Adaptations [0.03%]
达普森/达尔巴万cin-r和糖肽rs适应性成本的高危mrsa突变转录组负担：抗菌药物耐药机制-基因组易感性-补偿性适应的交汇点
Eleonora Chines,Gaia Vertillo Aluisio,Maria Lina Mezzatesta et al.
Eleonora Chines et al.
Background: In Staphylococcus aureus, antimicrobial resistance (AMR) imposes significant fitness costs (FCs), including reduced growth rate, interbacterial competitiveness, and virulence. However, the FC molecular basis r...
Outcome of Bloodstream Infections Caused by Antibiotic-Resistant Bacteria: A 7-Year Retrospective Study at the University Hospital of Palermo, Italy [0.03%]
意大利巴勒莫大学医院抗生素耐药菌所致血流感染结局：7年回顾性研究
Luca Pipitò,Eleonora Bono,Chiara Vincenza Mazzola et al.
Luca Pipitò et al.
Background: Bloodstream infections (BSIs) are both a primary cause and a severe complication of hospitalization. This retrospective study aims to analyze the epidemiology of BSIs at the University Hospital of Palermo from...
Impact of Timing of Beta-Lactam Therapeutic Drug Monitoring and Therapy Adjustment in Critically Ill Patients [0.03%]
不同时间进行β内酰胺类药物治疗药物监测及其指导下的调整剂量对重症患者的影响
Mohammad H Alshaer,Nicole F Maranchick,Kelly L Maguigan et al.
Mohammad H Alshaer et al.
Purpose: To assess the impact of beta-lactam therapeutic drug monitoring (TDM) timing and therapy adjustment on clinical cure and 30-day mortality. Methods: This was a prospective study of critically ill patients admitted to the University ...
First Report of CTX-M-32 and CTX-M-101 in Proteus mirabilis from Zagreb, Croatia [0.03%]
克罗地亚萨格勒布的阴沟肠杆菌中首次发现CTX-M-32和CTX-M-101
Branka Bedenić,Josefa Luxner,Gernot Zarfel et al.
Branka Bedenić et al.
Background/objectives: Proteus mirabilis is a frequent causative agent of urinary tract and wound infections in community and hospital settings. It develops resistance to expanded-spectrum cephalosporins (ESC) due to the ...
Chronic Heat Stress Can Induce Conjugation of a Novel ermB-Containing ICEFZMF, Increasing Resistance to Erythromycin Among Enterococcus Strains in Diverse Intestinal Segments in the Mouse Model [0.03%]
慢性热应激可以诱导小鼠模型中携带新型ermBICEFZMF的肠球菌株在不同肠道节段中共轭，从而增加其对红霉素的耐药性
Lingxian Yi,Zining Ren,Yu Feng et al.
Lingxian Yi et al.
Background: The impact of heat stress on intestinal bacterial antimicrobial resistance (AMR) and its underlying mechanisms is not fully understood. This study aims to explore how heat stress influences AMR in the gut and ...
New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin Biocomposites [0.03%]
对抗多重耐药细菌的新视角：内溶酶生物复合材料的潜力
Carlos E Camacho-González,Cesar S Cardona-Felix,Alejandro Pérez-Larios et al.
Carlos E Camacho-González et al.
The growing threat of multidrug-resistant bacteria requires innovative therapies beyond traditional antibiotics. This review highlights the potential of endolysin biocomposites using alginate oligosaccharides (AOSs) and modified cellulose (...
Antimicrobial Lock Therapy: A Strategy for Managing Catheter-Related Bacteremia [0.03%]
抗菌锁治疗：导管相关性菌血症的治疗方法
Firdevs Aksoy,Hanife Nur Karakoc Parlayan,Gulter Oncu Kurutas et al.
Firdevs Aksoy et al.
Objectives: This study aims to evaluate the use and efficacy of antibiotic-lock therapy (ALT) in the management of catheter-related bloodstream infections (CRBSIs), focusing on its impact on infection resolution, catheter...